Hgs | ENSRNOG00000036696 | NCBI 56084

Details for: Hgs

Gene ID: 56084

Symbol: Hgs

Ensembl ID: ENSRNOG00000036696

Description: hepatocyte growth factor-regulated tyrosine kinase substrate

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Deubiquitination
(R-RNO-5688426)
Egfr downregulation
(R-RNO-182971)
Endosomal sorting complex required for transport (escrt)
(R-RNO-917729)
Lysosome vesicle biogenesis
(R-RNO-432720)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Negative regulation of met activity
(R-RNO-6807004)
Post-translational protein modification
(R-RNO-597592)
Rhobtb3 atpase cycle
(R-RNO-9706019)
Rho gtpase cycle
(R-RNO-9012999)
Rhou gtpase cycle
(R-RNO-9013420)
Signaling by egfr
(R-RNO-177929)
Signaling by met
(R-RNO-6806834)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by rho gtpases
(R-RNO-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-RNO-9716542)
Signal transduction
(R-RNO-162582)
Trans-golgi network vesicle budding
(R-RNO-199992)
Ub-specific processing proteases
(R-RNO-5689880)
Vesicle-mediated transport
(R-RNO-5653656)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome to lysosome transport
(GO:0008333)
Escrt-0 complex
(GO:0033565)
Identical protein binding
(GO:0042802)
Lysosome
(GO:0005764)
Membrane invagination
(GO:0010324)
Metal ion binding
(GO:0046872)
Multivesicular body membrane
(GO:0032585)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Phosphatidylinositol binding
(GO:0035091)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization to membrane
(GO:0072657)
Protein targeting to lysosome
(GO:0006622)
Protein transport
(GO:0015031)
Receptor internalization
(GO:0031623)
Secretory granule
(GO:0030141)
Ubiquitin-dependent protein binding
(GO:0140036)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Hepatocyte growth factor-regulated tyrosine kinase substrate

Genular Protein ID: 1154468329

Symbol: HGS_RAT

Name: Hepatocyte growth factor-regulated tyrosine kinase substrate

UniProtKB Accession Codes:

Q9JJ50 P97847 Q5XIV8 Q76N76

Database IDs:

Citations:

PubMed ID: 9039916

Title: Hrs-2 is an ATPase implicated in calcium-regulated secretion.

PubMed ID: 9039916

DOI: 10.1038/385826a0

PubMed ID: 9798906

Title: Molecular cloning of a rat brain cDNA, with homology to a tyrosine kinase substrate, that induces galactosylceramide expression in COS-7 cells.

PubMed ID: 9798906

DOI: 10.1046/j.1471-4159.1998.71051827.x

PubMed ID: 10825299

Title: Hrs interacts with SNAP-25 and regulates Ca2+-dependent exocytosis.

PubMed ID: 10825299

DOI: 10.1242/jcs.113.12.2273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10809762

Title: Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15.

PubMed ID: 10809762

DOI: 10.1074/jbc.275.20.15271

PubMed ID: 11110793

Title: Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor.

PubMed ID: 11110793

DOI: 10.1074/jbc.m004129200

PubMed ID: 17062640

Title: GRIF1 binds Hrs and is a new regulator of endosomal trafficking.

PubMed ID: 17062640

DOI: 10.1242/jcs.03249

Sequence Information:

Length: 776
Mass: 86246
Checksum: FD61BEC121F37E67
Sequence:

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH 
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKAAST TELPPEYLTS 
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKSTYTAHP KSEPAPLASS 
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ 
PGEGHTAPNS MVEAPLPETD SQPITSCSGP FSEQYQNGES EESHEQFLKA LQNAVSTFVN 
RMKSNHMRGR SITNDSAVLS LFQSINSTHP QLLELLNRLD ERRLYYEGLQ DKLAQIRDAR 
GALSALREEH REKLRRAAEE AERQRQIQLA QKLEIMRQKK QEYLEVQRQL AIQRLQEQEK 
ERQMRLEQQK QTVQMRAQMP AFPLPYAQLQ AMPTAGGVLY QPSGPTSFPG TFSPAGSVEG 
SPMHGVYMSQ PAPATGPYPS MPGTTADPSM VSAYMYPAGA PGAQAAPQAQ AGPTTNPAYS 
SYQPTPTPGY QNVASQAPQS LPAISQPPQT SNIGYMGSQP MSMGYQPYNM QNLMTTLPGQ 
DASLPAQQPY ITGQQPMYQQ MAPSTGPPQQ QPPVAQPPPT QGPPAQGNET QLISFD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hgs

Associated with

Other Information

Hrs-2 is an ATPase implicated in calcium-regulated secretion. PubMed ID: 9039916

Molecular cloning of a rat brain cDNA, with homology to a tyrosine kinase substrate, that induces galactosylceramide expression in COS-7 cells. PubMed ID: 9798906

Hrs interacts with SNAP-25 and regulates Ca2+-dependent exocytosis. PubMed ID: 10825299

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15. PubMed ID: 10809762

Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. PubMed ID: 11110793

GRIF1 binds Hrs and is a new regulator of endosomal trafficking. PubMed ID: 17062640