Details for: AZGP1

Gene ID: 563

Symbol: AZGP1

Ensembl ID: ENSG00000160862

Description: alpha-2-glycoprotein 1, zinc-binding

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.8658
    Cell Significance Index: -20.2000
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 65.4107
    Cell Significance Index: 32.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 42.7302
    Cell Significance Index: 262.9700
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 35.8768
    Cell Significance Index: 199.6900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 25.7094
    Cell Significance Index: 67.8200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 25.2294
    Cell Significance Index: 18.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 24.4068
    Cell Significance Index: 1137.9600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 22.3416
    Cell Significance Index: 465.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 13.0731
    Cell Significance Index: 974.3300
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 12.4331
    Cell Significance Index: 53.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 7.1656
    Cell Significance Index: 120.7100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 6.9517
    Cell Significance Index: 71.9400
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 6.6985
    Cell Significance Index: 44.7300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.6583
    Cell Significance Index: 34.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.6297
    Cell Significance Index: 598.1300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.5014
    Cell Significance Index: 45.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3758
    Cell Significance Index: -13.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7367
    Cell Significance Index: 175.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.5002
    Cell Significance Index: 29.7500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.4406
    Cell Significance Index: 3.1600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 2.4193
    Cell Significance Index: 24.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.3473
    Cell Significance Index: 39.4800
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 2.2913
    Cell Significance Index: 16.0800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.7061
    Cell Significance Index: 9.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6239
    Cell Significance Index: 176.6300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.3901
    Cell Significance Index: 6.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3726
    Cell Significance Index: 20.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2798
    Cell Significance Index: 22.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1502
    Cell Significance Index: 69.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9207
    Cell Significance Index: 25.0600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.9054
    Cell Significance Index: 3.4100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.8991
    Cell Significance Index: 6.4700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.8693
    Cell Significance Index: 5.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8153
    Cell Significance Index: 56.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7471
    Cell Significance Index: 142.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6807
    Cell Significance Index: 116.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6325
    Cell Significance Index: 102.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4021
    Cell Significance Index: 79.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1603
    Cell Significance Index: 15.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1538
    Cell Significance Index: 4.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1319
    Cell Significance Index: 23.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0899
    Cell Significance Index: 68.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0817
    Cell Significance Index: 9.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0808
    Cell Significance Index: 2.8400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0699
    Cell Significance Index: 0.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0507
    Cell Significance Index: 6.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0132
    Cell Significance Index: 1.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0048
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0064
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0103
    Cell Significance Index: -19.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0147
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0187
    Cell Significance Index: -34.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0223
    Cell Significance Index: -34.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0235
    Cell Significance Index: -17.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0252
    Cell Significance Index: -16.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0273
    Cell Significance Index: -17.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0278
    Cell Significance Index: -20.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0303
    Cell Significance Index: -13.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0306
    Cell Significance Index: -8.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0358
    Cell Significance Index: -19.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0406
    Cell Significance Index: -1.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0438
    Cell Significance Index: -15.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0447
    Cell Significance Index: -4.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0509
    Cell Significance Index: -23.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0744
    Cell Significance Index: -3.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0821
    Cell Significance Index: -10.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0918
    Cell Significance Index: -18.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1009
    Cell Significance Index: -11.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1092
    Cell Significance Index: -23.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1164
    Cell Significance Index: -2.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1205
    Cell Significance Index: -2.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1346
    Cell Significance Index: -19.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1395
    Cell Significance Index: -2.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1443
    Cell Significance Index: -2.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1495
    Cell Significance Index: -20.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1538
    Cell Significance Index: -2.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1718
    Cell Significance Index: -20.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1833
    Cell Significance Index: -14.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2017
    Cell Significance Index: -21.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2135
    Cell Significance Index: -15.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2559
    Cell Significance Index: -16.1300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2564
    Cell Significance Index: -1.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2586
    Cell Significance Index: -17.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2613
    Cell Significance Index: -5.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2644
    Cell Significance Index: -16.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2767
    Cell Significance Index: -11.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2801
    Cell Significance Index: -14.5500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.3089
    Cell Significance Index: -2.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3229
    Cell Significance Index: -19.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3439
    Cell Significance Index: -9.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3896
    Cell Significance Index: -21.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3969
    Cell Significance Index: -14.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4212
    Cell Significance Index: -12.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4627
    Cell Significance Index: -6.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4723
    Cell Significance Index: -7.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4753
    Cell Significance Index: -11.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4756
    Cell Significance Index: -11.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AZGP1 is a secreted glycoprotein that is primarily expressed in exocrine glands, such as the salivary gland, pancreas, mammary gland, and prostate gland. Its expression is also observed in immune cells, indicating a potential role in immune modulation. AZGP1 is characterized by its ability to bind zinc ions, which is crucial for its function. The protein is highly conserved across species, suggesting its evolutionary importance. **Pathways and Functions:** AZGP1 is involved in various cellular processes, including: 1. **Cell adhesion:** AZGP1 interacts with integrins and other adhesion molecules, facilitating cell-cell and cell-matrix interactions. This process is essential for maintaining tissue architecture and regulating cell migration. 2. **Immune response:** AZGP1 modulates immune responses by regulating the activity of immune cells, such as T cells and macrophages. Its expression is induced by inflammatory cytokines, suggesting a role in immune homeostasis. 3. **Sensory perception:** AZGP1 is involved in the detection of chemical stimuli, particularly bitter taste. Its expression in taste buds and olfactory epithelium highlights its role in sensory perception. 4. **Extracellular matrix:** AZGP1 interacts with collagen and other extracellular matrix components, influencing matrix remodeling and cell migration. **Clinical Significance:** AZGP1 has been implicated in various human diseases, including: 1. **Prostate cancer:** Elevated AZGP1 expression has been observed in prostate cancer tissues, suggesting its potential role as a biomarker for early detection. 2. **Pancreatic cancer:** AZGP1 expression is also increased in pancreatic cancer tissues, indicating its involvement in tumor progression. 3. **Autoimmune diseases:** AZGP1 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it modulates immune responses and tissue damage. 4. **Neurological disorders:** AZGP1 expression has been altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in neuroinflammation and degeneration. In conclusion, AZGP1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, immune response, and sensory perception. Its clinical significance is evident in its association with human diseases, highlighting the need for further research to fully understand its functions and potential therapeutic applications.

Genular Protein ID: 258717831

Symbol: ZA2G_HUMAN

Name: Zinc-alpha-2-glycoprotein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1915885

Title: Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues.

PubMed ID: 1915885

DOI: 10.1016/0014-5793(91)81271-9

PubMed ID: 8241150

Title: Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein.

PubMed ID: 8241150

DOI: 10.1021/bi00211a004

PubMed ID: 8307568

Title: Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes.

PubMed ID: 8307568

DOI: 10.1016/s0888-7543(05)80359-3

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2049092

Title: Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene.

PubMed ID: 2049092

DOI: 10.1016/0006-291x(91)91844-3

PubMed ID: 3422450

Title: Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens.

PubMed ID: 3422450

DOI: 10.1073/pnas.85.3.679

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9114041

Title: Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog.

PubMed ID: 9114041

DOI: 10.1073/pnas.94.9.4626

PubMed ID: 11425849

Title: Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins.

PubMed ID: 11425849

DOI: 10.1074/jbc.c100301200

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10206894

Title: Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.

PubMed ID: 10206894

DOI: 10.1126/science.283.5409.1914

PubMed ID: 15477100

Title: Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.

PubMed ID: 15477100

DOI: 10.1016/j.jsb.2004.04.009

PubMed ID: 18930737

Title: Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma.

PubMed ID: 18930737

DOI: 10.1016/j.jmb.2008.09.072

Sequence Information:

  • Length: 298
  • Mass: 34259
  • Checksum: 006A153A8E32A0B1
  • Sequence:
  • MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR 
    YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR 
    FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA 
    YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT 
    RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.