Details for: METTL3

Gene ID: 56339

Symbol: METTL3

Ensembl ID: ENSG00000165819

Description: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

Associated with

Other Information

Genular Protein ID: 2313327618

Symbol: MTA70_HUMAN

Name: N6-adenosine-methyltransferase 70 kDa subunit

UniProtKB Accession Codes:

Q86U44 O14736 Q86V05 Q9HB32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 70 PDBsum 60 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9409616

Title: Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.

PubMed ID: 9409616

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22575960

Title: Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

PubMed ID: 22575960

DOI: 10.1038/nature11112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24407421

Title: Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

PubMed ID: 24407421

DOI: 10.1038/cr.2014.3

PubMed ID: 24981863

Title: Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.

PubMed ID: 24981863

DOI: 10.1016/j.celrep.2014.05.048

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24284625

Title: N-methyladenosine-dependent regulation of messenger RNA stability.

PubMed ID: 24284625

DOI: 10.1038/nature12730

PubMed ID: 25719671

Title: N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.

PubMed ID: 25719671

DOI: 10.1038/nature14234

PubMed ID: 25799998

Title: N6-methyladenosine marks primary microRNAs for processing.

PubMed ID: 25799998

DOI: 10.1038/nature14281

PubMed ID: 26321680

Title: HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events.

PubMed ID: 26321680

DOI: 10.1016/j.cell.2015.08.011

PubMed ID: 26593424

Title: 5' UTR m(6)A promotes cap-independent translation.

PubMed ID: 26593424

DOI: 10.1016/j.cell.2015.10.012

PubMed ID: 26458103

Title: Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

PubMed ID: 26458103

DOI: 10.1038/nature15377

PubMed ID: 27117702

Title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.

PubMed ID: 27117702

DOI: 10.1016/j.molcel.2016.03.021

PubMed ID: 27602518

Title: m(6)A RNA methylation promotes XIST-mediated transcriptional repression.

PubMed ID: 27602518

DOI: 10.1038/nature19342

PubMed ID: 28637692

Title: m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.

PubMed ID: 28637692

DOI: 10.1101/gad.301036.117

PubMed ID: 28297716

Title: RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response.

PubMed ID: 28297716

DOI: 10.1038/nature21671

PubMed ID: 29507755

Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

PubMed ID: 29507755

DOI: 10.1038/s41421-018-0019-0

PubMed ID: 30428350

Title: Circadian clock regulation of hepatic lipid metabolism by modulation of m6A mRNA methylation.

PubMed ID: 30428350

DOI: 10.1016/j.celrep.2018.10.068

PubMed ID: 29506078

Title: SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

PubMed ID: 29506078

DOI: 10.1093/nar/gky156

PubMed ID: 29348140

Title: Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.

PubMed ID: 29348140

DOI: 10.1261/rna.064063.117

PubMed ID: 30559377

Title: m6A modification controls the innate immune response to infection by targeting type I interferons.

PubMed ID: 30559377

DOI: 10.1038/s41590-018-0275-z

PubMed ID: 33961823

Title: METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.

PubMed ID: 33961823

DOI: 10.1016/j.celrep.2021.109091

PubMed ID: 27627798

Title: Structural insights into the molecular mechanism of the m(6)A writer complex.

PubMed ID: 27627798

DOI: 10.7554/elife.18434

PubMed ID: 27373337

Title: Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases.

PubMed ID: 27373337

DOI: 10.1016/j.molcel.2016.05.041

PubMed ID: 27281194

Title: Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

PubMed ID: 27281194

DOI: 10.1038/nature18298

Sequence Information:

  • Length: 580
  • Mass: 64474
  • Checksum: 63A7F10195A3C6AC
  • Sequence:
    • MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG 
PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL 
QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA GTVTGQKRRA 
EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK 
KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR 
RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS QELALTQSVG 
GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP 
VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK 
EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV 
QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.