TRIM39 | ENSG00000204599 | NCBI 56658

Details for: TRIM39

Gene ID: 56658

Symbol: TRIM39

Ensembl ID: ENSG00000204599

Description: tripartite motif containing 39

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Apoptotic process
(GO:0006915)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Mitochondrion
(GO:0005739)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032435)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Nucleus
(GO:0005634)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Protein ubiquitination
(GO:0016567)
Regulation of cell cycle g1/s phase transition
(GO:1902806)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase TRIM39

Genular Protein ID: 3650948811

Symbol: TRI39_HUMAN

Name: E3 ubiquitin-protein ligase TRIM39

UniProtKB Accession Codes:

Q9HCM9 Q5STG3 Q5STG4 Q76BL3 Q8IYT9 Q96IB6

Database IDs:

Citations:

PubMed ID: 11006080

Title: Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC.

PubMed ID: 11006080

DOI: 10.1006/bbrc.2000.3380

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19100260

Title: TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.

PubMed ID: 19100260

DOI: 10.1016/j.yexcr.2008.11.021

PubMed ID: 22529100

Title: The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.

PubMed ID: 22529100

DOI: 10.1083/jcb.201111141

PubMed ID: 23213251

Title: TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.

PubMed ID: 23213251

DOI: 10.1073/pnas.1214156110

PubMed ID: 26363554

Title: TRIM39 negatively regulates the NFkappaB-mediated signaling pathway through stabilization of Cactin.

PubMed ID: 26363554

DOI: 10.1007/s00018-015-2040-x

Sequence Information:

Length: 518
Mass: 59690
Checksum: 2F946F518B217153
Sequence:

MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL 
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE 
DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG 
ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL 
AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE 
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK 
FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL 
TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI 
YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM39

Associated with

Other Information

Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. PubMed ID: 11006080

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. PubMed ID: 16702430

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. PubMed ID: 19100260

The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. PubMed ID: 22529100

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PubMed ID: 23213251

TRIM39 negatively regulates the NFkappaB-mediated signaling pathway through stabilization of Cactin. PubMed ID: 26363554