Details for: Tdp2

Gene ID: 56196

Symbol: Tdp2

Ensembl ID: ENSMUSG00000035958

Description: tyrosyl-DNA phosphodiesterase 2

Associated with

Other Information

Genular Protein ID: 4121135960

Symbol: TYDP2_MOUSE

Name: Tyrosyl-DNA phosphodiesterase 2

UniProtKB Accession Codes:

Q9JJX7 A2RTH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 16 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22740648

Title: TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

PubMed ID: 22740648

DOI: 10.1093/nar/gks622

PubMed ID: 24658003

Title: TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

PubMed ID: 24658003

DOI: 10.1038/ng.2929

PubMed ID: 23104055

Title: Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

PubMed ID: 23104055

DOI: 10.1038/nsmb.2418

PubMed ID: 24808172

Title: Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2DNA and Top2RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

PubMed ID: 24808172

DOI: 10.1074/jbc.m114.565374

PubMed ID: 27099339

Title: Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

PubMed ID: 27099339

DOI: 10.1042/bcj20160180

PubMed ID: 27060144

Title: Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

PubMed ID: 27060144

DOI: 10.1093/nar/gkw228

Sequence Information:

  • Length: 370
  • Mass: 41034
  • Checksum: A773A8889DF5BE83
  • Sequence:
    • MASGSSSDAA EPAGPAGRAA SAPEAAQAEE DRVKRRRLQC LGFALVGGCD PTMVPSVLRE 
NDWQTQKALS AYFELPENDQ GWPRQPPTSF KSEAYVDLTN EDANDTTILE ASPSGTPLED 
SSTISFITWN IDGLDGCNLP ERARGVCSCL ALYSPDVVFL QEVIPPYCAY LKKRAASYTI 
ITGNEEGYFT AILLKKGRVK FKSQEIIPFP NTKMMRNLLC VNVSLGGNEF CLMTSHLEST 
REHSAERIRQ LKTVLGKMQE APDSTTVIFA GDTNLRDQEV IKCGGLPDNV FDAWEFLGKP 
KHCQYTWDTK ANNNLRIPAA YKHRFDRIFF RAEEGHLIPQ SLDLVGLEKL DCGRFPSDHW 
GLLCTLNVVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.