Htra1 | ENSMUSG00000006205 | NCBI 56213

Details for: Htra1

Gene ID: 56213

Symbol: Htra1

Ensembl ID: ENSMUSG00000006205

Description: HtrA serine peptidase 1

Associated with

Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Chorionic trophoblast cell differentiation
(GO:0060718)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Growth factor binding
(GO:0019838)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Molecular function activator activity
(GO:0140677)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of defense response to virus
(GO:0050687)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Peptidase activity
(GO:0008233)
Placenta development
(GO:0001890)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Programmed cell death
(GO:0012501)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Serine protease HTRA1

Genular Protein ID: 3180152866

Symbol: HTRA1_MOUSE

Name: Serine protease HTRA1

UniProtKB Accession Codes:

Q9R118 Q8BN04 Q8BN05 Q91WS3 Q9QZK6

Database IDs:

Citations:

PubMed ID: 14973287

Title: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.

PubMed ID: 14973287

DOI: 10.1242/dev.00999

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15101818

Title: Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.

PubMed ID: 15101818

DOI: 10.1042/bj20040435

PubMed ID: 15993670

Title: Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.

PubMed ID: 15993670

DOI: 10.1016/j.bone.2005.03.015

PubMed ID: 18551132

Title: HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

PubMed ID: 18551132

DOI: 10.1038/cdd.2008.82

PubMed ID: 22049084

Title: High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6.

PubMed ID: 22049084

DOI: 10.1074/jbc.m111.275990

Sequence Information:

Length: 480
Mass: 51214
Checksum: 92BDDA85CF5B12B7
Sequence:

MQSLRTTLLS LLLLLLAAPS LALPSGTGRS APAATVCPEH CDPTRCAPPP TDCEGGRVRD 
ACGCCEVCGA LEGAACGLQE GPCGEGLQCV VPFGVPASAT VRRRAQAGLC VCASSEPVCG 
SDAKTYTNLC QLRAASRRSE KLRQPPVIVL QRGACGQGQE DPNSLRHKYN FIADVVEKIA 
PAVVHIELYR KLPFSKREVP VASGSGFIVS EDGLIVTNAH VVTNKNRVKV ELKNGATYEA 
KIKDVDEKAD IALIKIDHQG KLPVLLLGRS SELRPGEFVV AIGSPFSLQN TVTTGIVSTT 
QRGGKELGLR NSDMDYIQTD AIINYGNSGG PLVNLDGEVI GINTLKVTAG ISFAIPSDKI 
KKFLTESHDR QAKGKAVTKK KYIGIRMMSL TSSKAKELKD RHRDFPDVLS GAYIIEVIPD 
TPAEAGGLKE NDVIISINGQ SVVTANDVSD VIKKENTLNM VVRRGNEDIV ITVIPEEIDP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Htra1

Associated with

Other Information

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. PubMed ID: 14973287

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. PubMed ID: 15101818

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. PubMed ID: 15993670

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival. PubMed ID: 18551132

High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6. PubMed ID: 22049084