PARD3 | ENSG00000148498 | NCBI 56288

Details for: PARD3

Gene ID: 56288

Symbol: PARD3

Ensembl ID: ENSG00000148498

Description: par-3 family cell polarity regulator

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-HSA-2173791)
Tight junction interactions
(R-HSA-420029)
Adherens junction
(GO:0005912)
Apical junction complex
(GO:0043296)
Apical plasma membrane
(GO:0016324)
Asymmetric cell division
(GO:0008356)
Axonogenesis
(GO:0007409)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell cortex
(GO:0005938)
Cell cycle
(GO:0007049)
Cell junction
(GO:0030054)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endomembrane system
(GO:0012505)
Establishment of cell polarity
(GO:0030010)
Establishment of centrosome localization
(GO:0051660)
Establishment of epithelial cell polarity
(GO:0090162)
Establishment or maintenance of cell polarity
(GO:0007163)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Internode region of axon
(GO:0033269)
Microtubule cytoskeleton organization
(GO:0000226)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Par polarity complex
(GO:0120157)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol-3-phosphate binding
(GO:0032266)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylinositol binding
(GO:0035091)
Plasma membrane
(GO:0005886)
Positive regulation of myelination
(GO:0031643)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein localization
(GO:0008104)
Protein targeting to membrane
(GO:0006612)
Tight junction
(GO:0070160)

Other Information

Proteins

Partitioning defective 3 homolog

Genular Protein ID: 71389152

Symbol: PARD3_HUMAN

Name: Partitioning defective 3 homolog

UniProtKB Accession Codes:

Q8TEW0 F5H5T0 Q5T2U1 Q5VUA2 Q5VUA3 Q5VWV0 Q5VWV1 Q5VWV3 Q5VWV4 Q5VWV5 Q6IQ47 Q8TCZ9 Q8TEW1 Q8TEW2 Q8TEW3 Q96K28 Q96RM6 Q96RM7 Q9BY57 Q9BY58 Q9HC48 Q9NWL4 Q9NYE6

Database IDs:

Citations:

PubMed ID: 10934474

Title: The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.

PubMed ID: 10934474

DOI: 10.1038/35019573

PubMed ID: 11642408

Title: Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas.

PubMed ID: 11642408

DOI: 10.1038/sj.cr.7290090

PubMed ID: 12459187

Title: PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.

PubMed ID: 12459187

DOI: 10.1016/s0006-291x(02)02698-0

PubMed ID: 12234671

Title: Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.

PubMed ID: 12234671

DOI: 10.1016/s0378-1119(02)00681-9

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11149944

Title: Serological detection of cutaneous T-cell lymphoma-associated antigens.

PubMed ID: 11149944

DOI: 10.1073/pnas.98.2.629

PubMed ID: 10954424

Title: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.

PubMed ID: 10954424

DOI: 10.1242/jcs.113.18.3267

PubMed ID: 11257119

Title: Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

PubMed ID: 11257119

DOI: 10.1083/jcb.152.6.1183

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15254234

Title: Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.

PubMed ID: 15254234

DOI: 10.1128/mcb.24.15.6665-6675.2004

PubMed ID: 16678097

Title: A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.

PubMed ID: 16678097

DOI: 10.1016/j.cell.2006.02.045

PubMed ID: 18838552

Title: The keratin-binding protein Albatross regulates polarization of epithelial cells.

PubMed ID: 18838552

DOI: 10.1083/jcb.200803133

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19812038

Title: Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity.

PubMed ID: 19812038

DOI: 10.1074/jbc.m109.055897

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21949390

Title: Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.

PubMed ID: 21949390

DOI: 10.1073/pnas.1104969108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23832200

Title: High-resolution structure of the Tiam1 PHn-CC-Ex domain.

PubMed ID: 23832200

DOI: 10.1107/s1744309113014206

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26766442

Title: SAPCD2 controls spindle orientation and asymmetric divisions by negatively regulating the Galphai-LGN-NuMA ternary complex.

PubMed ID: 26766442

DOI: 10.1016/j.devcel.2015.12.016

PubMed ID: 27925688

Title: Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation.

PubMed ID: 27925688

DOI: 10.1002/humu.23153

PubMed ID: 20073081

Title: Rapid, robotic, small-scale protein production for NMR screening and structure determination.

PubMed ID: 20073081

DOI: 10.1002/pro.335

Sequence Information:

Length: 1356
Mass: 151423
Checksum: A4FD3F4F9AD8B92A
Sequence:

MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD 
LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ 
ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL 
KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE 
DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG 
LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA 
ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR 
LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV 
TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV 
SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG 
LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME 
TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS 
GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS 
SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS 
QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV 
TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR 
ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL 
GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ ERIQAKTREF RERQARERDY 
AEIQDFHRTF GCDDELMYGG VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP 
VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE 
VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS 
SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS 
YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PARD3

Associated with

Other Information

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. PubMed ID: 10934474

Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas. PubMed ID: 11642408

PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. PubMed ID: 12459187

Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. PubMed ID: 12234671

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Serological detection of cutaneous T-cell lymphoma-associated antigens. PubMed ID: 11149944

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. PubMed ID: 10954424

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. PubMed ID: 11257119

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. PubMed ID: 15254234

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. PubMed ID: 16678097

The keratin-binding protein Albatross regulates polarization of epithelial cells. PubMed ID: 18838552

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity. PubMed ID: 19812038

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

CCM1 regulates vascular-lumen organization by inducing endothelial polarity. PubMed ID: 20332120

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. PubMed ID: 21949390

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

High-resolution structure of the Tiam1 PHn-CC-Ex domain. PubMed ID: 23832200

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SAPCD2 controls spindle orientation and asymmetric divisions by negatively regulating the Galphai-LGN-NuMA ternary complex. PubMed ID: 26766442

Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation. PubMed ID: 27925688

Rapid, robotic, small-scale protein production for NMR screening and structure determination. PubMed ID: 20073081