Details for: ACRV1

Gene ID: 56

Symbol: ACRV1

Ensembl ID: ENSG00000134940

Description: acrosomal vesicle protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.2
    Marker Score: 2,328
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,180
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.27
    Marker Score: 1,287
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7,531
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 387
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.54
    Marker Score: 600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 974
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 277
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 835
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 185
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 315
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 336
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4,128
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 431
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 206
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 248
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7,618
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 980
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 434
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.1
    Marker Score: 975
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1
    Marker Score: 3,832
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 913
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.08
    Marker Score: 790
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.08
    Marker Score: 629
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.07
    Marker Score: 1,019
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 258
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 273
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 131
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.05
    Marker Score: 1,049
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1,864
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 98
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.03
    Marker Score: 136
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 194
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 52
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 83
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ACRV1 is widely expressed in various cell types, including erythrocytes, blood vessel endothelial cells, megakaryocytes, goblet cells, and stem cells from different tissues such as the cerebral cortex, intestinal crypts, and megakaryocyte-erythroid progenitor cells. This broad expression pattern suggests a multifunctional role in maintaining tissue homeostasis. 2. **Protein Structure:** ACRV1 is a type II transmembrane protein, consisting of an extracellular N-terminal domain and an intracellular C-terminal domain. The protein's structure is crucial for its function, as it allows for interactions with other proteins and signaling molecules. 3. **Cellular Localizations:** ACRV1 is found in various cellular compartments, including the plasma membrane, endosomes, and Golgi apparatus. Its localization to these compartments suggests a dynamic role in cellular processes, including signaling, trafficking, and vesicle formation. **Pathways and Functions:** 1. **Acrosomal Vesicle Formation:** ACRV1 plays a critical role in the formation and maturation of acrosomes, which are essential for sperm cell fertilization. The protein's involvement in acrosomal vesicle formation highlights its importance in reproductive biology. 2. **Protein Binding and Signaling:** ACRV1 interacts with other proteins, such as the sperm protein SP-10 (ASPX_HUMAN), to regulate cellular signaling and trafficking. These interactions suggest a role in modulating cell-cell communication and tissue homeostasis. 3. **Endocytosis and Exocytosis:** ACRV1 is involved in the regulation of endocytosis and exocytosis, processes critical for cellular homeostasis and tissue development. The protein's role in these processes highlights its importance in maintaining tissue homeostasis. **Clinical Significance:** 1. **Reproductive Disorders:** Alterations in ACRV1 expression or function may contribute to reproductive disorders, such as infertility, aneuploidy, or impaired sperm function. 2. **Cancer and Tissue Homeostasis:** ACRV1's involvement in cellular processes, including protein binding, signaling, and endocytosis, suggests a potential role in cancer development and tissue homeostasis. Further studies are needed to elucidate the relationship between ACRV1 and cancer. 3. **Immune System and Inflammation:** ACRV1's expression in immune cells, such as endothelial cells and goblet cells, highlights its potential role in immune system function and inflammation. Further studies are needed to investigate the relationship between ACRV1 and immune responses. In conclusion, the Acrosomal Vesicle Protein 1 (ACRV1) is a multifunctional protein with significant implications in various cellular processes, including reproductive biology, tissue homeostasis, and immune function. Further research is needed to fully elucidate the role of ACRV1 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 922074576

Symbol: ASPX_HUMAN

Name: Acrosomal protein SP-10

UniProtKB Accession Codes:

P26436 Q53FF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 RefSeq 4 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1693291

Title: Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10.

PubMed ID: 1693291

DOI: 10.1095/biolreprod42.4.693

PubMed ID: 8373955

Title: Cloning and characterization of the gene coding for the human acrosomal protein SP-10.

PubMed ID: 8373955

DOI: 10.1095/biolreprod49.2.316

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7619499

Title: Characterization of alternatively spliced human SP-10 mRNAs.

PubMed ID: 7619499

DOI: 10.1002/mrd.1080410115

PubMed ID: 1637938

Title: Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes.

PubMed ID: 1637938

DOI: 10.1095/biolreprod47.1.11

Sequence Information:

  • Length: 265
  • Mass: 28156
  • Checksum: 318216453F20D68A
  • Sequence:
    • MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 
GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 
GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS 
STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP 
SMNLFSHGTR MQIICCRNQS FCNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.