Details for: LRRC8A
Associated with
Other Information
Genular Protein ID: 155435418
Symbol: LRC8A_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14660746
Title: A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans.
PubMed ID: 14660746
DOI: 10.1172/jci18937
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15183935
Title: LRRC8 extracellular domain is composed of 17 leucine-rich repeats.
PubMed ID: 15183935
PubMed ID: 22532330
Title: LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.
PubMed ID: 22532330
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24725410
Title: SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.
PubMed ID: 24725410
PubMed ID: 24782309
Title: The protein synthesis inhibitor blasticidin S enters mammalian cells via leucine-rich repeat-containing protein 8D.
PubMed ID: 24782309
PubMed ID: 24790029
Title: Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
PubMed ID: 24790029
PubMed ID: 26530471
Title: Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
PubMed ID: 26530471
PubMed ID: 26824658
Title: LRRC8 proteins form volume-regulated anion channels that sense ionic strength.
PubMed ID: 26824658
PubMed ID: 28193731
Title: Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
PubMed ID: 28193731
DOI: 10.1242/jcs.196253
PubMed ID: 29925591
Title: LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs).
PubMed ID: 29925591
PubMed ID: 29769723
Title: Structure of a volume-regulated anion channel of the LRRC8 family.
PubMed ID: 29769723
PubMed ID: 29371604
Title: SWELL1 is a glucose sensor regulating beta-cell excitability and systemic glycaemia.
PubMed ID: 29371604
PubMed ID: 31270356
Title: CRISPR knockout screen implicates three genes in lysosome function.
PubMed ID: 31270356
PubMed ID: 33171122
Title: LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP.
PubMed ID: 33171122
PubMed ID: 33139539
Title: LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.
PubMed ID: 33139539
PubMed ID: 30095067
Title: Structure of the human volume regulated anion channel.
PubMed ID: 30095067
DOI: 10.7554/elife.38461
PubMed ID: 30127360
Title: Cryo-EM structures of the human volume-regulated anion channel LRRC8.
PubMed ID: 30127360
PubMed ID: 30135305
Title: Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.
PubMed ID: 30135305
Sequence Information:
- Length: 810
- Mass: 94199
- Checksum: E0C5E6EBEE8275E8
- Sequence:
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV TKDSCNDSFR GWAAPGPEPT YPNSTILPTP DTGPTGIKYD LDRHQYNYVD AVCYENRLHW FAKYFPYLVL LHTLIFLACS NFWFKFPRTS SKLEHFVSIL LKCFDSPWTT RALSETVVEE SDPKPAFSKM NGSMDKKSST VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA KALFEKVKKF RTHVEEGDIV YRLYMRQTII KVIKFILIIC YTVYYVHNIK FDVDCTVDIE SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK YSFESIREES SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN KLRQLNLNNE WTLDKLRQRL TKNAQDKLEL HLFMLSGIPD TVFDLVELEV LKLELIPDVT IPPSIAQLTG LKELWLYHTA AKIEAPALAF LRENLRALHI KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL RELKRLKVLR LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM ANLTELELIR CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH IAYIPIQIGN LTNLERLYLN RNKIEKIPTQ LFYCRKLRYL DLSHNNLTFL PADIGLLQNL QNLAITANRI ETLPPELFQC RKLRALHLGN NVLQSLPSRV GELTNLTQIE LRGNRLECLP VELGECPLLK RSGLVVEEDL FNTLPPEVKE RLWRADKEQA
Genular Protein ID: 2074642029
Symbol: A8K1C7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 810
- Mass: 94173
- Checksum: 42D84E6D3E6901AD
- Sequence:
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMFAV FGGTLQVTQD KMICLPCKWV TKDSCNDSFR GWAAPGPEPT YPNSTILPTP DTGPTGIKYD LDRHQYNYVD AVCYENRLHW FAKYFPYLVL LHTLIFLACS NFWFKFPRTS SKLEHFVSIL LKCFDSPWTT RALSETVVEE SDPKPAFSKM NGSMDKKSST VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA KALFEKVKKF RTHVEEGDIV YRLYMRQTII KVIKFILIIC YTVYYVHNIK FDVDCTVDIE SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK YSFESIREES SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN KLRQLNLNNE WTLDKLRQRL TKNAQDKLEL HLFMLSGIPD TVFDLVELEV LKLELIPDVT IPPSIAQLTG LKELWLYHTA AKIEAPALAF LRENLRALHI KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL RELKRLKVLR LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM ANLTELELIR CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH IAYIPIQIGN LTNLERLYLN RNKIEKIPTQ LSYCRKLRYL DLSHNNLTFL PADIGLLQNL QNLAITANRI ETLPPELFQC RKLRALHLGN NVLQSLPSRV GELTNLTQIE LRGNRLECLP VELGECPLLK RSGLVVEEDL FNTLPPEVKE RLWRADKEQA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.