Foxo3 | ENSMUSG00000048756 | NCBI 56484

Details for: Foxo3

Gene ID: 56484

Symbol: Foxo3

Ensembl ID: ENSMUSG00000048756

Description: forkhead box O3

Associated with

Akt phosphorylates targets in the nucleus
(R-MMU-198693)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-MMU-9634638)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Flt3 signaling
(R-MMU-9607240)
Foxo-mediated transcription
(R-MMU-9614085)
Foxo-mediated transcription of cell cycle genes
(R-MMU-9617828)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Pip3 activates akt signaling
(R-MMU-1257604)
Regulation of foxo transcriptional activity by acetylation
(R-MMU-9617629)
Regulation of localization of foxo transcription factors
(R-MMU-9614399)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nodal
(R-MMU-1181150)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Antral ovarian follicle growth
(GO:0001547)
Apoptotic process
(GO:0006915)
Beta-catenin binding
(GO:0008013)
Brain morphogenesis
(GO:0048854)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to oxidative stress
(GO:0034599)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Glucose homeostasis
(GO:0042593)
Initiation of primordial ovarian follicle growth
(GO:0001544)
Membrane
(GO:0016020)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial transcription
(GO:0006390)
Mitochondrial transcription factor activity
(GO:0034246)
Mitochondrion
(GO:0005739)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Ovulation from ovarian follicle
(GO:0001542)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of hydrogen peroxide-mediated programmed cell death
(GO:1901300)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of muscle atrophy
(GO:0014737)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to fatty acid
(GO:0070542)
Response to starvation
(GO:0042594)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription repressor complex
(GO:0090571)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)

Other Information

Proteins

FOXO3_MOUSE

Genular Protein ID: 3096608951

Symbol: FOXO3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9WVH4 D3Z6Y6 Q05CZ4

Database IDs:

Citations:

PubMed ID: 11353388

Title: Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.

PubMed ID: 11353388

DOI: 10.1007/s003350020002

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17521387

Title: SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

PubMed ID: 17521387

DOI: 10.1111/j.1474-9726.2007.00304.x

PubMed ID: 18054316

Title: FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

PubMed ID: 18054316

DOI: 10.1016/j.cmet.2007.11.004

PubMed ID: 18054315

Title: FoxO3 controls autophagy in skeletal muscle in vivo.

PubMed ID: 18054315

DOI: 10.1016/j.cmet.2007.11.001

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22510882

Title: Novel repressor regulates insulin sensitivity through interaction with Foxo1.

PubMed ID: 22510882

DOI: 10.1038/emboj.2012.97

PubMed ID: 23283301

Title: A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

PubMed ID: 23283301

DOI: 10.1007/s00018-012-1244-6

PubMed ID: 23805378

Title: CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.

PubMed ID: 23805378

DOI: 10.7554/elife.00518

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25402684

Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.

PubMed ID: 25402684

DOI: 10.1038/ncb3062

PubMed ID: 29445193

Title: Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

PubMed ID: 29445193

DOI: 10.1038/s41419-018-0336-0

PubMed ID: 32103177

Title: Lipid availability determines fate of skeletal progenitor cells via SOX9.

PubMed ID: 32103177

DOI: 10.1038/s41586-020-2050-1

Sequence Information:

Length: 672
Mass: 71064
Checksum: EC218D9BA0C1DAC5
Sequence:

MAEAPASPVP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE 
DDDEDDEDGG GRASSAMVIG GGVSSTLGSG LLLEDSAMLL APGGQDLGSG PASAAGALSG 
GTPTQLQPQQ PLPQPQPGAA GGSGQPRKCS SRRNAWGNLS YADLITRAIE SSPDKRLTLS 
QIYEWMVRCV PYFKDKGDSN SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG 
KSGKAPRRRA VSMDNSNKYT KSRGRAAKKK AALQAAPESA DDSPSQLSKW PGSPTSRSSD 
ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDG PLSPMLYSSS ASLSPSVSKP 
CTVELPRLTD MAGTMNLNDG LAENLMDDLL DNIALPPSQP SPPGGLMQRG SSFPYTAKSS 
GLGSPTGSFN STVFGPSSLN SLRQSPMQTI QENRPATFSS VSHYGNQTLQ DLLASDSLSH 
SDVMMTQSDP LMSQASTAVS AQNARRNVML RNDPMMSFAA QPTQGSLVNQ NLLHHQHQTQ 
GALGGSRALS NSVSNMGLSD SSSLGSAKHQ QQSPASQSMQ TLSDSLSGSS LYSASANLPV 
MGHDKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV VGLNVGNFTG 
AKQASSQSWV PG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Foxo3

Associated with

Other Information

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. PubMed ID: 11353388

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. PubMed ID: 17521387

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. PubMed ID: 18054316

FoxO3 controls autophagy in skeletal muscle in vivo. PubMed ID: 18054315

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Novel repressor regulates insulin sensitivity through interaction with Foxo1. PubMed ID: 22510882

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. PubMed ID: 23283301

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. PubMed ID: 23805378

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. PubMed ID: 25402684

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. PubMed ID: 29445193

Lipid availability determines fate of skeletal progenitor cells via SOX9. PubMed ID: 32103177