Details for: Elf4

Gene ID: 56501

Symbol: Elf4

Ensembl ID: ENSMUSG00000031103

Description: E74 like ETS transcription factor 4

Associated with

  • Cell differentiation
    (GO:0030154)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Natural killer cell proliferation
    (GO:0001787)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nk t cell proliferation
    (GO:0001866)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pml body
    (GO:0016605)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 2814490870

Symbol: ELF4_MOUSE

Name: ETS-related transcription factor Elf-4

UniProtKB Accession Codes:

Q9Z2U4 B1AY67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 12387738

Title: The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells.

PubMed ID: 12387738

DOI: 10.1016/s1074-7613(02)00422-3

PubMed ID: 19380490

Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.

PubMed ID: 19380490

DOI: 10.1128/mcb.01551-08

PubMed ID: 19412182

Title: Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2.

PubMed ID: 19412182

DOI: 10.1038/ni.1730

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 34326534

Title: Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.

PubMed ID: 34326534

DOI: 10.1038/s41590-021-00984-4

PubMed ID: 35266071

Title: Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.

PubMed ID: 35266071

DOI: 10.1007/s10875-022-01243-3

Sequence Information:

  • Length: 655
  • Mass: 70800
  • Checksum: 44CAFA1D3D77153C
  • Sequence:
    • MAIALQPSDL VFEFASNGMD DIHQLEDPSV FPAVIVEQVP YPELVHLCSG LDLDEVHNGI 
IRDRTLCMTQ DQILEGSILL TDDDVSTSNN VSSTEVLFNV ATPSDVLDEK QIFSSPEVLS 
DSNSVQAINL PNFLLSTPEP DDLKKTSDAG DQKEHSEEEK VSREENLRKM GKARKRNRKT 
KNNRSTSPVT DPSMPIRKKS KDGKGSTIYL WEFLLALLQD RNTCPKYIKW TQREKGIFKL 
VDSKAVSKLW GKQKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLVVID 
DEEESPETPE DSSQASTSST PSTSTIRRAS SRVGTRASPE DKDNPPWEKP KVQHTGLQPS 
ASLELGLSVD EEVPTTSTML ASPLQSQARL TKTVSSSPAP SNIHLGVAPV GPGSTVTLQT 
IPLTTVLTNG PPASTTAPTQ LVLQSVPQVS TFKDTFTLQT SFPLNTNLQE NQVATQGAPL 
ILSGLPQLLA GANPQSNPAP SQVIGAGSAG PSSQPPGTVI AAFIRTSSGT SVPVVKEGPL 
RSSSYVQGVV TGAPVEGLLV PEETLRELLR DQGHLQPLPS QVLSRGSHNL SLVGNQTLSP 
PSHPTVGLTP VAELELSSGS GPLFVTEPSV TRSPTQAPFS PFNPTSLIKM EPQDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.