Details for: AZGP1

Gene ID: 563

Symbol: AZGP1

Ensembl ID: ENSG00000160862

Description: alpha-2-glycoprotein 1, zinc-binding

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.43
    Marker Score: 10,089
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.12
    Marker Score: 8,698
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.51
    Marker Score: 13,535
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.45
    Marker Score: 1,377
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.43
    Marker Score: 2,000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.21
    Marker Score: 1,661
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.11
    Marker Score: 984
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.07
    Marker Score: 16,527
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.75
    Marker Score: 4,880
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.72
    Marker Score: 2,429
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.66
    Marker Score: 944
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.53
    Marker Score: 923
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.5
    Marker Score: 1,408
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.38
    Marker Score: 997
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.22
    Marker Score: 828
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.22
    Marker Score: 1,542
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.13
    Marker Score: 9,183
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1
    Marker Score: 13,494
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.06
    Marker Score: 962
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.04
    Marker Score: 1,604
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.75
    Marker Score: 849
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.6
    Marker Score: 1,716
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.53
    Marker Score: 3,743
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.52
    Marker Score: 472
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,686
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.37
    Marker Score: 1,037
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.28
    Marker Score: 2,908
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.24
    Marker Score: 4,421
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.19
    Marker Score: 798
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.17
    Marker Score: 299
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.15
    Marker Score: 568
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 759
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.08
    Marker Score: 1,828
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.08
    Marker Score: 716
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.07
    Marker Score: 555
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.06
    Marker Score: 592
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1
    Marker Score: 248
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.94
    Marker Score: 260
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,306
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.92
    Marker Score: 640
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.91
    Marker Score: 623
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.86
    Marker Score: 249
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 195
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.84
    Marker Score: 1,358
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.84
    Marker Score: 1,205
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13,120
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.82
    Marker Score: 311
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.82
    Marker Score: 2,686
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1,501
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.78
    Marker Score: 5,107
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.78
    Marker Score: 1,287
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.75
    Marker Score: 10,137
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 498
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.75
    Marker Score: 280
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,015
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1,691
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.68
    Marker Score: 4,330
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.67
    Marker Score: 699
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.64
    Marker Score: 1,025
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.64
    Marker Score: 571
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.64
    Marker Score: 1,160
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.62
    Marker Score: 5,242
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.62
    Marker Score: 723
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.62
    Marker Score: 214
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 390
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.61
    Marker Score: 170
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.6
    Marker Score: 143
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.56
    Marker Score: 2,687
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.55
    Marker Score: 339
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.55
    Marker Score: 528
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.54
    Marker Score: 12,063
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.54
    Marker Score: 1,273
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1,084
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.53
    Marker Score: 116
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 289
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.48
    Marker Score: 137
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.45
    Marker Score: 2,368
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.45
    Marker Score: 440
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.45
    Marker Score: 714
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.45
    Marker Score: 656
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.44
    Marker Score: 166

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AZGP1 is a secreted glycoprotein that is primarily expressed in exocrine glands, such as the salivary gland, pancreas, mammary gland, and prostate gland. Its expression is also observed in immune cells, indicating a potential role in immune modulation. AZGP1 is characterized by its ability to bind zinc ions, which is crucial for its function. The protein is highly conserved across species, suggesting its evolutionary importance. **Pathways and Functions:** AZGP1 is involved in various cellular processes, including: 1. **Cell adhesion:** AZGP1 interacts with integrins and other adhesion molecules, facilitating cell-cell and cell-matrix interactions. This process is essential for maintaining tissue architecture and regulating cell migration. 2. **Immune response:** AZGP1 modulates immune responses by regulating the activity of immune cells, such as T cells and macrophages. Its expression is induced by inflammatory cytokines, suggesting a role in immune homeostasis. 3. **Sensory perception:** AZGP1 is involved in the detection of chemical stimuli, particularly bitter taste. Its expression in taste buds and olfactory epithelium highlights its role in sensory perception. 4. **Extracellular matrix:** AZGP1 interacts with collagen and other extracellular matrix components, influencing matrix remodeling and cell migration. **Clinical Significance:** AZGP1 has been implicated in various human diseases, including: 1. **Prostate cancer:** Elevated AZGP1 expression has been observed in prostate cancer tissues, suggesting its potential role as a biomarker for early detection. 2. **Pancreatic cancer:** AZGP1 expression is also increased in pancreatic cancer tissues, indicating its involvement in tumor progression. 3. **Autoimmune diseases:** AZGP1 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it modulates immune responses and tissue damage. 4. **Neurological disorders:** AZGP1 expression has been altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in neuroinflammation and degeneration. In conclusion, AZGP1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, immune response, and sensory perception. Its clinical significance is evident in its association with human diseases, highlighting the need for further research to fully understand its functions and potential therapeutic applications.

Genular Protein ID: 258717831

Symbol: ZA2G_HUMAN

Name: Zinc-alpha-2-glycoprotein

UniProtKB Accession Codes:

P25311 D6W5T8 O60386 Q5XKQ4 Q8N4N0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 11 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 9 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1915885

Title: Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues.

PubMed ID: 1915885

DOI: 10.1016/0014-5793(91)81271-9

PubMed ID: 8241150

Title: Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein.

PubMed ID: 8241150

DOI: 10.1021/bi00211a004

PubMed ID: 8307568

Title: Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes.

PubMed ID: 8307568

DOI: 10.1016/s0888-7543(05)80359-3

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2049092

Title: Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene.

PubMed ID: 2049092

DOI: 10.1016/0006-291x(91)91844-3

PubMed ID: 3422450

Title: Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens.

PubMed ID: 3422450

DOI: 10.1073/pnas.85.3.679

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9114041

Title: Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog.

PubMed ID: 9114041

DOI: 10.1073/pnas.94.9.4626

PubMed ID: 11425849

Title: Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins.

PubMed ID: 11425849

DOI: 10.1074/jbc.c100301200

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10206894

Title: Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.

PubMed ID: 10206894

DOI: 10.1126/science.283.5409.1914

PubMed ID: 15477100

Title: Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.

PubMed ID: 15477100

DOI: 10.1016/j.jsb.2004.04.009

PubMed ID: 18930737

Title: Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma.

PubMed ID: 18930737

DOI: 10.1016/j.jmb.2008.09.072

Sequence Information:

  • Length: 298
  • Mass: 34259
  • Checksum: 006A153A8E32A0B1
  • Sequence:
    • MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR 
YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR 
FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA 
YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT 
RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.