Stam2 | ENSMUSG00000055371 | NCBI 56324

Details for: Stam2

Gene ID: 56324

Symbol: Stam2

Ensembl ID: ENSMUSG00000055371

Description: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Deubiquitination
(R-MMU-5688426)
Egfr downregulation
(R-MMU-182971)
Endosomal sorting complex required for transport (escrt)
(R-MMU-917729)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of met activity
(R-MMU-6807004)
Post-translational protein modification
(R-MMU-597592)
Rho gtpase cycle
(R-MMU-9012999)
Rhou gtpase cycle
(R-MMU-9013420)
Signaling by egfr
(R-MMU-177929)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Ub-specific processing proteases
(R-MMU-5689880)
Vesicle-mediated transport
(R-MMU-5653656)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytic vesicle
(GO:0030139)
Endosome
(GO:0005768)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Phosphatidylinositol binding
(GO:0035091)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Signal transduction
(GO:0007165)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Signal transducing adapter molecule 2

Genular Protein ID: 3321950507

Symbol: STAM2_MOUSE

Name: Signal transducing adapter molecule 2

UniProtKB Accession Codes:

O88811 A2AU00 Q8C8Y4

Database IDs:

Citations:

PubMed ID: 10651905

Title: A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors.

PubMed ID: 10651905

DOI: 10.1046/j.1365-2443.2000.00303.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10982817

Title: A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.

PubMed ID: 10982817

DOI: 10.1074/jbc.m007251200

PubMed ID: 12446783

Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.

PubMed ID: 12446783

DOI: 10.1128/mcb.22.24.8648-8658.2002

PubMed ID: 12551915

Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

PubMed ID: 12551915

DOI: 10.1074/jbc.m210843200

PubMed ID: 12972556

Title: STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.

PubMed ID: 12972556

DOI: 10.1091/mbc.e02-12-0823

PubMed ID: 16159959

Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

PubMed ID: 16159959

DOI: 10.1242/jcs.02571

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 13129930

Title: Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.

PubMed ID: 13129930

DOI: 10.1074/jbc.m306677200

Sequence Information:

Length: 523
Mass: 57455
Checksum: CE00B59F10BA0161
Sequence:

MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP SGAKDCLKAI MKRVNHKVPH 
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRSVIKNK AHPKVCEKLK SLMVEWSEEF 
QKDPQFSLIS ATIKSMKEEG VTFPSAGSQT VAAAAKNGTS LNKNKEDEDI AKAIELSLQE 
QKQQYTETKA LYPPAESQLN NKAARRVRAL YDFEAVEDNE LTFKHGELIT VLDDSDANWW 
QGENHRGTGL FPSNFVTTDL STEVETATVD KLNVIDDDVE EIKKSEPEPV YIDEGKMDRA 
LQILQSIDPK ESKPDSQDLL DLEDVCQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALDL 
YNKLVNEAPV YSVYSKLHPA HYPPAAAGVP VQTYPVQSHG GNYLGHGIHQ VSVAQNYNLG 
PDPMGSLRSL PPNMNSVTAH TVQPPYLSTG QDTVSNPSYM NQSSRLQAAA GTAAYTQPVG 
MSTDVSSFQN TASGLPQLAG FPVAVPAPVA AQPQASYHQQ PLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stam2

Associated with

Other Information

A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. PubMed ID: 10651905

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. PubMed ID: 10982817

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. PubMed ID: 12446783

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. PubMed ID: 12551915

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. PubMed ID: 12972556

Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. PubMed ID: 16159959

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. PubMed ID: 13129930