Pals1 | ENSMUSG00000021112 | NCBI 56217

Details for: Pals1

Gene ID: 56217

Symbol: Pals1

Ensembl ID: ENSMUSG00000021112

Description: protein associated with LIN7 1, MAGUK family member

Associated with

Adherens junction
(GO:0005912)
Anchoring junction
(GO:0070161)
Apical part of cell
(GO:0045177)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Cell projection
(GO:0042995)
Central nervous system neuron development
(GO:0021954)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Establishment or maintenance of polarity of embryonic epithelium
(GO:0016332)
Gene expression
(GO:0010467)
Generation of neurons
(GO:0048699)
Golgi apparatus
(GO:0005794)
Guanylate kinase activity
(GO:0004385)
Identical protein binding
(GO:0042802)
Lateral loop
(GO:0043219)
Membrane
(GO:0016020)
Morphogenesis of an epithelial sheet
(GO:0002011)
Myelin assembly
(GO:0032288)
Myelin sheath adaxonal region
(GO:0035749)
Nucleotide binding
(GO:0000166)
Peripheral nervous system myelin maintenance
(GO:0032287)
Plasma membrane
(GO:0005886)
Plasma membrane organization
(GO:0007009)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Protein localization to myelin sheath abaxonal region
(GO:0035750)
Protein localization to plasma membrane
(GO:0072659)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Schmidt-lanterman incisure
(GO:0043220)

Other Information

Proteins

MAGUK p55 subfamily member 5

Genular Protein ID: 3832743965

Symbol: PALS1_MOUSE

Name: MAGUK p55 subfamily member 5

UniProtKB Accession Codes:

Q9JLB2

Database IDs:

Citations:

PubMed ID: 10753959

Title: Molecular cloning and characterization of Pals, proteins associated with mLin-7.

PubMed ID: 10753959

DOI: 10.1074/jbc.275.15.11425

PubMed ID: 11927608

Title: The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.

PubMed ID: 11927608

DOI: 10.1083/jcb.200109010

PubMed ID: 12527193

Title: Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).

PubMed ID: 12527193

DOI: 10.1016/s0378111902010843

PubMed ID: 12545177

Title: Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.

PubMed ID: 12545177

DOI: 10.1038/ncb923

PubMed ID: 15140881

Title: Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.

PubMed ID: 15140881

DOI: 10.1074/jbc.m401930200

PubMed ID: 15316081

Title: Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.

PubMed ID: 15316081

DOI: 10.1242/jcs.01301

PubMed ID: 15234345

Title: The GABA transporter GAT1 and the MAGUK protein Pals1: interaction, uptake modulation, and coexpression in the brain.

PubMed ID: 15234345

DOI: 10.1016/j.mcn.2004.03.006

PubMed ID: 15677456

Title: PALS1 specifies the localization of Ezrin to the apical membrane of gastric parietal cells.

PubMed ID: 15677456

DOI: 10.1074/jbc.m411941200

PubMed ID: 15558731

Title: Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.

PubMed ID: 15558731

DOI: 10.1002/cne.20367

PubMed ID: 16519681

Title: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane.

PubMed ID: 16519681

DOI: 10.1111/j.1742-4658.2006.05140.x

PubMed ID: 17920587

Title: FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.

PubMed ID: 17920587

DOI: 10.1016/j.yexcr.2007.08.025

PubMed ID: 17182851

Title: PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.

PubMed ID: 17182851

DOI: 10.1091/mbc.e06-07-0651

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20237282

Title: Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.

PubMed ID: 20237282

DOI: 10.1523/jneurosci.5185-09.2010

PubMed ID: 20399730

Title: The apical complex couples cell fate and cell survival to cerebral cortical development.

PubMed ID: 20399730

DOI: 10.1016/j.neuron.2010.03.019

PubMed ID: 22398208

Title: Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.

PubMed ID: 22398208

DOI: 10.1093/hmg/dds091

PubMed ID: 23893895

Title: MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Mueller cells.

PubMed ID: 23893895

DOI: 10.1002/glia.22545

PubMed ID: 23001562

Title: Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

PubMed ID: 23001562

DOI: 10.1093/hmg/dds398

PubMed ID: 26404741

Title: CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium.

PubMed ID: 26404741

DOI: 10.1038/srep14504

PubMed ID: 26657772

Title: The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.

PubMed ID: 26657772

DOI: 10.1242/dev.124180

PubMed ID: 27466317

Title: VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.

PubMed ID: 27466317

DOI: 10.1091/mbc.e16-02-0127

PubMed ID: 15241471

Title: Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.

PubMed ID: 15241471

DOI: 10.1038/sj.emboj.7600294

Sequence Information:

Length: 675
Mass: 77229
Checksum: 66670F919F18063B
Sequence:

MTTSYMNGHV TEESDSGIKN LDLASPEEYP KHREMAVDCP GDLGTRMMPV RRSAQLERIR 
QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID NPIFDTEEGI VLESPHYAVN 
ILDVEDLFSS LKHIQHTLVD SQSQEDISLL LQLVQNRDFQ NAFKIHNAVT VHMSKASPPF 
PLIANVQDLV QEVQTVLKPV HQKEGQELTA LLNAPHIQAL LLAHDKVAEQ EMQLEPITDE 
RVYESIGHYG GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE 
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV KAHFDYDPSD 
DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN QPLAGLVPGK SFQQQREAMK 
QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY NANKNDDYDN EEILTYEEMS LYHQPANRKR 
PIILIGPQNC GQNELRQRLM NKEKDRFASA VPHTTRNRRD HEVAGRDYHF VSRQAFEADI 
AAGKFIEHGE FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP 
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK AYQELLRLIN 
KLDTEPQWVP STWLR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pals1

Associated with

Other Information

Molecular cloning and characterization of Pals, proteins associated with mLin-7. PubMed ID: 10753959

The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. PubMed ID: 11927608

Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). PubMed ID: 12527193

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. PubMed ID: 12545177

Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust. PubMed ID: 15140881

Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. PubMed ID: 15316081

The GABA transporter GAT1 and the MAGUK protein Pals1: interaction, uptake modulation, and coexpression in the brain. PubMed ID: 15234345

PALS1 specifies the localization of Ezrin to the apical membrane of gastric parietal cells. PubMed ID: 15677456

Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina. PubMed ID: 15558731

MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. PubMed ID: 16519681

FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. PubMed ID: 17920587

PALS1 regulates E-cadherin trafficking in mammalian epithelial cells. PubMed ID: 17182851

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. PubMed ID: 20237282

The apical complex couples cell fate and cell survival to cerebral cortical development. PubMed ID: 20399730

Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis. PubMed ID: 22398208

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Mueller cells. PubMed ID: 23893895

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. PubMed ID: 23001562

CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. PubMed ID: 26404741

The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. PubMed ID: 26657772

VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. PubMed ID: 27466317

Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. PubMed ID: 15241471