Details for: AZU1

Gene ID: 566

Symbol: AZU1

Ensembl ID: ENSG00000172232

Description: azurocidin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.64
    Marker Score: 2117
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.4
    Marker Score: 1546
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.3
    Marker Score: 577
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.21
    Marker Score: 767
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 657
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 381
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.89
    Marker Score: 384
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.82
    Marker Score: 597.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.61
    Marker Score: 1513
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 357
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.53
    Marker Score: 295
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.53
    Marker Score: 271
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.47
    Marker Score: 308
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.42
    Marker Score: 207
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 353
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.31
    Marker Score: 235
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.25
    Marker Score: 2196
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 391
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.21
    Marker Score: 731
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.2
    Marker Score: 378
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.19
    Marker Score: 576
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.18
    Marker Score: 285
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.18
    Marker Score: 6501
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.17
    Marker Score: 1594
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.16
    Marker Score: 10037
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 335
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 96
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.15
    Marker Score: 8651
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.15
    Marker Score: 112
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.15
    Marker Score: 110
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 538
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.12
    Marker Score: 726
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 166
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.11
    Marker Score: 437
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.11
    Marker Score: 111
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 144
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 941
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.11
    Marker Score: 130
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.11
    Marker Score: 2098
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1
    Marker Score: 435
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1
    Marker Score: 3771
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1
    Marker Score: 405
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1
    Marker Score: 991
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 83
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22

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Other Information

**Key characteristics:** * The AZU1 gene is located on chromosome 19p13.2. * It is a member of the CAP7 family of cell adhesion molecules. * The protein is expressed in high levels in cells of the immune system, including macrophages, neutrophils, and dendritic cells. * It is also expressed in cells of the nervous system, including neurons and glial cells. **Pathways and functions:** * The AZU1 protein is involved in the antimicrobial humoral response by binding to heparan sulfate proteoglycans on the surface of pathogens. This binding triggers a signaling cascade that leads to the activation of macrophages and the production of antimicrobial cytokines. * The AZU1 protein is also involved in the glial cell migration by binding to fibronectin and integrins on the surface of astrocytes. This binding triggers a signaling cascade that leads to the migration of astrocytes into sites of inflammation. * The AZU1 protein is also involved in the heparan sulfate proteoglycan binding. This binding is important for the regulation of cell migration and adhesion. **Clinical significance:** The AZU1 gene has been linked to a number of diseases, including cancer and autoimmune disorders. In cancer, the AZU1 gene is often overexpressed in tumor cells. This overexpression is associated with increased cell migration, invasion, and metastasis. The AZU1 gene is also a potential target for cancer therapy. Several drugs that target the AZU1 protein have been shown to be effective in inhibiting cancer growth in preclinical models.

Genular Protein ID: 2118109621

Symbol: CAP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20160 P80014 Q52LG4 Q9UCM1 Q9UCT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1919011

Title: Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.

PubMed ID: 1919011

PubMed ID: 1518849

Title: Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

PubMed ID: 1518849

DOI: 10.1073/pnas.89.17.8215

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2049091

Title: Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases.

PubMed ID: 2049091

DOI: 10.1016/0006-291x(91)91843-2

PubMed ID: 2226832

Title: Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase.

PubMed ID: 2226832

DOI: 10.1016/0014-5793(90)80484-z

PubMed ID: 2026172

Title: Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.

PubMed ID: 2026172

DOI: 10.1111/j.1432-1033.1991.tb15942.x

PubMed ID: 2332502

Title: CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.

PubMed ID: 2332502

DOI: 10.1172/jci114593

PubMed ID: 2406527

Title: CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases.

PubMed ID: 2406527

DOI: 10.1016/0024-3205(90)90104-y

PubMed ID: 1937776

Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.

PubMed ID: 1937776

DOI: 10.1128/iai.59.11.4193-4200.1991

PubMed ID: 1897955

Title: PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.

PubMed ID: 1897955

DOI: 10.1016/0003-9861(91)90042-h

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 2404977

Title: Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

PubMed ID: 2404977

DOI: 10.1016/s0021-9258(19)39936-3

PubMed ID: 1399008

Title: Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena.

PubMed ID: 1399008

DOI: 10.1128/iai.60.11.4973-4975.1992

PubMed ID: 26274980

Title: Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G.

PubMed ID: 26274980

DOI: 10.3390/biom5031832

PubMed ID: 2312733

Title: Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

PubMed ID: 2312733

DOI: 10.1172/jci114518

PubMed ID: 1755383

Title: Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.

PubMed ID: 1755383

DOI: 10.1007/978-1-4684-6009-4_11

PubMed ID: 8506327

Title: Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.

PubMed ID: 8506327

DOI: 10.1073/pnas.90.10.4733

PubMed ID: 10534120

Title: Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.

PubMed ID: 10534120

DOI: 10.1002/jlb.66.4.634

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9095193

Title: Structure of HBP, a multifunctional protein with a serine proteinase fold.

PubMed ID: 9095193

DOI: 10.1038/nsb0497-265

PubMed ID: 9761855

Title: Atomic resolution structure of human HBP/CAP37/azurocidin.

PubMed ID: 9761855

DOI: 10.1107/s0907444997016193

Sequence Information:

  • Length: 251
  • Mass: 26886
  • Checksum: 22F80D9EBE87DE60
  • Sequence:
    • MTRLTVLALL AGLLASSRAG SSPLLDIVGG RKARPRQFPF LASIQNQGRH FCGGALIHAR 
FVMTAASCFQ SQNPGVSTVV LGAYDLRRRE RQSRQTFSIS SMSENGYDPQ QNLNDLMLLQ 
LDREANLTSS VTILPLPLQN ATVEAGTRCQ VAGWGSQRSG GRLSRFPRFV NVTVTPEDQC 
RPNNVCTGVL TRRGGICNGD GGTPLVCEGL AHGVASFSLG PCGRGPDFFT RVALFRDWID 
GVLNNPGPGP A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.