Details for: ACRV1

Gene ID: 56

Symbol: ACRV1

Ensembl ID: ENSG00000134940

Description: acrosomal vesicle protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.2
    Marker Score: 2328
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3180
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.27
    Marker Score: 1287
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7531
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 386.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.54
    Marker Score: 600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 974
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 277
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 835
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 185
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 315
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 336
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4128
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 431
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 206
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 248
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7618
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 980
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 434
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.1
    Marker Score: 975
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1
    Marker Score: 3832
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 913
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.08
    Marker Score: 790
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.08
    Marker Score: 629
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.07
    Marker Score: 1019
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 258
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 273
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 131
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.05
    Marker Score: 1049
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1864
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 78.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 98
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.03
    Marker Score: 136
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 194
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 52
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 82.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9

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Other Information

**Key characteristics** * The ACRV1 gene is located on chromosome 17q21.1. * It is a large gene with a length of approximately 1.6 megabase pairs. * The protein encoded by ACRV1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the surface of cells. * The protein is a key regulator of spermatogenesis. **Pathways and functions** The ACRV1 protein is involved in multiple pathways that are essential for spermatogenesis, including: * **Formation of the acrosome:** The ACRV1 protein is a component of the acrosome, a structure that is responsible for the initial steps of sperm maturation. * **Migration of the acrosome:** The acrosome is responsible for guiding the sperm through the fallopian tube. * **Maturation of the sperm:** The ACRV1 protein is also involved in the maturation of the sperm, including the formation of the flagellum and the development of the polar body. The ACRV1 protein is a critical factor in male fertility, and mutations in the gene can lead to infertility. **Clinical significance** Mutations in the ACRV1 gene have been linked to a number of human diseases, including: * **Male infertility:** Mutations in the ACRV1 gene are the most common cause of male infertility. * **Semen abnormalities:** Mutations in the ACRV1 gene can also cause semen abnormalities, such as teratospermia (an abnormal sperm shape) and oligozoospermia (a low count of sperm). * **Testicular cancer:** Mutations in the ACRV1 gene have been linked to an increased risk of testicular cancer. The ACRV1 gene is a promising target for the treatment of male infertility and other diseases that are caused by mutations in this gene.

Genular Protein ID: 922074576

Symbol: ASPX_HUMAN

Name: Acrosomal protein SP-10

UniProtKB Accession Codes:

P26436 Q53FF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 RefSeq 4 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1693291

Title: Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10.

PubMed ID: 1693291

DOI: 10.1095/biolreprod42.4.693

PubMed ID: 8373955

Title: Cloning and characterization of the gene coding for the human acrosomal protein SP-10.

PubMed ID: 8373955

DOI: 10.1095/biolreprod49.2.316

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7619499

Title: Characterization of alternatively spliced human SP-10 mRNAs.

PubMed ID: 7619499

DOI: 10.1002/mrd.1080410115

PubMed ID: 1637938

Title: Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes.

PubMed ID: 1637938

DOI: 10.1095/biolreprod47.1.11

Sequence Information:

  • Length: 265
  • Mass: 28156
  • Checksum: 318216453F20D68A
  • Sequence:
    • MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 
GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 
GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS 
STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP 
SMNLFSHGTR MQIICCRNQS FCNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.