Details for: ACRV1

Gene ID: 56

Symbol: ACRV1

Ensembl ID: ENSG00000134940

Description: acrosomal vesicle protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1311
    Cell Significance Index: 2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1119
    Cell Significance Index: 2.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0904
    Cell Significance Index: 5.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0821
    Cell Significance Index: 16.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0593
    Cell Significance Index: 17.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0577
    Cell Significance Index: 11.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0572
    Cell Significance Index: 2.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0529
    Cell Significance Index: 0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0448
    Cell Significance Index: 1.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0408
    Cell Significance Index: 1.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0244
    Cell Significance Index: 8.7400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.0165
    Cell Significance Index: 0.1200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0135
    Cell Significance Index: 0.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0096
    Cell Significance Index: 0.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0078
    Cell Significance Index: 0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0030
    Cell Significance Index: 0.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0027
    Cell Significance Index: -1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0030
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0085
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0119
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0148
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0154
    Cell Significance Index: -1.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0162
    Cell Significance Index: -1.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0163
    Cell Significance Index: -1.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0166
    Cell Significance Index: -1.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0166
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0182
    Cell Significance Index: -1.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0197
    Cell Significance Index: -0.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0210
    Cell Significance Index: -0.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0210
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0213
    Cell Significance Index: -0.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0222
    Cell Significance Index: -1.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0245
    Cell Significance Index: -0.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0251
    Cell Significance Index: -1.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0287
    Cell Significance Index: -0.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0295
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0308
    Cell Significance Index: -1.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0333
    Cell Significance Index: -0.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0353
    Cell Significance Index: -1.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0365
    Cell Significance Index: -0.8900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0384
    Cell Significance Index: -0.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0419
    Cell Significance Index: -1.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0426
    Cell Significance Index: -0.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0431
    Cell Significance Index: -1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0452
    Cell Significance Index: -1.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0475
    Cell Significance Index: -1.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0484
    Cell Significance Index: -1.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0506
    Cell Significance Index: -1.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0518
    Cell Significance Index: -1.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0524
    Cell Significance Index: -1.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0538
    Cell Significance Index: -1.8700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0556
    Cell Significance Index: -0.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0558
    Cell Significance Index: -2.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0559
    Cell Significance Index: -1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0562
    Cell Significance Index: -0.8100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0585
    Cell Significance Index: -0.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0596
    Cell Significance Index: -0.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0599
    Cell Significance Index: -1.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0599
    Cell Significance Index: -0.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0625
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0638
    Cell Significance Index: -1.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0647
    Cell Significance Index: -1.7300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0651
    Cell Significance Index: -0.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0697
    Cell Significance Index: -1.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0722
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0729
    Cell Significance Index: -2.0900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0738
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0739
    Cell Significance Index: -2.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0743
    Cell Significance Index: -1.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0746
    Cell Significance Index: -1.8200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0749
    Cell Significance Index: -0.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0753
    Cell Significance Index: -1.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0762
    Cell Significance Index: -0.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0763
    Cell Significance Index: -1.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0764
    Cell Significance Index: -1.9100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0769
    Cell Significance Index: -1.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0772
    Cell Significance Index: -1.6500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0779
    Cell Significance Index: -1.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0779
    Cell Significance Index: -1.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0781
    Cell Significance Index: -1.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0782
    Cell Significance Index: -1.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0787
    Cell Significance Index: -1.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0788
    Cell Significance Index: -1.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0814
    Cell Significance Index: -1.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0819
    Cell Significance Index: -1.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0831
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ACRV1 is widely expressed in various cell types, including erythrocytes, blood vessel endothelial cells, megakaryocytes, goblet cells, and stem cells from different tissues such as the cerebral cortex, intestinal crypts, and megakaryocyte-erythroid progenitor cells. This broad expression pattern suggests a multifunctional role in maintaining tissue homeostasis. 2. **Protein Structure:** ACRV1 is a type II transmembrane protein, consisting of an extracellular N-terminal domain and an intracellular C-terminal domain. The protein's structure is crucial for its function, as it allows for interactions with other proteins and signaling molecules. 3. **Cellular Localizations:** ACRV1 is found in various cellular compartments, including the plasma membrane, endosomes, and Golgi apparatus. Its localization to these compartments suggests a dynamic role in cellular processes, including signaling, trafficking, and vesicle formation. **Pathways and Functions:** 1. **Acrosomal Vesicle Formation:** ACRV1 plays a critical role in the formation and maturation of acrosomes, which are essential for sperm cell fertilization. The protein's involvement in acrosomal vesicle formation highlights its importance in reproductive biology. 2. **Protein Binding and Signaling:** ACRV1 interacts with other proteins, such as the sperm protein SP-10 (ASPX_HUMAN), to regulate cellular signaling and trafficking. These interactions suggest a role in modulating cell-cell communication and tissue homeostasis. 3. **Endocytosis and Exocytosis:** ACRV1 is involved in the regulation of endocytosis and exocytosis, processes critical for cellular homeostasis and tissue development. The protein's role in these processes highlights its importance in maintaining tissue homeostasis. **Clinical Significance:** 1. **Reproductive Disorders:** Alterations in ACRV1 expression or function may contribute to reproductive disorders, such as infertility, aneuploidy, or impaired sperm function. 2. **Cancer and Tissue Homeostasis:** ACRV1's involvement in cellular processes, including protein binding, signaling, and endocytosis, suggests a potential role in cancer development and tissue homeostasis. Further studies are needed to elucidate the relationship between ACRV1 and cancer. 3. **Immune System and Inflammation:** ACRV1's expression in immune cells, such as endothelial cells and goblet cells, highlights its potential role in immune system function and inflammation. Further studies are needed to investigate the relationship between ACRV1 and immune responses. In conclusion, the Acrosomal Vesicle Protein 1 (ACRV1) is a multifunctional protein with significant implications in various cellular processes, including reproductive biology, tissue homeostasis, and immune function. Further research is needed to fully elucidate the role of ACRV1 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 922074576

Symbol: ASPX_HUMAN

Name: Acrosomal protein SP-10

UniProtKB Accession Codes:

P26436 Q53FF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 RefSeq 4 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1693291

Title: Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10.

PubMed ID: 1693291

DOI: 10.1095/biolreprod42.4.693

PubMed ID: 8373955

Title: Cloning and characterization of the gene coding for the human acrosomal protein SP-10.

PubMed ID: 8373955

DOI: 10.1095/biolreprod49.2.316

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7619499

Title: Characterization of alternatively spliced human SP-10 mRNAs.

PubMed ID: 7619499

DOI: 10.1002/mrd.1080410115

PubMed ID: 1637938

Title: Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes.

PubMed ID: 1637938

DOI: 10.1095/biolreprod47.1.11

Sequence Information:

  • Length: 265
  • Mass: 28156
  • Checksum: 318216453F20D68A
  • Sequence:
    • MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 
GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 
GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS 
STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP 
SMNLFSHGTR MQIICCRNQS FCNKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.