Gps2 | ENSMUSG00000023170 | NCBI 56310

Details for: Gps2

Gene ID: 56310

Symbol: Gps2

Ensembl ID: ENSMUSG00000023170

Description: G protein pathway suppressor 2

Associated with

Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Hdacs deacetylate histones
(R-MMU-3214815)
Nr1h2 and nr1h3-mediated signaling
(R-MMU-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-MMU-9029569)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
B cell differentiation
(GO:0030183)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Mitochondrion
(GO:0005739)
Negative regulation of b cell receptor signaling pathway
(GO:0050859)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of protein k63-linked ubiquitination
(GO:1900045)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to mitochondrial depolarisation
(GO:0098780)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)

Other Information

Proteins

GPS2_MOUSE

Genular Protein ID: 449983797

Symbol: GPS2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q921N8

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18218630

Title: G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.

PubMed ID: 18218630

DOI: 10.1074/jbc.m708209200

PubMed ID: 22424771

Title: A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.

PubMed ID: 22424771

DOI: 10.1016/j.molcel.2012.01.025

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 24953653

Title: GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma.

PubMed ID: 24953653

DOI: 10.1016/j.celrep.2014.05.041

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25519902

Title: The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2.

PubMed ID: 25519902

DOI: 10.1074/jbc.m114.598797

PubMed ID: 26070566

Title: Exchange factor TBL1 and arginine methyltransferase PRMT6 cooperate in protecting G protein pathway suppressor 2 (GPS2) from proteasomal degradation.

PubMed ID: 26070566

DOI: 10.1074/jbc.m115.637660

PubMed ID: 27270589

Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

PubMed ID: 27270589

DOI: 10.1038/nm.4114

PubMed ID: 28039360

Title: Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B Cell development.

PubMed ID: 28039360

DOI: 10.1074/jbc.m116.755132

PubMed ID: 28123943

Title: Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.

PubMed ID: 28123943

DOI: 10.1016/j.molmet.2016.10.007

PubMed ID: 29499132

Title: Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation.

PubMed ID: 29499132

DOI: 10.1016/j.molcel.2018.01.037

Sequence Information:

Length: 327
Mass: 36738
Checksum: 3008661CE6579F4B
Sequence:

MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM 
SLEETKEQIL KLQEKLSALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL 
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF 
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ 
TGFLQPGSTL SLQKQMEHAN QQTSFSDSSS LRPMHPQALH PAPGLLASPQ LPVQIQAAGK 
SGFATTSQPG PRLPFIQHSQ NPRFYHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gps2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. PubMed ID: 18218630

A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. PubMed ID: 22424771

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PubMed ID: 22666460

GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma. PubMed ID: 24953653

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2. PubMed ID: 25519902

Exchange factor TBL1 and arginine methyltransferase PRMT6 cooperate in protecting G protein pathway suppressor 2 (GPS2) from proteasomal degradation. PubMed ID: 26070566

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. PubMed ID: 27270589

Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B Cell development. PubMed ID: 28039360

Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. PubMed ID: 28123943

Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation. PubMed ID: 29499132