Gsk3b | ENSMUSG00000022812 | NCBI 56637

Details for: Gsk3b

Gene ID: 56637

Symbol: Gsk3b

Ensembl ID: ENSMUSG00000022812

Description: glycogen synthase kinase 3 beta

Associated with

Axon guidance
(R-MMU-422475)
B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Beta-catenin phosphorylation cascade
(R-MMU-196299)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to heat stress
(R-MMU-3371556)
Crmps in sema3a signaling
(R-MMU-399956)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Developmental biology
(R-MMU-1266738)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Epigenetic regulation of gene expression
(R-MMU-212165)
Gene expression (transcription)
(R-MMU-74160)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-MMU-9762114)
Hedgehog 'off' state
(R-MMU-5610787)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Nuclear events mediated by nfe2l2
(R-MMU-9759194)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Semaphorin interactions
(R-MMU-373755)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Animal organ morphogenesis
(GO:0009887)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Beta-catenin binding
(GO:0008013)
Carbohydrate metabolic process
(GO:0005975)
Circadian rhythm
(GO:0007623)
Cytoskeleton organization
(GO:0007010)
Dynactin binding
(GO:0034452)
Dynein complex binding
(GO:0070840)
Epithelial to mesenchymal transition
(GO:0001837)
Er overload response
(GO:0006983)
Establishment or maintenance of cell polarity
(GO:0007163)
Glycogen metabolic process
(GO:0005977)
Insulin receptor signaling pathway
(GO:0008286)
Integrin binding
(GO:0005178)
Ionotropic glutamate receptor binding
(GO:0035255)
Kinase activity
(GO:0016301)
Meiosis i
(GO:0007127)
Multicellular organism development
(GO:0007275)
Myoblast fusion
(GO:0007520)
Myotube differentiation
(GO:0014902)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron maturation
(GO:0014043)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of signal transduction
(GO:0009968)
Nervous system development
(GO:0007399)
Nf-kappab binding
(GO:0051059)
Nucleotide binding
(GO:0000166)
P53 binding
(GO:0002039)
Phosphorylation
(GO:0016310)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of mitochondrion organization
(GO:0010822)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine/threonine kinase binding
(GO:0120283)
Protein serine kinase activity
(GO:0106310)
Re-entry into mitotic cell cycle
(GO:0000320)
Regulation of cell growth
(GO:0001558)
Regulation of neuron projection development
(GO:0010975)
Response to zinc ion
(GO:0010043)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Transcription by rna polymerase ii
(GO:0006366)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Glycogen synthase kinase-3 beta
E9QAQ5_MOUSE

Genular Protein ID: 3041676176

Symbol: GSK3B_MOUSE

Name: Glycogen synthase kinase-3 beta

UniProtKB Accession Codes:

Q9WV60

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10894547

Title: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.

PubMed ID: 10894547

DOI: 10.1038/35017574

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16051150

Title: An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

PubMed ID: 16051150

DOI: 10.1016/j.cell.2005.05.012

PubMed ID: 15791206

Title: Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.

PubMed ID: 15791206

DOI: 10.1038/sj.emboj.7600633

PubMed ID: 16543145

Title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

PubMed ID: 16543145

DOI: 10.1016/j.molcel.2006.02.009

PubMed ID: 17391670

Title: GSK3 alpha and GSK3 beta are necessary for axon formation.

PubMed ID: 17391670

DOI: 10.1016/j.febslet.2007.03.018

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18288891

Title: Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

PubMed ID: 18288891

DOI: 10.1371/journal.pbio.0060037

PubMed ID: 19303846

Title: Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

PubMed ID: 19303846

DOI: 10.1016/j.cell.2008.12.044

PubMed ID: 19141611

Title: Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.

PubMed ID: 19141611

DOI: 10.1074/jbc.m807753200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20123978

Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.

PubMed ID: 20123978

DOI: 10.1128/mcb.01047-09

PubMed ID: 20049328

Title: Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.

PubMed ID: 20049328

DOI: 10.1371/journal.pone.0008561

PubMed ID: 21295697

Title: Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta.

PubMed ID: 21295697

DOI: 10.1016/j.cell.2010.12.033

PubMed ID: 22057101

Title: ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.

PubMed ID: 22057101

DOI: 10.1038/ncb2373

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23395175

Title: Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.

PubMed ID: 23395175

DOI: 10.1016/j.cmet.2012.12.017

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

PubMed ID: 24742671

Title: Glycogen synthase kinase-3beta stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia.

PubMed ID: 24742671

DOI: 10.1074/jbc.m114.551747

PubMed ID: 26240334

Title: FXR1P is a GSK3beta substrate regulating mood and emotion processing.

PubMed ID: 26240334

DOI: 10.1073/pnas.1506491112

PubMed ID: 27827363

Title: Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

PubMed ID: 27827363

DOI: 10.1038/ncomms13267

PubMed ID: 28556462

Title: GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity.

PubMed ID: 28556462

DOI: 10.1002/hipo.22739

PubMed ID: 29142209

Title: Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

PubMed ID: 29142209

DOI: 10.1038/s41467-017-01199-8

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 28098160

Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.

PubMed ID: 28098160

DOI: 10.1038/srep40313

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

Sequence Information:

Length: 420
Mass: 46710
Checksum: 200C3FD1B38B4883
Sequence:

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 
NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT NAGDRGQTNN AASASASNST

Genular Protein ID: 1566863108

Symbol: E9QAQ5_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9QAQ5

Database IDs:

Citations:

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.M400085-MCP200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 433
Mass: 47990
Checksum: 901D4D23D958F2D4
Sequence:

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 
WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN 
VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA ASPPANATAA SDTNAGDRGQ 
TNNAASASAS NST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gsk3b

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. PubMed ID: 10894547

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. PubMed ID: 16051150

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. PubMed ID: 15791206

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. PubMed ID: 16543145

GSK3 alpha and GSK3 beta are necessary for axon formation. PubMed ID: 17391670

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PubMed ID: 18288891

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. PubMed ID: 19303846

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. PubMed ID: 19141611

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. PubMed ID: 20123978

Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PubMed ID: 20049328

Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta. PubMed ID: 21295697

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. PubMed ID: 22057101

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. PubMed ID: 22539723

Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. PubMed ID: 23395175

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741

Glycogen synthase kinase-3beta stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia. PubMed ID: 24742671

FXR1P is a GSK3beta substrate regulating mood and emotion processing. PubMed ID: 26240334

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. PubMed ID: 27827363

GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. PubMed ID: 28556462

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. PubMed ID: 29142209

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. PubMed ID: 28903391

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. PubMed ID: 28098160

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 15489334

PubMed ID: 10894547

PubMed ID: 15345747

PubMed ID: 16051150

PubMed ID: 15791206

PubMed ID: 16543145

PubMed ID: 17391670

PubMed ID: 17242355

PubMed ID: 18288891

PubMed ID: 19303846

PubMed ID: 19141611

PubMed ID: 21183079

PubMed ID: 20123978

PubMed ID: 20049328

PubMed ID: 21295697

PubMed ID: 22057101

PubMed ID: 22539723

PubMed ID: 23395175

PubMed ID: 23542741

PubMed ID: 24742671

PubMed ID: 26240334

PubMed ID: 27827363

PubMed ID: 28556462

PubMed ID: 29142209

PubMed ID: 28903391

PubMed ID: 28098160

PubMed ID: 31073040

PubMed ID: 15345747

PubMed ID: 17242355

PubMed ID: 19468303

PubMed ID: 21183079