AZU1 | ENSG00000172232 | NCBI 566

Details for: AZU1

Gene ID: 566

Symbol: AZU1

Ensembl ID: ENSG00000172232

Description: azurocidin 1

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Antimicrobial humoral response
(GO:0019730)
Azurophil granule
(GO:0042582)
Azurophil granule lumen
(GO:0035578)
Azurophil granule membrane
(GO:0035577)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Cell chemotaxis
(GO:0060326)
Cellular extravasation
(GO:0045123)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to virus
(GO:0051607)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell migration
(GO:0008347)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Intracellular membrane-bounded organelle
(GO:0043231)
Macrophage chemotaxis
(GO:0048246)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Monocyte activation
(GO:0042117)
Negative regulation of apoptotic process
(GO:0043066)
Neutrophil-mediated killing of bacterium
(GO:0070944)
Peptidase activity
(GO:0008233)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of fractalkine production
(GO:0032724)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of mhc class ii biosynthetic process
(GO:0045348)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein kinase c signaling
(GO:0070528)
Proteolysis
(GO:0006508)
Regulation of vascular permeability
(GO:0043114)
Serine-type endopeptidase activity
(GO:0004252)
Toxic substance binding
(GO:0015643)

Other Information

Proteins

CAP7_HUMAN

Genular Protein ID: 2118109621

Symbol: CAP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20160 P80014 Q52LG4 Q9UCM1 Q9UCT5

Database IDs:

Citations:

PubMed ID: 1919011

Title: Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.

PubMed ID: 1919011

PubMed ID: 1518849

Title: Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

PubMed ID: 1518849

DOI: 10.1073/pnas.89.17.8215

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2049091

Title: Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases.

PubMed ID: 2049091

DOI: 10.1016/0006-291x(91)91843-2

PubMed ID: 2226832

Title: Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase.

PubMed ID: 2226832

DOI: 10.1016/0014-5793(90)80484-z

PubMed ID: 2026172

Title: Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.

PubMed ID: 2026172

DOI: 10.1111/j.1432-1033.1991.tb15942.x

PubMed ID: 2332502

Title: CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.

PubMed ID: 2332502

DOI: 10.1172/jci114593

PubMed ID: 2406527

Title: CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases.

PubMed ID: 2406527

DOI: 10.1016/0024-3205(90)90104-y

PubMed ID: 1937776

Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.

PubMed ID: 1937776

DOI: 10.1128/iai.59.11.4193-4200.1991

PubMed ID: 1897955

Title: PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.

PubMed ID: 1897955

DOI: 10.1016/0003-9861(91)90042-h

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 2404977

Title: Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

PubMed ID: 2404977

DOI: 10.1016/s0021-9258(19)39936-3

PubMed ID: 1399008

Title: Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena.

PubMed ID: 1399008

DOI: 10.1128/iai.60.11.4973-4975.1992

PubMed ID: 26274980

Title: Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G.

PubMed ID: 26274980

DOI: 10.3390/biom5031832

PubMed ID: 2312733

Title: Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

PubMed ID: 2312733

DOI: 10.1172/jci114518

PubMed ID: 1755383

Title: Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.

PubMed ID: 1755383

DOI: 10.1007/978-1-4684-6009-4_11

PubMed ID: 8506327

Title: Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.

PubMed ID: 8506327

DOI: 10.1073/pnas.90.10.4733

PubMed ID: 10534120

Title: Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.

PubMed ID: 10534120

DOI: 10.1002/jlb.66.4.634

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9095193

Title: Structure of HBP, a multifunctional protein with a serine proteinase fold.

PubMed ID: 9095193

DOI: 10.1038/nsb0497-265

PubMed ID: 9761855

Title: Atomic resolution structure of human HBP/CAP37/azurocidin.

PubMed ID: 9761855

DOI: 10.1107/s0907444997016193

Sequence Information:

Length: 251
Mass: 26886
Checksum: 22F80D9EBE87DE60
Sequence:

MTRLTVLALL AGLLASSRAG SSPLLDIVGG RKARPRQFPF LASIQNQGRH FCGGALIHAR 
FVMTAASCFQ SQNPGVSTVV LGAYDLRRRE RQSRQTFSIS SMSENGYDPQ QNLNDLMLLQ 
LDREANLTSS VTILPLPLQN ATVEAGTRCQ VAGWGSQRSG GRLSRFPRFV NVTVTPEDQC 
RPNNVCTGVL TRRGGICNGD GGTPLVCEGL AHGVASFSLG PCGRGPDFFT RVALFRDWID 
GVLNNPGPGP A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AZU1

Associated with

Other Information

Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. PubMed ID: 1919011

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. PubMed ID: 1518849

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. PubMed ID: 2049091

Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase. PubMed ID: 2226832

Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities. PubMed ID: 2026172

CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. PubMed ID: 2332502

CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. PubMed ID: 2406527

Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. PubMed ID: 1937776

PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors. PubMed ID: 1897955

Antibiotic proteins of human polymorphonuclear leukocytes. PubMed ID: 2501794

Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase. PubMed ID: 2404977

Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena. PubMed ID: 1399008

Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G. PubMed ID: 26274980

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. PubMed ID: 2312733

Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. PubMed ID: 1755383

Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. PubMed ID: 8506327

Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin. PubMed ID: 10534120

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of HBP, a multifunctional protein with a serine proteinase fold. PubMed ID: 9095193

Atomic resolution structure of human HBP/CAP37/azurocidin. PubMed ID: 9761855