Ikbke | ENSMUSG00000042349 | NCBI 56489

Details for: Ikbke

Gene ID: 56489

Symbol: Ikbke

Ensembl ID: ENSMUSG00000042349

Description: inhibitor of kappaB kinase epsilon

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Negative regulators of ddx58/ifih1 signaling
(R-MMU-936440)
Post-translational protein modification
(R-MMU-597592)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of immune response proteins
(R-MMU-4755510)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Atp binding
(GO:0005524)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Ikappab kinase activity
(GO:0008384)
Immune response
(GO:0006955)
Interleukin-17-mediated signaling pathway
(GO:0097400)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
K48-linked polyubiquitin modification-dependent protein binding
(GO:0036435)
Kinase activity
(GO:0016301)
Mitochondrial membrane
(GO:0031966)
Mrna stabilization
(GO:0048255)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Pml body
(GO:0016605)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of lipid storage
(GO:0010884)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of protein-containing complex assembly
(GO:0043254)
Response to interferon-beta
(GO:0035456)
Response to type i interferon
(GO:0034340)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Genular Protein ID: 2132105643

Symbol: IKKE_MOUSE

Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

UniProtKB Accession Codes:

Q9R0T8 Q8C2I3

Database IDs:

Citations:

PubMed ID: 10421793

Title: IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.

PubMed ID: 10421793

DOI: 10.1093/intimm/11.8.1357

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15210742

Title: The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

PubMed ID: 15210742

DOI: 10.1084/jem.20040520

PubMed ID: 17568778

Title: SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.

PubMed ID: 17568778

DOI: 10.1038/sj.emboj.7601743

PubMed ID: 17332413

Title: Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.

PubMed ID: 17332413

DOI: 10.1126/science.1136567

PubMed ID: 19737522

Title: The protein kinase IKKepsilon regulates energy balance in obese mice.

PubMed ID: 19737522

DOI: 10.1016/j.cell.2009.06.046

PubMed ID: 22065572

Title: Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

PubMed ID: 22065572

DOI: 10.1074/jbc.m111.285205

PubMed ID: 22171011

Title: IkappaB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses.

PubMed ID: 22171011

DOI: 10.1073/pnas.1119137109

PubMed ID: 23396211

Title: An inhibitor of the protein kinases TBK1 and IKK-[?] improves obesity-related metabolic dysfunctions in mice.

PubMed ID: 23396211

DOI: 10.1038/nm.3082

Sequence Information:

Length: 717
Mass: 80953
Checksum: 0863ECC180AE385A
Sequence:

MQSTTNYLWH TDDLLGQGAT ASVYKARNKK SGEVVAVKVF NSASYRRPPE VQVREFEVLR 
RLNHQNIVKL FAVEETGGSR QKVLIMEYCS SGSLLSVLED PENTFGLSEE EFLVVLRCVV 
AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLSDFGA ARKLDDDEKF VSVYGTEEYL 
HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE 
KPAGAISGTQ KQENGPLEWS YSLPITCRLS MGLQNQLVPI LANILEVEED KCWGFDQFFA 
ETSDILQRTV IHVFSLPQAV LHHVYIHAHN TIAIFLEAVY EQTNVTPKHQ EYLFEGHPCV 
LEPSLSAQHI AHTAASSPLT LFSMSSDTPK GLAFRDPALD VPKFVPKVDL QADYSTAKGV 
LGAGYQALWL ARVLLDGQAL MLRGLHWVLE VLQDTCQQTL EVTRTALLYL SSSLGTERFS 
SGAGMPDVQE RKEATELRTR LQTLSEILSK CSHNVTETQR SLSCLGEELL KNRDQIHEDN 
KSIQKIQCCL DKMHFIYKQF KKSRMRPGLS YNEEQIHKLD KVNFSHLAKR LLQVFQEECV 
QTYQVSLVTH GKRMRQVQRA QNHLHLIGHS VATCNSEARG AQESLNKIFD QLLLDRASEQ 
GAEVSPQPMA PHPGPDPKDL VFHMQELCND MKLLAFDLQD NNRLIERLHR VPSAPDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ikbke

Associated with

Other Information

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. PubMed ID: 10421793

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. PubMed ID: 15210742

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. PubMed ID: 17568778

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. PubMed ID: 17332413

The protein kinase IKKepsilon regulates energy balance in obese mice. PubMed ID: 19737522

Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. PubMed ID: 22065572

IkappaB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. PubMed ID: 22171011

An inhibitor of the protein kinases TBK1 and IKK-[?] improves obesity-related metabolic dysfunctions in mice. PubMed ID: 23396211