Details for: WDR45B

Gene ID: 56270

Symbol: WDR45B

Ensembl ID: ENSG00000141580

Description: WD repeat domain 45B

Associated with

Other Information

Genular Protein ID: 3857327055

Symbol: WIPI3_HUMAN

Name: WD repeat domain phosphoinositide-interacting protein 3

UniProtKB Accession Codes:

Q5MNZ6 A0A024R8U4 A0A218N098 O95328 Q2MCP6 Q6IBN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15602573

Title: WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

PubMed ID: 15602573

DOI: 10.1038/sj.onc.1208331

PubMed ID: 28503735

Title: WDR45B-related intellectual disability, spastic quadriplegia, epilepsy, and cerebral hypoplasia: A consistent neurodevelopmental syndrome.

PubMed ID: 28503735

DOI: 10.1111/cge.13054

PubMed ID: 30797857

Title: Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins.

PubMed ID: 30797857

DOI: 10.1016/j.jmb.2019.02.019

PubMed ID: 32483132

Title: Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.

PubMed ID: 32483132

DOI: 10.1038/s41467-020-16523-y

Sequence Information:

  • Length: 344
  • Mass: 38122
  • Checksum: CC60535E1D28660C
  • Sequence:
    • MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML 
FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI 
KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD 
IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ 
DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA 
FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.