Details for: MRAP

Gene ID: 56246

Symbol: MRAP

Ensembl ID: ENSG00000170262

Description: melanocortin 2 receptor accessory protein

Associated with

  • Corticotropin hormone receptor binding
    (GO:0031780)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Identical protein binding
    (GO:0042802)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106072)
  • Negative regulation of protein localization to plasma membrane
    (GO:1903077)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106071)
  • Protein binding
    (GO:0005515)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106070)
  • Signaling receptor regulator activity
    (GO:0030545)
  • Type 1 melanocortin receptor binding
    (GO:0070996)
  • Type 3 melanocortin receptor binding
    (GO:0031781)
  • Type 4 melanocortin receptor binding
    (GO:0031782)
  • Type 5 melanocortin receptor binding
    (GO:0031783)

Other Information

Genular Protein ID: 1450953234

Symbol: MRAP_HUMAN

Name: Melanocortin-2 receptor accessory protein

UniProtKB Accession Codes:

Q8TCY5 Q5EBR3 Q8TDB7 Q8WXC1 Q8WXC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 16 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12054497

Title: Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells.

PubMed ID: 12054497

DOI: 10.1016/s0006-291x(02)00354-6

PubMed ID: 12036298

Title: Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.

PubMed ID: 12036298

DOI: 10.1006/geno.2002.6782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19329486

Title: MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

PubMed ID: 19329486

DOI: 10.1073/pnas.0809918106

PubMed ID: 20371771

Title: Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.

PubMed ID: 20371771

DOI: 10.1126/scisignal.2000593

PubMed ID: 15654338

Title: Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.

PubMed ID: 15654338

DOI: 10.1038/ng1501

Sequence Information:

  • Length: 172
  • Mass: 19136
  • Checksum: 9F93F39B40FAAFEA
  • Sequence:
    • MANGTNASAP YYSYEYYLDY LDLIPVDEKK LKAHKHSIVI AFWVSLAAFV VLLFLILLYM 
SWSASPQMRN SPKHHQTCPW SHGLNLHLCI QKCLPCHREP LATSQAQASS VEPGSRTGPD 
QPLRQESSST LPLGGFQTHP TLLWELTLNG GPLVRSKPSE PPPGDRTSQL QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.