Stk3 | ENSMUSG00000022329 | NCBI 56274

Details for: Stk3

Gene ID: 56274

Symbol: Stk3

Ensembl ID: ENSMUSG00000022329

Description: serine/threonine kinase 3

Associated with

Signaling by hippo
(R-MMU-2028269)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Canonical wnt signaling pathway
(GO:0060070)
Cell differentiation involved in embryonic placenta development
(GO:0060706)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Endocardium development
(GO:0003157)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Hepatocyte apoptotic process
(GO:0097284)
Hippo signaling
(GO:0035329)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of organ growth
(GO:0046621)
Neural tube formation
(GO:0001841)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Organ growth
(GO:0035265)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902043)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein binding
(GO:0032092)
Primitive hemopoiesis
(GO:0060215)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein kinase activity
(GO:0004672)
Protein localization to centrosome
(GO:0071539)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein stabilization
(GO:0050821)
Protein tetramerization
(GO:0051262)
Regulation of cell differentiation involved in embryonic placenta development
(GO:0060800)
Regulation of mapk cascade
(GO:0043408)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase 3

Genular Protein ID: 915659835

Symbol: STK3_MOUSE

Name: Serine/threonine-protein kinase 3

UniProtKB Accession Codes:

Q9JI10 Q60877 Q80UG4 Q8CI58

Database IDs:

Citations:

PubMed ID: 11278283

Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.

PubMed ID: 11278283

DOI: 10.1074/jbc.m005109200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20080689

Title: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

PubMed ID: 20080689

DOI: 10.1073/pnas.0911427107

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

Sequence Information:

Length: 497
Mass: 56855
Checksum: 9CDD365437581665
Sequence:

MEQPPASKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLTE 
DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT 
VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT 
FRKPELWSDD FTDFVKKCLV KSPEQRATAT QLLQHPFIKN AKPVSILRDL IAEAMEIKAK 
RHEEQQRELE EEEENSDEDE LDSHTMVKTS SESVGTMRAT STMSEGAQTM IEHNSTMLES 
DLGTMVINSE EEEEEEEEEE EDGTMKRNAT SPQVQRPSFM DYFDKQDFKN KSHENCDQSM 
REPGPMSNSV FPDNWRVPQD GDFDFLKNLS LEELQMRLKA LDPMMEREIE ELHQRYSAKR 
QPILDAMDAK KRRQQNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stk3

Associated with

Other Information

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. PubMed ID: 11278283

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. PubMed ID: 20080689

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. PubMed ID: 28087714