PRODH | ENSG00000100033 | NCBI 5625

Details for: PRODH

Gene ID: 5625

Symbol: PRODH

Ensembl ID: ENSG00000100033

Description: proline dehydrogenase 1

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Proline catabolism
(R-HSA-70688)
4-hydroxyproline catabolic process
(GO:0019470)
Fad binding
(GO:0071949)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nucleoplasm
(GO:0005654)
Proline catabolic process
(GO:0006562)
Proline catabolic process to glutamate
(GO:0010133)
Proline dehydrogenase activity
(GO:0004657)
Proline metabolic process
(GO:0006560)
Regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903376)

Other Information

Proteins

Proline oxidase

Genular Protein ID: 474965106

Symbol: PROD_HUMAN

Name: Proline oxidase

UniProtKB Accession Codes:

O43272 A6NF53 O14680 Q0P507 Q147W8 Q504W1 Q59FI8 Q6NV86 Q9UF13

Database IDs:

Citations:

PubMed ID: 9385373

Title: A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia.

PubMed ID: 9385373

DOI: 10.1007/s004390050589

PubMed ID: 10192398

Title: The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.

PubMed ID: 10192398

DOI: 10.1038/7777

PubMed ID: 15662599

Title: Functional consequences of PRODH missense mutations.

PubMed ID: 15662599

DOI: 10.1086/428142

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9305847

Title: A model for p53-induced apoptosis.

PubMed ID: 9305847

DOI: 10.1038/38525

PubMed ID: 12217952

Title: PRODH mutations and hyperprolinemia in a subset of schizophrenic patients.

PubMed ID: 12217952

DOI: 10.1093/hmg/11.19.2243

PubMed ID: 11891283

Title: Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia.

PubMed ID: 11891283

DOI: 10.1073/pnas.042700699

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17135275

Title: Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome.

PubMed ID: 17135275

DOI: 10.1093/hmg/ddl443

Sequence Information:

Length: 600
Mass: 68002
Checksum: 249E98A0A5BB8027
Sequence:

MALRRALPAL RPCIPRFVQL STAPASREQP AAGPAAVPGG GSATAVRPPV PAVDFGNAQE 
AYRSRRTWEL ARSLLVLRLC AWPALLARHE QLLYVSRKLL GQRLFNKLMK MTFYGHFVAG 
EDQESIQPLL RHYRAFGVSA ILDYGVEEDL SPEEAEHKEM ESCTSAAERD GSGTNKRDKQ 
YQAHRAFGDR RNGVISARTY FYANEAKCDS HMETFLRCIE ASGRVSDDGF IAIKLTALGR 
PQFLLQFSEV LAKWRCFFHQ MAVEQGQAGL AAMDTKLEVA VLQESVAKLG IASRAEIEDW 
FTAETLGVSG TMDLLDWSSL IDSRTKLSKH LVVPNAQTGQ LEPLLSRFTE EEELQMTRML 
QRMDVLAKKA TEMGVRLMVD AEQTYFQPAI SRLTLEMQRK FNVEKPLIFN TYQCYLKDAY 
DNVTLDVELA RREGWCFGAK LVRGAYLAQE RARAAEIGYE DPINPTYEAT NAMYHRCLDY 
VLEELKHNAK AKVMVASHNE DTVRFALRRM EELGLHPADH QVYFGQLLGM CDQISFPLGQ 
AGYPVYKYVP YGPVMEVLPY LSRRALENSS LMKGTHRERQ LLWLELLRRL RTGNLFHRPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRODH

Associated with

Other Information

A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia. PubMed ID: 9385373

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. PubMed ID: 10192398

Functional consequences of PRODH missense mutations. PubMed ID: 15662599

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A model for p53-induced apoptosis. PubMed ID: 9305847

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. PubMed ID: 12217952

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. PubMed ID: 11891283

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. PubMed ID: 17135275