Rbx1 | ENSMUSG00000022400 | NCBI 56438

Details for: Rbx1

Gene ID: 56438

Symbol: Rbx1

Ensembl ID: ENSMUSG00000022400

Description: ring-box 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cytokine signaling in immune system
(R-MMU-1280215)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of dvl
(R-MMU-4641258)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Dna damage bypass
(R-MMU-73893)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dna replication
(R-MMU-69306)
Dual incision in gg-ner
(R-MMU-5696400)
Dual incision in tc-ner
(R-MMU-6782135)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-MMU-8854050)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Formation of tc-ner pre-incision complex
(R-MMU-6781823)
G2/m transition
(R-MMU-69275)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-MMU-9762114)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Immune system
(R-MMU-168256)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
Mitotic g2-g2/m phases
(R-MMU-453274)
Neddylation
(R-MMU-8951664)
Nuclear events mediated by nfe2l2
(R-MMU-9759194)
Nucleotide excision repair
(R-MMU-5696398)
Orc1 removal from chromatin
(R-MMU-68949)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Post-translational protein modification
(R-MMU-597592)
Prolactin receptor signaling
(R-MMU-1170546)
Raf/map kinase cascade
(R-MMU-5673001)
Recognition of dna damage by pcna-containing replication complex
(R-MMU-110314)
Regulation of bach1 activity
(R-MMU-9708530)
Regulation of ras by gaps
(R-MMU-5658442)
Regulation of runx2 expression and activity
(R-MMU-8939902)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Transcriptional regulation by runx2
(R-MMU-8878166)
Cellular response to uv
(GO:0034644)
Cullin family protein binding
(GO:0097602)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Eukaryotic initiation factor 4e binding
(GO:0008190)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Nedd8 ligase activity
(GO:0061663)
Negative regulation of type i interferon production
(GO:0032480)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein monoubiquitination
(GO:0006513)
Protein neddylation
(GO:0045116)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Spermatogenesis
(GO:0007283)
T cell activation
(GO:0042110)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase RBX1

Genular Protein ID: 2264247958

Symbol: RBX1_MOUSE

Name: E3 ubiquitin-protein ligase RBX1

UniProtKB Accession Codes:

P62878 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254

Database IDs:

Citations:

PubMed ID: 10213691

Title: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

PubMed ID: 10213691

DOI: 10.1126/science.284.5414.657

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10643962

Title: Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1.

PubMed ID: 10643962

PubMed ID: 11384984

Title: Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

PubMed ID: 11384984

DOI: 10.1074/jbc.m103093200

PubMed ID: 12140560

Title: E3 ubiquitin ligase that recognizes sugar chains.

PubMed ID: 12140560

DOI: 10.1038/nature00890

PubMed ID: 24357321

Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

PubMed ID: 24357321

DOI: 10.1126/science.1244587

PubMed ID: 33590678

Title: CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.

PubMed ID: 33590678

DOI: 10.15252/embr.202052164

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

Sequence Information:

Length: 108
Mass: 12274
Checksum: 30FC5ADF66096C0E
Sequence:

MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ 
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rbx1

Associated with

Other Information

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. PubMed ID: 10213691

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1. PubMed ID: 10643962

Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. PubMed ID: 11384984

E3 ubiquitin ligase that recognizes sugar chains. PubMed ID: 12140560

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. PubMed ID: 24357321

CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. PubMed ID: 33590678

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. PubMed ID: 22118460