Tgm2 | ENSRNOG00000012956 | NCBI 56083

Details for: Tgm2

Gene ID: 56083

Symbol: Tgm2

Ensembl ID: ENSRNOG00000012956

Description: transglutaminase 2

Associated with

Apoptotic cell clearance
(GO:0043277)
Blood vessel remodeling
(GO:0001974)
Bone development
(GO:0060348)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Calcium ion binding
(GO:0005509)
Cellular response to cocaine
(GO:0071314)
Cellular response to dopamine
(GO:1903351)
Cellular response to serotonin
(GO:1904015)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dopamine secretion
(GO:0014046)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Gene expression
(GO:0010467)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtp binding
(GO:0005525)
Histone dopaminyltransferase activity
(GO:0120297)
Histone serotonyltransferase activity
(GO:0120295)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of endoplasmic reticulum calcium ion concentration
(GO:0032471)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Peptide cross-linking
(GO:0018149)
Peptide histaminyltransferase activity
(GO:0120299)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase binding
(GO:0043274)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of mitochondrial calcium ion concentration
(GO:0051561)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of small gtpase mediated signal transduction
(GO:0051057)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein-glutamine gamma-glutamyltransferase activity
(GO:0003810)
Protein-glutamine glutaminase activity
(GO:0050568)
Protein domain specific binding
(GO:0019904)
Protein homooligomerization
(GO:0051260)
Proteolysis
(GO:0006508)
Regulation of apoptotic cell clearance
(GO:2000425)
Regulation of apoptotic process
(GO:0042981)
Salivary gland cavitation
(GO:0060662)

Other Information

Proteins

TGM2_RAT

Genular Protein ID: 1043584718

Symbol: TGM2_RAT

Name: N/A

UniProtKB Accession Codes:

Q9WVJ6 Q6P6R6

Database IDs:

Citations:

PubMed ID: 11073883

Title: Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells.

PubMed ID: 11073883

DOI: 10.1161/01.res.87.10.881

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7911253

Title: Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function.

PubMed ID: 7911253

DOI: 10.1126/science.7911253

PubMed ID: 12054611

Title: Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1.

PubMed ID: 12054611

DOI: 10.1016/s0006-291x(02)00197-3

PubMed ID: 14970202

Title: Functional coupling of rat myometrial alpha 1-adrenergic receptors to Gh alpha/tissue transglutaminase 2 during pregnancy.

PubMed ID: 14970202

DOI: 10.1074/jbc.m314299200

PubMed ID: 16341586

Title: Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.

PubMed ID: 16341586

DOI: 10.1007/s11064-005-8796-x

PubMed ID: 17179049

Title: Mechanism of allosteric regulation of transglutaminase 2 by GTP.

PubMed ID: 17179049

DOI: 10.1073/pnas.0609283103

PubMed ID: 29622788

Title: S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes.

PubMed ID: 29622788

DOI: 10.1038/s12276-017-0021-x

Sequence Information:

Length: 686
Mass: 76935
Checksum: 4CD3D377FA86EC1A
Sequence:

MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY EASVDRLTFG 
AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL SLQLCTPANA PVGQYRLSLE 
TSTGYQGSSF MLGHFILLFN AWCPADDVYL DSEAERREYV LTQQGFIYQG SVKFIKSVPW 
NFGQFEDGIL DACLMLLDVN PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR 
WDNNYGDGIS PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG YEGWQAIDPT 
PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD VVDWIRQSDG SVLKSINNSL 
VVGQKISTKS VGRDDREDIT YTYKYPEGSP EEREVFTRAN HLNKLAEKEE TGVAMRIRVG 
DGMSLGNDFD VFAHIGNDTS ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS 
IPLRILYEKY SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR VDLFPTDIGL 
HKLVVNFQCD KLKSVKGYRN IIIGPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tgm2

Associated with

Other Information

Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. PubMed ID: 11073883

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function. PubMed ID: 7911253

Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. PubMed ID: 12054611

Functional coupling of rat myometrial alpha 1-adrenergic receptors to Gh alpha/tissue transglutaminase 2 during pregnancy. PubMed ID: 14970202

Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. PubMed ID: 16341586

Mechanism of allosteric regulation of transglutaminase 2 by GTP. PubMed ID: 17179049

S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes. PubMed ID: 29622788