Details for: Foxo1
Associated with
Other Information
Genular Protein ID: 2420227832
Symbol: FOXO1_MOUSE
Name: Forkhead box protein O1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10347145
Title: Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.
PubMed ID: 10347145
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 12219087
Title: Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
PubMed ID: 12219087
DOI: 10.1038/ng890
PubMed ID: 12754525
Title: Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
PubMed ID: 12754525
DOI: 10.1038/nature01667
PubMed ID: 15184386
Title: Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.
PubMed ID: 15184386
PubMed ID: 15220471
Title: Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
PubMed ID: 15220471
PubMed ID: 16076959
Title: Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
PubMed ID: 16076959
PubMed ID: 17050673
Title: Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
PubMed ID: 17050673
DOI: 10.1101/gad.1483906
PubMed ID: 17090532
Title: SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
PubMed ID: 17090532
PubMed ID: 16917544
Title: The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.
PubMed ID: 16917544
DOI: 10.1172/jci25518
PubMed ID: 17681146
Title: SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
PubMed ID: 17681146
PubMed ID: 17627282
Title: Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.
PubMed ID: 17627282
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 18388859
Title: Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
PubMed ID: 18388859
PubMed ID: 18951090
Title: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
PubMed ID: 18951090
PubMed ID: 19037106
Title: SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.
PubMed ID: 19037106
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20061393
Title: Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.
PubMed ID: 20061393
PubMed ID: 20519497
Title: Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization.
PubMed ID: 20519497
PubMed ID: 19965929
Title: Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1.
PubMed ID: 19965929
DOI: 10.1210/me.2009-0265
PubMed ID: 20668652
Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
PubMed ID: 20668652
PubMed ID: 21196578
Title: FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.
PubMed ID: 21196578
PubMed ID: 21335550
Title: Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).
PubMed ID: 21335550
PubMed ID: 21471200
Title: Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts.
PubMed ID: 21471200
PubMed ID: 21317886
Title: Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
PubMed ID: 21317886
DOI: 10.1038/nm.2293
PubMed ID: 22417654
Title: The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress.
PubMed ID: 22417654
DOI: 10.1042/bj20111606
PubMed ID: 22510882
Title: Novel repressor regulates insulin sensitivity through interaction with Foxo1.
PubMed ID: 22510882
PubMed ID: 22298775
Title: FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.
PubMed ID: 22298775
PubMed ID: 25009184
Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
PubMed ID: 25009184
PubMed ID: 27827363
Title: Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.
PubMed ID: 27827363
DOI: 10.1038/ncomms13267
PubMed ID: 27457971
Title: Insulin secretion impairment in Sirt6 knockout pancreatic beta cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway.
PubMed ID: 27457971
DOI: 10.1038/srep30321
PubMed ID: 28790135
Title: DDB1-mediated CRY1 degradation promotes FOXO1-driven gluconeogenesis in liver.
PubMed ID: 28790135
DOI: 10.2337/db16-1600
PubMed ID: 31442424
Title: Non-canonical mTORC2 signaling regulates brown adipocyte lipid catabolism through SIRT6-FoxO1.
PubMed ID: 31442424
PubMed ID: 32103177
Title: Lipid availability determines fate of skeletal progenitor cells via SOX9.
PubMed ID: 32103177
PubMed ID: 34914893
Title: TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
PubMed ID: 34914893
Sequence Information:
- Length: 652
- Mass: 69518
- Checksum: 3FF58636EA85205F
- Sequence:
MAEAPQVVET DPDFEPLPRQ RSCTWPLPRP EFNQSNSTTS SPAPSGGAAA NPDAAASLAS ASAVSTDFMS NLSLLEESED FARAPGCVAV AAAAAASRGL CGDFQGPEAG CVHPAPPQPP PTGPLSQPPP VPPSAAAAAG PLAGQPRKTS SSRRNAWGNL SYADLITKAI ESSAEKRLTL SQIYEWMVKS VPYFKDKGDS NSSAGWKNSI RHNLSLHSKF IRVQNEGTGK SSWWMLNPEG GKSGKSPRRR AASMDNNSKF AKSRGRAAKK KASLQSGQEG PGDSPGSQFS KWPASPGSHS NDDFDNWSTF RPRTSSNAST ISGRLSPIMT EQDDLGDGDV HSLVYPPSAA KMASTLPSLS EISNPENMEN LLDNLNLLSS PTSLTVSTQS SPGSMMQQTP CYSFAPPNTS LNSPSPNYSK YTYGQSSMSP LPQMPMQTLQ DSKSSYGGLN QYNCAPGLLK ELLTSDSPPH NDIMSPVDPG VAQPNSRVLG QNVMMGPNSV MPAYGSQASH NKMMNPSSHT HPGHAQQTAS VNGRTLPHVV NTMPHTSAMN RLTPVKTPLQ VPLSHPMQMS ALGSYSSVSS CNGYGRMGVL HQEKLPSDLD GMFIERLDCD MESIIRNDLM DGDTLDFNFD NVLPNQSFPH SVKTTTHSWV SG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.