Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 12.4723
Cell Significance Index: -1.9400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 5.6378
Cell Significance Index: -1.4300 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 5.0798
Cell Significance Index: 33.7000 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.4206
Cell Significance Index: 28.2200 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 2.8253
Cell Significance Index: 41.1800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.3545
Cell Significance Index: -1.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.6437
Cell Significance Index: -2.5400 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.3787
Cell Significance Index: 6.2400 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.2110
Cell Significance Index: 2.6700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1120
Cell Significance Index: 13.0500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0877
Cell Significance Index: 1.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0684
Cell Significance Index: 5.1000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0326
Cell Significance Index: 11.6900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0247
Cell Significance Index: 0.6400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0239
Cell Significance Index: 4.7900 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0212
Cell Significance Index: 0.3200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0190
Cell Significance Index: 10.3600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0099
Cell Significance Index: 1.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0098
Cell Significance Index: 1.2600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.0063
Cell Significance Index: 0.0400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0060
Cell Significance Index: 0.1100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0058
Cell Significance Index: 0.1000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0032
Cell Significance Index: 1.4100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0031
Cell Significance Index: 0.1600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0007
Cell Significance Index: 1.3900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0004
Cell Significance Index: -0.5800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0008
Cell Significance Index: -1.5100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0011
Cell Significance Index: -0.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0012
Cell Significance Index: -1.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0020
Cell Significance Index: -0.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0031
Cell Significance Index: -2.3000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0035
Cell Significance Index: -2.2500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0036
Cell Significance Index: -2.7200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0036
Cell Significance Index: -0.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0039
Cell Significance Index: -2.2200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0043
Cell Significance Index: -0.0900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0052
Cell Significance Index: -2.3700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0056
Cell Significance Index: -0.7700 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0061
Cell Significance Index: -0.0900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0065
Cell Significance Index: -1.8700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0069
Cell Significance Index: -1.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0107
Cell Significance Index: -1.8300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0114
Cell Significance Index: -1.4000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0127
Cell Significance Index: -1.8400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0130
Cell Significance Index: -2.7400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0144
Cell Significance Index: -0.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0145
Cell Significance Index: -1.4800 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.0151
Cell Significance Index: -0.1500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0168
Cell Significance Index: -1.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0174
Cell Significance Index: -2.2500 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0179
Cell Significance Index: -0.2700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0182
Cell Significance Index: -0.2600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0186
Cell Significance Index: -0.3200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0187
Cell Significance Index: -2.1400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0203
Cell Significance Index: -1.3100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0221
Cell Significance Index: -2.3000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0224
Cell Significance Index: -2.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0244
Cell Significance Index: -1.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0259
Cell Significance Index: -1.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0282
Cell Significance Index: -0.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0286
Cell Significance Index: -2.2000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0305
Cell Significance Index: -1.3500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0306
Cell Significance Index: -0.6500 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0313
Cell Significance Index: -0.2900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0320
Cell Significance Index: -1.1200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0322
Cell Significance Index: -1.4600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0333
Cell Significance Index: -1.0900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0341
Cell Significance Index: -1.2900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0341
Cell Significance Index: -1.5900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.0374
Cell Significance Index: -0.2300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0376
Cell Significance Index: -1.3200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0378
Cell Significance Index: -1.9700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0394
Cell Significance Index: -0.6600 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0394
Cell Significance Index: -0.3400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0430
Cell Significance Index: -1.8700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0430
Cell Significance Index: -2.2600 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0432
Cell Significance Index: -0.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0436
Cell Significance Index: -1.3900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0453
Cell Significance Index: -1.1300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0454
Cell Significance Index: -0.7200 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.0458
Cell Significance Index: -0.2400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0463
Cell Significance Index: -1.0000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0480
Cell Significance Index: -0.9500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0503
Cell Significance Index: -1.0500 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0510
Cell Significance Index: -0.6000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0528
Cell Significance Index: -1.2200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0545
Cell Significance Index: -1.1000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0562
Cell Significance Index: -2.0600 - Cell Name: immature neutrophil (CL0000776)
Fold Change: -0.0564
Cell Significance Index: -0.4300 - Cell Name: neuron (CL0000540)
Fold Change: -0.0580
Cell Significance Index: -0.5500 - Cell Name: promonocyte (CL0000559)
Fold Change: -0.0580
Cell Significance Index: -0.6200 - Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: -0.0640
Cell Significance Index: -0.5400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0665
Cell Significance Index: -1.8100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0670
Cell Significance Index: -1.9300 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0671
Cell Significance Index: -0.7500 - Cell Name: glioblast (CL0000030)
Fold Change: -0.0701
Cell Significance Index: -0.4400 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0705
Cell Significance Index: -0.9900 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0708
Cell Significance Index: -0.4200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0723
Cell Significance Index: -1.9000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0727
Cell Significance Index: -2.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2118109621
Symbol: CAP7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1919011
Title: Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.
PubMed ID: 1919011
PubMed ID: 1518849
Title: Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.
PubMed ID: 1518849
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2049091
Title: Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases.
PubMed ID: 2049091
PubMed ID: 2226832
Title: Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase.
PubMed ID: 2226832
PubMed ID: 2026172
Title: Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.
PubMed ID: 2026172
PubMed ID: 2332502
Title: CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.
PubMed ID: 2332502
DOI: 10.1172/jci114593
PubMed ID: 2406527
Title: CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases.
PubMed ID: 2406527
PubMed ID: 1937776
Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.
PubMed ID: 1937776
PubMed ID: 1897955
Title: PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.
PubMed ID: 1897955
PubMed ID: 2501794
Title: Antibiotic proteins of human polymorphonuclear leukocytes.
PubMed ID: 2501794
PubMed ID: 2404977
Title: Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.
PubMed ID: 2404977
PubMed ID: 1399008
Title: Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena.
PubMed ID: 1399008
PubMed ID: 26274980
Title: Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G.
PubMed ID: 26274980
DOI: 10.3390/biom5031832
PubMed ID: 2312733
Title: Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.
PubMed ID: 2312733
DOI: 10.1172/jci114518
PubMed ID: 1755383
Title: Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.
PubMed ID: 1755383
PubMed ID: 8506327
Title: Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.
PubMed ID: 8506327
PubMed ID: 10534120
Title: Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
PubMed ID: 10534120
DOI: 10.1002/jlb.66.4.634
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9095193
Title: Structure of HBP, a multifunctional protein with a serine proteinase fold.
PubMed ID: 9095193
DOI: 10.1038/nsb0497-265
PubMed ID: 9761855
Title: Atomic resolution structure of human HBP/CAP37/azurocidin.
PubMed ID: 9761855
Sequence Information:
- Length: 251
- Mass: 26886
- Checksum: 22F80D9EBE87DE60
- Sequence:
MTRLTVLALL AGLLASSRAG SSPLLDIVGG RKARPRQFPF LASIQNQGRH FCGGALIHAR FVMTAASCFQ SQNPGVSTVV LGAYDLRRRE RQSRQTFSIS SMSENGYDPQ QNLNDLMLLQ LDREANLTSS VTILPLPLQN ATVEAGTRCQ VAGWGSQRSG GRLSRFPRFV NVTVTPEDQC RPNNVCTGVL TRRGGICNGD GGTPLVCEGL AHGVASFSLG PCGRGPDFFT RVALFRDWID GVLNNPGPGP A
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.