Pias1 | ENSMUSG00000032405 | NCBI 56469

Details for: Pias1

Gene ID: 56469

Symbol: Pias1

Ensembl ID: ENSMUSG00000032405

Description: protein inhibitor of activated STAT 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Dna repair
(R-MMU-73894)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Immune system
(R-MMU-168256)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Metabolism of proteins
(R-MMU-392499)
Nucleotide excision repair
(R-MMU-5696398)
Post-translational protein modification
(R-MMU-597592)
Regulation of ifng signaling
(R-MMU-877312)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of chromatin organization proteins
(R-MMU-4551638)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Sumoylation of transcription factors
(R-MMU-3232118)
Sumoylation of ubiquitinylation proteins
(R-MMU-3232142)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear periphery
(GO:0034399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein localization to cell periphery
(GO:1904377)
Positive regulation of protein sumoylation
(GO:0033235)
Positive regulation of smooth muscle cell differentiation
(GO:0051152)
Protein-dna complex assembly
(GO:0065004)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein sumoylation
(GO:0016925)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sumo ligase activity
(GO:0061665)
Sumo transferase activity
(GO:0019789)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)
Visual learning
(GO:0008542)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 SUMO-protein ligase PIAS1

Genular Protein ID: 486540827

Symbol: PIAS1_MOUSE

Name: E3 SUMO-protein ligase PIAS1

UniProtKB Accession Codes:

O88907 Q8C6H5

Database IDs:

Citations:

PubMed ID: 9724754

Title: Inhibition of Stat1-mediated gene activation by PIAS1.

PubMed ID: 9724754

DOI: 10.1073/pnas.95.18.10626

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10854042

Title: Cloning and analysis of a murine Pias family member, Pias-gamma, in developing skin and neurons.

PubMed ID: 10854042

DOI: 10.1385/jmn:14:1-2:107

PubMed ID: 11117529

Title: ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.

PubMed ID: 11117529

DOI: 10.1210/mend.14.12.0569

PubMed ID: 12077349

Title: PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.

PubMed ID: 12077349

DOI: 10.1128/mcb.22.14.5222-5234.2002

PubMed ID: 12855578

Title: PIAS proteins promote SUMO-1 conjugation to STAT1.

PubMed ID: 12855578

DOI: 10.1182/blood-2002-12-3816

PubMed ID: 16600910

Title: PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

PubMed ID: 16600910

DOI: 10.1101/gad.1392006

PubMed ID: 17938210

Title: Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis.

PubMed ID: 17938210

DOI: 10.1128/mcb.00589-07

PubMed ID: 17187077

Title: SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.

PubMed ID: 17187077

DOI: 10.1038/nsmb1185

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22406621

Title: The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

PubMed ID: 22406621

DOI: 10.1158/0008-5472.can-11-3159

PubMed ID: 24061474

Title: Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta) during adipogenesis.

PubMed ID: 24061474

DOI: 10.1128/mcb.00723-13

Sequence Information:

Length: 651
Mass: 71618
Checksum: 8844364E8FEE4F7F
Sequence:

MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL 
YRRRFPQKIM TPADLSIPNV HSSPMPPTLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL 
ELPHLTSALH PVHPDIKLQK LPFYDLLDEL IKPTSLASDN SQRFRETCFA FALTPQQVQQ 
ISSSMDISGT KCDFTVQVQL RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG 
VEPKRPSRPI NITSLVRLST TVPNTIVVSW TAEIGRTYSM AVYLVKQLSS TVLLQRLRAK 
GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT CSHLQCFDAT 
LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT DCDEIQFKED GSWAPMRSKK 
EVQEVTASYN GVDGCLSSTL EHQVASHNQS SNKNKKVEVI DLTIDSSSDE EEEEPPAKRT 
CPSLSPTSPL SNKGILSLPH QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL 
QGLDFFPFLS GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS 
LPATNGSSSG SNSSLVSSNS LRESHGHGVA SRSSADTASI FGIIPDIISL D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pias1

Associated with

Other Information

Inhibition of Stat1-mediated gene activation by PIAS1. PubMed ID: 9724754

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and analysis of a murine Pias family member, Pias-gamma, in developing skin and neurons. PubMed ID: 10854042

ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. PubMed ID: 11117529

PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. PubMed ID: 12077349

PIAS proteins promote SUMO-1 conjugation to STAT1. PubMed ID: 12855578

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. PubMed ID: 16600910

Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. PubMed ID: 17938210

SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. PubMed ID: 17187077

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. PubMed ID: 22406621

Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta) during adipogenesis. PubMed ID: 24061474