Paxip1 | ENSMUSG00000002221 | NCBI 55982

Details for: Paxip1

Gene ID: 55982

Symbol: Paxip1

Ensembl ID: ENSMUSG00000002221

Description: PAX interacting (with transcription-activation domain) protein 1

Associated with

Dna double-strand break repair
(R-MMU-5693532)
Epigenetic regulation of gene expression
(R-MMU-212165)
Formation of wdr5-containing histone-modifying complexes
(R-MMU-9772755)
Gene expression (transcription)
(R-MMU-74160)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Adipose tissue development
(GO:0060612)
Chorion development
(GO:0060717)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Endothelial cell migration
(GO:0043542)
Histone methyltransferase complex
(GO:0035097)
Mll3/4 complex
(GO:0044666)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of isotype switching
(GO:0045830)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein binding
(GO:0005515)
Regulation of cell cycle g2/m phase transition
(GO:1902749)
Response to ionizing radiation
(GO:0010212)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

PAX-interacting protein 1

Genular Protein ID: 2535821703

Symbol: PAXI1_MOUSE

Name: PAX-interacting protein 1

UniProtKB Accession Codes:

Q6NZQ4 Q9Z0W6

Database IDs:

Citations:

PubMed ID: 10908331

Title: PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.

PubMed ID: 10908331

DOI: 10.1093/nar/28.14.2741

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12588986

Title: BRCT domain-containing protein PTIP is essential for progression through mitosis.

PubMed ID: 12588986

DOI: 10.1128/mcb.23.5.1666-1673.2003

PubMed ID: 17925232

Title: The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

PubMed ID: 17925232

DOI: 10.1016/j.devcel.2007.09.004

PubMed ID: 19124460

Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

PubMed ID: 19124460

DOI: 10.1074/jbc.m809158200

PubMed ID: 19414588

Title: PTIP regulates 53BP1 and SMC1 at the DNA damage sites.

PubMed ID: 19414588

DOI: 10.1074/jbc.m109.002527

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20671152

Title: PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.

PubMed ID: 20671152

DOI: 10.1126/science.1187942

PubMed ID: 26744420

Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

PubMed ID: 26744420

DOI: 10.1101/gad.268797.115

Sequence Information:

Length: 1056
Mass: 119269
Checksum: 86762841515A07AB
Sequence:

MSEPAPEVPE ELFREVKYYA VGDIDPQVIQ LLKAGKAKEV SYNALASHII SEDGDNPEVG 
EAREVFDLPV VKPSWVTLSV QCGALLPVNG FSPESCQIFF GLTACLSQVS SEDRSALWAL 
VTFHGGSCQL NLNKKCTHLI VPEPKGEKYE RAVKRTSIKI VTPDWVLDCV SEKRRKDEAF 
YHPRLIIYEE EEEEEEEGDN EEQDSQNEGS TEKSSVASSA VASPAEQPCS PKPRAEVSKG 
ELMFDDSSDS SPEKQERSLN WAPAEAPPLN TAQRRLPQGK GPGLINLCAN VPPVPGDILP 
PDMRGNLMAP GQNLQNSERS EILGTWSPAV RTLRNITNNA DIQQINRPSN VAHILQSLSA 
PTKSLEQQVA RGQQGHPNAS AVLFGQAKGA PETHVLQQHH PPQQPQQQHP ALHLQPQIMQ 
LQQQQQQQQQ QQQQPQPYPQ PPSHQFPQQV HQHQFSQQQL QFPQQPLHPQ QQLHRPQQQL 
QPFQQQHALQ QQLHQLQQQQ LQHHQLAQLQ QQQQQQHNLL QQQQQQQQLQ RLQQQQQMQN 
QAAHLSQASQ ALQHQVLPQQ PLQLSLQPPP QQQQQQQLFG HDPAVEIPEE SFLLGCVFAI 
ADYPEQMSDK QLLATWKRII QAHGGTVDPT FTSRCTHLLC ASQVSSMYTQ ALRERKRCVT 
AHWLNTVLKK KKLMPPHRAL HFPVAFPPGG KPCSQHIISV TGFVDNDRDD LKLMAYLAGA 
KYTGYLCRSN TVLICKEPSG LKYEKAKEWR IPCVNAQWLG DILLGNFEAL RQVQYSRYTA 
FNMPDPFVPT PHLVLGLLDA WRTPVKVTAE LLMGVRLPPK LKPNEVANIQ PSSKRARIED 
LPPPTKKLTP ELTPLVLFTG FEPVQVQQYI KKLYILGGEV AECTKKCTHL IASKVTRTVK 
FLTAISVVKH IVTPDWLEEC FKRQTFIDEQ NYILRDAEAE VLFSFSLEES LKRAHVSPLF 
KTKYFYITPG ICPSLATMKA IVECAGGKVL AKQPSFRKLM EHKQNKSLSE IILISCENDL 
HLCREYFARG IDVHNAEFVL TGVLTQTLDY ESYKFN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Paxip1

Associated with

Other Information

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. PubMed ID: 10908331

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BRCT domain-containing protein PTIP is essential for progression through mitosis. PubMed ID: 12588986

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. PubMed ID: 17925232

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. PubMed ID: 19124460

PTIP regulates 53BP1 and SMC1 at the DNA damage sites. PubMed ID: 19414588

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. PubMed ID: 20671152

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. PubMed ID: 26744420