Details for: Heyl

Gene ID: 56198

Symbol: Heyl

Ensembl ID: ENSMUSG00000032744

Description: hairy/enhancer-of-split related with YRPW motif-like

Associated with

  • Af-1 domain binding
    (GO:0050683)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Atrioventricular valve morphogenesis
    (GO:0003181)
  • Cardiac epithelial to mesenchymal transition
    (GO:0060317)
  • Cardiac ventricle morphogenesis
    (GO:0003208)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Circulatory system development
    (GO:0072359)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Glomerulus development
    (GO:0032835)
  • Mesenchymal cell development
    (GO:0014031)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Peripheral nervous system development
    (GO:0007422)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein homodimerization activity
    (GO:0042803)
  • Proximal tubule development
    (GO:0072014)
  • Pulmonary valve morphogenesis
    (GO:0003184)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription regulator complex
    (GO:0005667)
  • Ventricular septum morphogenesis
    (GO:0060412)

Other Information

Genular Protein ID: 805098411

Symbol: HEYL_MOUSE

Name: Hairy/enhancer-of-split related with YRPW motif-like protein

UniProtKB Accession Codes:

Q9DBX7 Q9JJV6 Q9QXW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 8 Ensembl 1 GO 38 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10588864

Title: HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments.

PubMed ID: 10588864

DOI: 10.1006/dbio.1999.9454

PubMed ID: 10860664

Title: Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.

PubMed ID: 10860664

DOI: 10.1006/geno.2000.6200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11044625

Title: Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.

PubMed ID: 11044625

DOI: 10.1016/s0925-4773(00)00459-7

PubMed ID: 11160397

Title: The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.

PubMed ID: 11160397

DOI: 10.1523/jneurosci.21-04-01265.2001

PubMed ID: 16199874

Title: Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.

PubMed ID: 16199874

DOI: 10.1128/mcb.25.20.8960-8970.2005

PubMed ID: 17303760

Title: Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

PubMed ID: 17303760

DOI: 10.1161/01.res.0000260913.95642.3b

Sequence Information:

  • Length: 326
  • Mass: 34929
  • Checksum: E7F71F1A1F8E00A3
  • Sequence:
    • MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI IEKRRRDRIN 
SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA SGGTGFFDAR ALAVDFRSIG 
FRECLTEVIR YLGVLEGPSS HADPVRIRLL SHLKSYAAEM EPSPTTTSAL AFPVWPWSFL 
HSCPGLPSLN SQLAILGRVP GPVLPSISSP PYPISALRSA PVHRPAGTIP PTRRNLLPSR 
GVTSTQRAHL PERPAAPPPT ALDARAARSI VPIPPCSPTT APGAGKSDDN VSGSISSPCP 
SGPTGRPAGA VFYHSWVSEI TEIGAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.