Details for: Espn

Gene ID: 56226

Symbol: Espn

Ensembl ID: ENSMUSG00000028943

Description: espin

Associated with

Other Information

Genular Protein ID: 3552793465

Symbol: ESPN_MOUSE

Name: Espin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10975527

Title: The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.

PubMed ID: 10975527

DOI: 10.1016/s0092-8674(00)00042-8

PubMed ID: 12598619

Title: Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.

PubMed ID: 12598619

DOI: 10.1523/jneurosci.23-04-01310.2003

PubMed ID: 15190118

Title: Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells.

PubMed ID: 15190118

DOI: 10.1523/jneurosci.1279-04.2004

PubMed ID: 10588661

Title: Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque.

PubMed ID: 10588661

DOI: 10.1091/mbc.10.12.4327

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 14657236

Title: Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.

PubMed ID: 14657236

DOI: 10.1083/jcb.200309093

PubMed ID: 16569662

Title: Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells.

PubMed ID: 16569662

DOI: 10.1242/jcs.02869

PubMed ID: 19287378

Title: Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments.

PubMed ID: 19287378

DOI: 10.1038/ncb1851

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21455486

Title: Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice.

PubMed ID: 21455486

DOI: 10.1371/journal.pgen.1002032

PubMed ID: 22264607

Title: Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions.

PubMed ID: 22264607

DOI: 10.1016/j.cub.2011.12.053

PubMed ID: 26754646

Title: Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

PubMed ID: 26754646

DOI: 10.1083/jcb.201509017

PubMed ID: 26926603

Title: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.

PubMed ID: 26926603

DOI: 10.1038/ncomms10833

PubMed ID: 26785147

Title: Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin.

PubMed ID: 26785147

DOI: 10.7554/elife.12856

Sequence Information:

  • Length: 871
  • Mass: 94497
  • Checksum: C7707D5C73678DA1
  • Sequence:
  • MALEQALQAA RRGDLDVLRS LHAAGLLGPS LRDSLDALPV HHAARSGKLH CLRYLVEEVA 
    LPAVSRARNG ATPAHDAAAT GYLSCLQWLL TQGGCRVQEK DNSGATVLHL AARFGHPDVV 
    KWLLYQGGAN SAITTDTGAL PIHYAAAKGD LPSLKLLVGH YPEGVNAQTN NGATPLYLAC 
    QEGHLEVTKY LVQECSADPH LRAQDGMTPL HAAAQMGHNP VLVWLVSFAD VSFSEQDHDG 
    ATAMHFAASR GHTKVLSWLL LHGAEISQDL WGGTPLHDAA ENGELECCQI LAVNGAGLDV 
    RDHDGYTAAD LAEFNGHTHC SRYLRTVQTL SLEHRVLSRD QSMDLEAKQL DSGMSSPNTT 
    MSVQPMTFDL GSPTSTFSNY DSCSSSHSSS KGQRSNRGIP GARAADLQSY MDMLNPEKSL 
    PRGKLGKPSP PPPPPPPPPS FPPPPPPTGT QPPPPPPGYP APNPPVGLHL NNIYMQTKNK 
    LRHVEVDSLK EPKVELNDQF AQPSSGDGHS GLHRQDSGLL RQDSELLHRQ ELLRHSTGLR 
    RQDSDRKQRS FSKQPSTGDY YRQLGRSPGE PLAARPGMAH SEEAALLPGN HVHNGCSADS 
    KASRELPPPP PPPPLPEALS SPPPAPPLPI EGAGAACGQR RSSSSTGKVR VLRHRKSTKS 
    FNMMSPTGDN SELLAEIKAG KSLKPTPQSK GLTTVFSGSG QPASQPESPQ PLVSPAPSRT 
    RSPTPPASGS QPLLNGSVVP APPATPAPGV HLDVEALIPT LDEQGRPIPE WKRQVMVRKL 
    QQKMQEEEEQ RRKEEEEEAR LASLPAWRRD ILRKKLEEER EQKRKEEERQ KLEEIQRAKE 
    QSEKLRTLGY DEAKLAPWQR QVILKKGEIP K

Genular Protein ID: 1600010352

Symbol: Q9DD12_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 253
  • Mass: 28097
  • Checksum: 97AE5A133470F487
  • Sequence:
  • MNSQGPLGGG HIPSTKSFNM MSPTGDNSEL LAEIKAGKSL KPTPQSKGLT TVFSGSGQPA 
    SQVGTGRVPR PGSQCLPSAQ PYCFSRQPES PQPLVSPAPS RTRSPTPPAS GSQPLLNGSV 
    VPAPPATPAP GVHLDVEALI PTLDEQGRPI PEWKRQVMVR KLQQKMQEEE EQRRKEEEEE 
    ARLASLPAWR RDILRKKLEE EREQKRKEEE RQKLEEIQRA KEQSEKLRTL GYDEAKLAPW 
    QRQVILKKGE IPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.