Details for: Nupr1

Gene ID: 56312

Symbol: Nupr1

Ensembl ID: ENSMUSG00000030717

Description: nuclear protein transcription regulator 1

Associated with

  • Acetyltransferase activator activity
    (GO:0010698)
  • Acute inflammatory response
    (GO:0002526)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Dna binding
    (GO:0003677)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Fibroblast proliferation
    (GO:0048144)
  • Intercellular bridge
    (GO:0045171)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Male gonad development
    (GO:0008584)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagosome assembly
    (GO:1902902)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of glycolytic process
    (GO:0045820)
  • Negative regulation of programmed necrotic cell death
    (GO:0062099)
  • Negative regulation of type b pancreatic cell proliferation
    (GO:1904691)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of neuroinflammatory response
    (GO:0150078)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of oxidative phosphorylation
    (GO:1903862)
  • Positive regulation of proteasomal protein catabolic process
    (GO:1901800)
  • Positive regulation of protein modification process
    (GO:0031401)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein-dna complex
    (GO:0032993)
  • Protein acetylation
    (GO:0006473)
  • Protein binding
    (GO:0005515)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of female gonad development
    (GO:2000194)
  • Regulation of response to endoplasmic reticulum stress
    (GO:1905897)
  • Response to toxic substance
    (GO:0009636)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription coactivator activity
    (GO:0003713)

Other Information

Genular Protein ID: 2769903660

Symbol: NUPR1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11896600

Title: p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis.

PubMed ID: 11896600

DOI: 10.1038/sj.onc.1205222

PubMed ID: 16374777

Title: Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.

PubMed ID: 16374777

DOI: 10.1002/glia.20297

PubMed ID: 18495683

Title: Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice.

PubMed ID: 18495683

DOI: 10.1095/biolreprod.108.068304

PubMed ID: 19723804

Title: The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.

PubMed ID: 19723804

DOI: 10.1242/jcs.048678

PubMed ID: 20181828

Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

PubMed ID: 20181828

DOI: 10.1091/mbc.e09-09-0818

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

PubMed ID: 23900510

Title: Nupr1 deletion protects against glucose intolerance by increasing beta cell mass.

PubMed ID: 23900510

DOI: 10.1007/s00125-013-3006-x

PubMed ID: 27451286

Title: Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo.

PubMed ID: 27451286

DOI: 10.1681/asn.2015080936

Sequence Information:

  • Length: 80
  • Mass: 8901
  • Checksum: 8AF6CEF99F66ED67
  • Sequence:
  • MATLPPTANP SQQPLNLEDE DGILDEYDQY SLAHPCVVGG GRKGRTKREA AANTNRPSPG 
    GHERKLLTKF QNSERKKAWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.