Details for: Mtch2

Gene ID: 56428

Symbol: Mtch2

Ensembl ID: ENSMUSG00000027282

Description: mitochondrial carrier 2

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cellular response to radiation
    (GO:0071478)
  • Establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
    (GO:0090152)
  • Hematopoietic stem cell homeostasis
    (GO:0061484)
  • Hematopoietic stem cell migration
    (GO:0035701)
  • Hepatocyte apoptotic process
    (GO:0097284)
  • Lactate metabolic process
    (GO:0006089)
  • Lipid homeostasis
    (GO:0055088)
  • Membrane
    (GO:0016020)
  • Membrane insertase activity
    (GO:0032977)
  • Mitochondrial atp synthesis coupled electron transport
    (GO:0042775)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of glycolytic process
    (GO:0045820)
  • Negative regulation of mitochondrial membrane potential
    (GO:0010917)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902231)
  • Positive regulation of stem cell differentiation
    (GO:2000738)
  • Protein binding
    (GO:0005515)
  • Protein insertion into mitochondrial outer membrane
    (GO:0045040)
  • Protein localization to mitochondrion
    (GO:0070585)
  • Regulation of mitochondrial fusion
    (GO:0010635)
  • Regulation of mitochondrial membrane permeability involved in apoptotic process
    (GO:1902108)

Other Information

Genular Protein ID: 3342143278

Symbol: MTCH2_MOUSE

Name: Mitochondrial carrier homolog 2

UniProtKB Accession Codes:

Q791V5 Q3TPS5 Q99LZ6 Q9D060 Q9D7Y2 Q9QZP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12407445

Title: Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization.

PubMed ID: 12407445

DOI: 10.1038/sj.neo.7900272

PubMed ID: 15899861

Title: Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.

PubMed ID: 15899861

DOI: 10.1128/mcb.25.11.4579-4590.2005

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20436477

Title: MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.

PubMed ID: 20436477

DOI: 10.1038/ncb2057

PubMed ID: 26219591

Title: An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate.

PubMed ID: 26219591

DOI: 10.1038/ncomms8901

PubMed ID: 26876167

Title: Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.

PubMed ID: 26876167

DOI: 10.1016/j.celrep.2016.01.046

PubMed ID: 28127879

Title: MTCH2 is a conserved regulator of lipid homeostasis.

PubMed ID: 28127879

DOI: 10.1002/oby.21751

PubMed ID: 30510213

Title: MTCH2-mediated mitochondrial fusion drives exit from naive pluripotency in embryonic stem cells.

PubMed ID: 30510213

DOI: 10.1038/s41467-018-07519-w

Sequence Information:

  • Length: 303
  • Mass: 33499
  • Checksum: 248F8A1E4CF29975
  • Sequence:
    • MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFCYAQH 
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQYYQESEK PEELGSVTVQ KEYSSSFDRV 
IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIVTIY REEGIVGFFA 
GLIPRLLGDI ISLWLCNSLA YLINTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV 
SNLMAVNNCG LAGGSPPYSP IYTSWIDCWC MLQKAGNMSR GNSLFFRKVP CGKTYCYDLR 
MLI

Genular Protein ID: 3399835181

Symbol: A2AFW6_MOUSE

Name: N/A

UniProtKB Accession Codes:

A2AFW6

Database IDs:

AGR 1 ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 2 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 SwissPalm 1 TopDownProteomics 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 294
  • Mass: 32345
  • Checksum: C544178B672FB633
  • Sequence:
    • MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFCYAQH 
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQELGSVTV QKEYSSSFDR VIKETTREMI 
ARSAATLITH PFHVITLRSM VQFIGRESKY CGLCDSIVTI YREEGIVGFF AGLIPRLLGD 
IISLWLCNSL AYLINTYALD SGVSTMNEMK SYSQAVTGFF ASMLTYPFVL VSNLMAVNNC 
GLAGGSPPYS PIYTSWIDCW CMLQKAGNMS RGNSLFFRKV PCGKTYCYDL RMLI

Genular Protein ID: 2805258918

Symbol: Q9D050_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9D050

Database IDs:

AGR 1 ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 InterPro 2 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SUPFAM 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 312
  • Mass: 34554
  • Checksum: 74D01F3178CF10C9
  • Sequence:
    • MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFCYAQH 
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQYYQESEK PEISVFAFDF QELGSVTVQK 
EYSSSFDRVI KETTREMIAR SAATLITHPF HVITLRSMVQ FIGRESKYCG LCDSIVTIYR 
EEGIVGFFAG LIPRLLGDII SLWLCNSLAY LINTYALDSG VSTMNEMKSY SQAVTGFFAS 
MLTYPFVLVS NLMAVNNCGL AGGSPPYSPI YTSWIDCWCM LQKAGNMSRG NSLFFRKVPC 
GKTYCYDLRM LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.