Details for: CRTAM

Gene ID: 56253

Symbol: CRTAM

Ensembl ID: ENSG00000109943

Description: cytotoxic and regulatory T cell molecule

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Activated t cell proliferation
    (GO:0050798)
  • Cell recognition
    (GO:0008037)
  • Detection of stimulus
    (GO:0051606)
  • Detection of tumor cell
    (GO:0002355)
  • Establishment of t cell polarity
    (GO:0001768)
  • Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
    (GO:0007157)
  • Immunological synapse
    (GO:0001772)
  • Lymphocyte migration into lymphoid organs
    (GO:0097021)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
    (GO:0002860)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001185)
  • Regulation of t cell activation
    (GO:0050863)
  • Regulation of t cell differentiation
    (GO:0045580)
  • Signaling receptor binding
    (GO:0005102)
  • T cell mediated cytotoxicity
    (GO:0001913)

Other Information

Genular Protein ID: 3458578019

Symbol: CRTAM_HUMAN

Name: Cytotoxic and regulatory T-cell molecule

UniProtKB Accession Codes:

O95727 Q59EI1 Q6IRX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10811014

Title: A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM).

PubMed ID: 10811014

DOI: 10.1002/jlb.67.5.725

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15811952

Title: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.

PubMed ID: 15811952

DOI: 10.1182/blood-2005-02-0817

PubMed ID: 15781451

Title: Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.

PubMed ID: 15781451

DOI: 10.1074/jbc.m502095200

PubMed ID: 16300832

Title: Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes.

PubMed ID: 16300832

DOI: 10.1016/j.jneuroim.2005.09.017

PubMed ID: 23583034

Title: Functional classification of immune regulatory proteins.

PubMed ID: 23583034

DOI: 10.1016/j.str.2013.02.022

PubMed ID: 23871486

Title: Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2.

PubMed ID: 23871486

DOI: 10.1016/j.str.2013.06.006

Sequence Information:

  • Length: 393
  • Mass: 44641
  • Checksum: CB8173032EE45F03
  • Sequence:
    • MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL 
NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK 
PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT 
STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ 
PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI 
LFIIVQLFIM KLRKAHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ SSHPMRCMNY 
ITKLYSEAKT KRKENVQHSK LEEKHIQVPE SIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.