Details for: Socs5

Gene ID: 56468

Symbol: Socs5

Ensembl ID: ENSMUSG00000037104

Description: suppressor of cytokine signaling 5

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-MMU-6785807)
  • Metabolism of proteins
    (R-MMU-392499)
  • Neddylation
    (R-MMU-8951664)
  • Post-translational protein modification
    (R-MMU-597592)
  • Signaling by interleukins
    (R-MMU-449147)
  • 1-phosphatidylinositol-3-kinase regulator activity
    (GO:0046935)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasm
    (GO:0005737)
  • Epidermal growth factor receptor binding
    (GO:0005154)
  • Epidermal growth factor receptor signaling pathway
    (GO:0007173)
  • Intracellular signal transduction
    (GO:0035556)
  • Kinase inhibitor activity
    (GO:0019210)
  • Negative regulation of endothelial cell activation
    (GO:1904988)
  • Negative regulation of epidermal growth factor-activated receptor activity
    (GO:0007175)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of monocyte chemotactic protein-1 production
    (GO:0071638)
  • Negative regulation of signal transduction
    (GO:0009968)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Phosphatidylinositol 3-kinase complex
    (GO:0005942)
  • Phosphatidylinositol phosphate biosynthetic process
    (GO:0046854)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of t-helper 1 cell differentiation
    (GO:0045627)
  • Protein binding
    (GO:0005515)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Vascular endothelial cell response to fluid shear stress
    (GO:0097699)

Other Information

Genular Protein ID: 1409578553

Symbol: SOCS5_MOUSE

Name: Suppressor of cytokine signaling 5

UniProtKB Accession Codes:

O54928 Q7TSK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisProt 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9419338

Title: Twenty proteins containing a C-terminal SOCS box form five structural classes.

PubMed ID: 9419338

DOI: 10.1073/pnas.95.1.114

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12242343

Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.

PubMed ID: 12242343

DOI: 10.1073/pnas.202477099

Sequence Information:

  • Length: 536
  • Mass: 61086
  • Checksum: B63AD64BC8CEE254
  • Sequence:
    • MDKVGKMWNN LKYRCQNLFS HEGGSRNENV EMNPNRCPSV KEKSISLGEA APQQESSPLR 
ENVALQLGLS PSKTFSRRNQ NCAAEIPQVV EISIEKDSDS GATPGTRLAR RDSYSRHAPW 
GGKKKHSCST KTQSSLDTEK KFGRTRSGLQ RRERRYGVSS MQDMDSVSSR AVGSRSLRQR 
LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV 
SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG 
PKLAPGMTEI SGDGSAIPQT NCDSEEDSTT LCLQSRRQKQ RQVSGDSHAH VSRQGAWKVH 
TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR 
RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF 
PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.