ASAH2 | ENSG00000188611 | NCBI 56624

Details for: ASAH2

Gene ID: 56624

Symbol: ASAH2

Ensembl ID: ENSG00000188611

Description: N-acylsphingosine amidohydrolase 2

Associated with

Glycosphingolipid catabolism
(R-HSA-9840310)
Glycosphingolipid metabolism
(R-HSA-1660662)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Sphingolipid metabolism
(R-HSA-428157)
Apoptotic process
(GO:0006915)
Calcium ion binding
(GO:0005509)
Caveola
(GO:0005901)
Cellular response to cytokine stimulus
(GO:0071345)
Ceramidase activity
(GO:0102121)
Ceramide biosynthetic process
(GO:0046513)
Ceramide catabolic process
(GO:0046514)
Ceramide metabolic process
(GO:0006672)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Lipid digestion
(GO:0044241)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Membrane raft
(GO:0045121)
Mitochondrion
(GO:0005739)
N-acylsphingosine amidohydrolase activity
(GO:0017040)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Plasma membrane
(GO:0005886)
Regulation of mitotic cell cycle
(GO:0007346)
Sphingosine biosynthetic process
(GO:0046512)
Sphingosine metabolic process
(GO:0006670)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Acylsphingosine deacylase 2

Genular Protein ID: 1776828326

Symbol: ASAH2_HUMAN

Name: Acylsphingosine deacylase 2

UniProtKB Accession Codes:

Q9NR71 Q3KNU1 Q5SNT7 Q5SZP6 Q5SZP7 Q5T1D5 Q71ME6

Database IDs:

Citations:

PubMed ID: 14557071

Title: Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.

PubMed ID: 14557071

DOI: 10.1016/s0378-1119(03)00721-2

PubMed ID: 15946935

Title: Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

PubMed ID: 15946935

DOI: 10.1074/jbc.m503002200

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 10781606

Title: Molecular cloning and characterization of a human mitochondrial ceramidase.

PubMed ID: 10781606

DOI: 10.1074/jbc.m002522200

PubMed ID: 11278489

Title: Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.

PubMed ID: 11278489

DOI: 10.1074/jbc.m009331200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15845354

Title: Subcellular localization of human neutral ceramidase expressed in HEK293 cells.

PubMed ID: 15845354

DOI: 10.1016/j.bbrc.2005.03.134

PubMed ID: 16061940

Title: Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.

PubMed ID: 16061940

DOI: 10.1194/jlr.m500268-jlr200

PubMed ID: 16229686

Title: Identification of a novel amidase motif in neutral ceramidase.

PubMed ID: 16229686

DOI: 10.1042/bj20050682

PubMed ID: 17475390

Title: Purification and characterization of human intestinal neutral ceramidase.

PubMed ID: 17475390

DOI: 10.1016/j.biochi.2007.03.009

PubMed ID: 17334805

Title: A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.

PubMed ID: 17334805

DOI: 10.1007/s10048-007-0081-5

PubMed ID: 19345744

Title: Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.

PubMed ID: 19345744

DOI: 10.1016/j.bbalip.2009.03.012

PubMed ID: 24798654

Title: Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect.

PubMed ID: 24798654

DOI: 10.1111/febs.12826

PubMed ID: 30154232

Title: Functions of neutral ceramidase in the Golgi apparatus.

PubMed ID: 30154232

DOI: 10.1194/jlr.m088187

PubMed ID: 26190575

Title: Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.

PubMed ID: 26190575

DOI: 10.1016/j.str.2015.06.013

Sequence Information:

Length: 780
Mass: 85516
Checksum: D2BD7947B022A619
Sequence:

MAKRTFSNLE TFLIFLLVMM SAITVALLSL LFITSGTIEN HKDLGGHFFS TTQSPPATQG 
STAAQRSTAT QHSTATQSST ATQTSPVPLT PESPLFQNFS GYHIGVGRAD CTGQVADINL 
MGYGKSGQNA QGILTRLYSR AFIMAEPDGS NRTVFVSIDI GMVSQRLRLE VLNRLQSKYG 
SLYRRDNVIL SGTHTHSGPA GYFQYTVFVI ASEGFSNQTF QHMVTGILKS IDIAHTNMKP 
GKIFINKGNV DGVQINRSPY SYLQNPQSER ARYSSNTDKE MIVLKMVDLN GDDLGLISWF 
AIHPVSMNNS NHLVNSDNVG YASYLLEQEK NKGYLPGQGP FVAAFASSNL GDVSPNILGP 
RCINTGESCD NANSTCPIGG PSMCIAKGPG QDMFDSTQII GRAMYQRAKE LYASASQEVT 
GPLASAHQWV DMTDVTVWLN STHASKTCKP ALGYSFAAGT IDGVGGLNFT QGKTEGDPFW 
DTIRDQILGK PSEEIKECHK PKPILLHTGE LSKPHPWHPD IVDVQIITLG SLAITAIPGE 
FTTMSGRRLR EAVQAEFASH GMQNMTVVIS GLCNVYTHYI TTYEEYQAQR YEAASTIYGP 
HTLSAYIQLF RNLAKAIATD TVANLSRGPE PPFFKQLIVP LIPSIVDRAP KGRTFGDVLQ 
PAKPEYRVGE VAEVIFVGAN PKNSVQNQTH QTFLTVEKYE ATSTSWQIVC NDASWETRFY 
WHKGLLGLSN ATVEWHIPDT AQPGIYRIRY FGHNRKQDIL KPAVILSFEG TSPAFEVVTI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ASAH2

Associated with

Other Information

Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. PubMed ID: 14557071

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. PubMed ID: 15946935

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Molecular cloning and characterization of a human mitochondrial ceramidase. PubMed ID: 10781606

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. PubMed ID: 11278489

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Subcellular localization of human neutral ceramidase expressed in HEK293 cells. PubMed ID: 15845354

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. PubMed ID: 16061940

Identification of a novel amidase motif in neutral ceramidase. PubMed ID: 16229686

Purification and characterization of human intestinal neutral ceramidase. PubMed ID: 17475390

A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. PubMed ID: 17334805

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. PubMed ID: 19345744

Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect. PubMed ID: 24798654

Functions of neutral ceramidase in the Golgi apparatus. PubMed ID: 30154232

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. PubMed ID: 26190575