Details for: EIF4ENIF1
Associated with
Other Information
Genular Protein ID: 589355191
Symbol: 4ET_HUMAN
Name: Eukaryotic translation initiation factor 4E nuclear import factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10856257
Title: A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.
PubMed ID: 10856257
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16157702
Title: A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
PubMed ID: 16157702
PubMed ID: 16699599
Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.
PubMed ID: 16699599
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22090346
Title: RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor.
PubMed ID: 22090346
PubMed ID: 22966201
Title: Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.
PubMed ID: 22966201
DOI: 10.1128/mcb.00544-12
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23991149
Title: Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.
PubMed ID: 23991149
PubMed ID: 24335285
Title: Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.
PubMed ID: 24335285
DOI: 10.1093/nar/gkt1265
PubMed ID: 26027925
Title: The eIF4E-Binding protein 4E-T is a component of the mRNA decay machinery that bridges the 5' and 3' termini of target mRNAs.
PubMed ID: 26027925
PubMed ID: 25923732
Title: Phosphorylation of eIF4E confers resistance to cellular stress and DNA-damaging agents through an interaction with 4E-T: a rationale for novel therapeutic approaches.
PubMed ID: 25923732
PubMed ID: 27342281
Title: The DDX6-4E-T interaction mediates translational repression and P-body assembly.
PubMed ID: 27342281
DOI: 10.1093/nar/gkw565
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28487484
Title: Cap-binding protein 4EHP effects translation silencing by microRNAs.
PubMed ID: 28487484
PubMed ID: 28216671
Title: Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6.
PubMed ID: 28216671
DOI: 10.1038/srep42853
PubMed ID: 31422817
Title: Rare de novo missense variants in RNA helicase DDX6 cause intellectual disability and dysmorphic features and lead to P-body defects and RNA dysregulation.
PubMed ID: 31422817
PubMed ID: 31439631
Title: Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.
PubMed ID: 31439631
PubMed ID: 32354837
Title: 4E-T-bound mRNAs are stored in a silenced and deadenylated form.
PubMed ID: 32354837
PubMed ID: 26489469
Title: Structure of a human 4E-T/DDX6/CNOT1 complex reveals the different interplay of DDX6-binding proteins with the CCR4-NOT complex.
PubMed ID: 26489469
PubMed ID: 29510985
Title: Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
PubMed ID: 29510985
Sequence Information:
- Length: 985
- Mass: 108201
- Checksum: 4C898E0488903C04
- Sequence:
MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC LSEKYDSDGV WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD PRERVKEDDL DVVLSPQRRS FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL GGRRIGSGRI ISARTFEKDH RLSDKDLRDL RDRDRERDFK DKRFRREFGD SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD KILEEDHKGR KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR SSSLGSTPHE ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE MLQKAKVDLK PLLSSLSANK EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ VKNSTPFMAE HLEETLSAVT NNRQLKKDGD MTAFNKLVST MKASGTLPSQ PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS SNLLSGLMGS LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK PQVDRTRDGF RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS VIRKMYESKE KSKEEPASGK AALGDSKEDT QKASEENLLS SSSVPSADRD SSPTTNSKLS ALQRSSCSTP LSQANRYTKE QDYRPKATGR KTPTLASPVP TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH PQHLPSLLQT GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS SPVGLAKWFG SDVLQQPLPS MPAKVISVDE LEYRQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.