Tbk1 | ENSMUSG00000020115 | NCBI 56480

Details for: Tbk1

Gene ID: 56480

Symbol: Tbk1

Ensembl ID: ENSMUSG00000020115

Description: TANK-binding kinase 1

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-37 signaling
(R-MMU-9008059)
Irf3-mediated induction of type i ifn
(R-MMU-3270619)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Negative regulators of ddx58/ifih1 signaling
(R-MMU-936440)
Regulation of innate immune responses to cytosolic dna
(R-MMU-3134975)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Stat6-mediated induction of chemokines
(R-MMU-3249367)
Sting mediated induction of host immune responses
(R-MMU-1834941)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Activation of innate immune response
(GO:0002218)
Antiviral innate immune response
(GO:0140374)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to virus
(GO:0051607)
Dendritic cell proliferation
(GO:0044565)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Interferon-beta production
(GO:0032608)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase activity
(GO:0016301)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of torc1 signaling
(GO:1904262)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphoprotein binding
(GO:0051219)
Phosphorylation
(GO:0016310)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Positive regulation of type i interferon production
(GO:0032481)
Positive regulation of xenophagy
(GO:1904417)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cellular metabolic process
(GO:0031323)
Regulation of gene expression
(GO:0010468)
Regulation of type i interferon production
(GO:0032479)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Transferase activity
(GO:0016740)

Other Information

Proteins

TBK1_MOUSE

Genular Protein ID: 1872561208

Symbol: TBK1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9WUN2 Q9CT90 Q9DC03

Database IDs:

Citations:

PubMed ID: 10581243

Title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.

PubMed ID: 10581243

DOI: 10.1093/emboj/18.23.6694

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10990461

Title: Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.

PubMed ID: 10990461

DOI: 10.1093/emboj/19.18.4976

PubMed ID: 15210742

Title: The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

PubMed ID: 15210742

DOI: 10.1084/jem.20040520

PubMed ID: 14679297

Title: IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.

PubMed ID: 14679297

DOI: 10.1073/pnas.2237236100

PubMed ID: 15661922

Title: Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1.

PubMed ID: 15661922

DOI: 10.4049/jimmunol.174.3.1602

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23396211

Title: An inhibitor of the protein kinases TBK1 and IKK-[?] improves obesity-related metabolic dysfunctions in mice.

PubMed ID: 23396211

DOI: 10.1038/nm.3082

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 23746807

Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.

PubMed ID: 23746807

DOI: 10.1016/j.str.2013.04.025

Sequence Information:

Length: 729
Mass: 83425
Checksum: 978ADDE3061DACD1
Sequence:

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLYAVKVF NNISFLRPVD VQMREFEVLK 
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 
GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 
HPDMYERAVL RKDHQKKYGA TVDLWSVGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG 
KPSGAISGVQ KAENGPIDWS GDMPLSCSLS QGLQALLTPV LANILEADQE KCWGFDQFFA 
ETSDVLHRMV IHVFSLQHMT AHKIYIHSYN TAAVFHELVY KQTKIVSSNQ ELIYEGRRLV 
LELGRLAQHF PKTTEENPIF VTSREQLNTV GLRYEKISLP KIHPRYDLDG DASMAKAVTG 
VVCYACRTAS TLLLYQELMR KGVRWLVELV KDDYNETVHK KTEVVITLDF CIRNIEKTVK 
VYEKLMKVNL EAAELGEISD IHTKLLRLSS SQGTIESSLQ DISSRLSPGG LLADTWAHQE 
GTHPRDRNVE KLQVLLNCIT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMSH 
FSEECVRKYE AFKDKSEEWM RKMLHLRKQL LSLTNQCFDI EEEVSKYQDY TNELQETLPQ 
KMLAASGGVK HAMAPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD 
GGLRNVDCL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tbk1

Associated with

Other Information

NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. PubMed ID: 10581243

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. PubMed ID: 10990461

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. PubMed ID: 15210742

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. PubMed ID: 14679297

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. PubMed ID: 15661922

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

An inhibitor of the protein kinases TBK1 and IKK-[?] improves obesity-related metabolic dysfunctions in mice. PubMed ID: 23396211

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. PubMed ID: 31320558

Structural insights into the functions of TBK1 in innate antimicrobial immunity. PubMed ID: 23746807