PDGFC | ENSG00000145431 | NCBI 56034

Details for: PDGFC

Gene ID: 56034

Symbol: PDGFC

Ensembl ID: ENSG00000145431

Description: platelet derived growth factor C

Associated with

Signaling by pdgf
(R-HSA-186797)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Animal organ morphogenesis
(GO:0009887)
Bone development
(GO:0060348)
Cell surface
(GO:0009986)
Cellular response to amino acid stimulus
(GO:0071230)
Central nervous system development
(GO:0007417)
Cytosol
(GO:0005829)
Digestive tract development
(GO:0048565)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast proliferation
(GO:0048144)
Golgi membrane
(GO:0000139)
Growth factor activity
(GO:0008083)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of protein autophosphorylation
(GO:0031954)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)

Other Information

Proteins

Platelet-derived growth factor C

Genular Protein ID: 2904753875

Symbol: PDGFC_HUMAN

Name: Platelet-derived growth factor C

UniProtKB Accession Codes:

Q9NRA1 B4DU34 B9EGR8 Q4W5M9 Q9UL22

Database IDs:

Citations:

PubMed ID: 11004490

Title: Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.

PubMed ID: 11004490

DOI: 10.1016/s0167-4781(00)00066-x

PubMed ID: 10858496

Title: A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family.

PubMed ID: 10858496

DOI: 10.1016/s0014-5793(00)01640-9

PubMed ID: 10806482

Title: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

PubMed ID: 10806482

DOI: 10.1038/35010579

PubMed ID: 11297552

Title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.

PubMed ID: 11297552

DOI: 10.1074/jbc.m101056200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11342471

Title: Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes.

PubMed ID: 11342471

DOI: 10.1161/01.cir.103.18.2242

PubMed ID: 11313995

Title: PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.

PubMed ID: 11313995

DOI: 10.1038/sj.onc.1204133

PubMed ID: 12176024

Title: Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells.

PubMed ID: 12176024

DOI: 10.1016/s0006-291x(02)00917-8

PubMed ID: 11854040

Title: Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization.

PubMed ID: 11854040

DOI: 10.1016/s1357-2725(01)00124-8

PubMed ID: 12032822

Title: Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines.

PubMed ID: 12032822

DOI: 10.1038/sj.onc.1205486

PubMed ID: 12707385

Title: PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases.

PubMed ID: 12707385

DOI: 10.1097/01.asn.0000062964.75006.a8

PubMed ID: 12598536

Title: Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.

PubMed ID: 12598536

DOI: 10.1074/jbc.m301728200

PubMed ID: 15061151

Title: PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.

PubMed ID: 15061151

DOI: 10.1161/01.atv.0000120785.82268.8b

PubMed ID: 15372073

Title: Tissue plasminogen activator is a potent activator of PDGF-CC.

PubMed ID: 15372073

DOI: 10.1038/sj.emboj.7600397

PubMed ID: 15247255

Title: Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.

PubMed ID: 15247255

DOI: 10.1074/jbc.m406063200

PubMed ID: 16279938

Title: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family.

PubMed ID: 16279938

DOI: 10.1111/j.1742-4658.2005.04989.x

PubMed ID: 15911618

Title: Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.

PubMed ID: 15911618

DOI: 10.1074/jbc.m503388200

PubMed ID: 15389578

Title: Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts.

PubMed ID: 15389578

DOI: 10.1002/jcp.20154

PubMed ID: 15728360

Title: Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma.

PubMed ID: 15728360

DOI: 10.1073/pnas.0409722102

PubMed ID: 16439802

Title: Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation.

PubMed ID: 16439802

DOI: 10.1165/rcmb.2005-0309oc

PubMed ID: 16443219

Title: Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines.

PubMed ID: 16443219

DOI: 10.1016/j.yexcr.2005.11.035

PubMed ID: 18055825

Title: PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines.

PubMed ID: 18055825

DOI: 10.1167/iovs.07-0327

PubMed ID: 17482170

Title: Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata.

PubMed ID: 17482170

DOI: 10.1016/j.fertnstert.2007.02.031

PubMed ID: 18172073

Title: Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.

PubMed ID: 18172073

DOI: 10.1167/iovs.07-0776

Sequence Information:

Length: 345
Mass: 39029
Checksum: CDE9E51F40633E78
Sequence:

MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII TVSTNGSIHS 
PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGTIL 
GRWCGSGTVP GKQISKGNQI RIRFVSDEYF PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA 
LPLDLLNNAI TAFSTLEDLI RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL 
LTEEVRLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK 
VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDGFC

Associated with

Other Information

Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract. PubMed ID: 11004490

A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. PubMed ID: 10858496

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. PubMed ID: 10806482

Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. PubMed ID: 11297552

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes. PubMed ID: 11342471

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. PubMed ID: 11313995

Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells. PubMed ID: 12176024

Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization. PubMed ID: 11854040

Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. PubMed ID: 12032822

PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases. PubMed ID: 12707385

Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. PubMed ID: 12598536

PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle. PubMed ID: 15061151

Tissue plasminogen activator is a potent activator of PDGF-CC. PubMed ID: 15372073

Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1. PubMed ID: 15247255

Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family. PubMed ID: 16279938

Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator. PubMed ID: 15911618

Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts. PubMed ID: 15389578

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. PubMed ID: 15728360

Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation. PubMed ID: 16439802

Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. PubMed ID: 16443219

PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. PubMed ID: 18055825

Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata. PubMed ID: 17482170

Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. PubMed ID: 18172073