Gene B2M - ENSG00000166710 | NCBI Gene ID: 567

Details for: B2M

Gene ID: 567

Symbol: B2M

Ensembl ID: ENSG00000166710

Description: beta-2-microglobulin

Associated with

Adaptive immune system
(R-HSA-1280218)
Amyloid fiber formation
(R-HSA-977225)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Antigen processing-cross presentation
(R-HSA-1236975)
Bacterial infection pathways
(R-HSA-9824439)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Disease
(R-HSA-1643685)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Er-phagosome pathway
(R-HSA-1236974)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Modulation by mtb of host immune system
(R-HSA-9637628)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated downregulation of mhc class i complex cell surface expression
(R-HSA-164940)
Neutrophil degranulation
(R-HSA-6798695)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Viral infection pathways
(R-HSA-9824446)
Amyloid fibril formation
(GO:1990000)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Cellular response to iron(iii) ion
(GO:0071283)
Cellular response to iron ion
(GO:0071281)
Cellular response to nicotine
(GO:0071316)
Cytosol
(GO:0005829)
Early endosome lumen
(GO:0031905)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Er to golgi transport vesicle membrane
(GO:0012507)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion transport
(GO:0006826)
Late endosome membrane
(GO:0031902)
Learning or memory
(GO:0007611)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein complex
(GO:0042612)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of forebrain neuron differentiation
(GO:2000978)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of receptor binding
(GO:1900121)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide antigen binding
(GO:0042605)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of ferrous iron binding
(GO:1904434)
Positive regulation of immune response
(GO:0050778)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell cytokine production
(GO:0002726)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of transferrin receptor binding
(GO:1904437)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein refolding
(GO:0042026)
Recycling endosome membrane
(GO:0055038)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of iron ion transport
(GO:0034756)
Response to molecule of bacterial origin
(GO:0002237)
Sensory perception of smell
(GO:0007608)
Specific granule lumen
(GO:0035580)
Structural molecule activity
(GO:0005198)
T cell differentiation in thymus
(GO:0033077)
T cell mediated cytotoxicity
(GO:0001913)
Tertiary granule lumen
(GO:1904724)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secretory cell (CL0000151)
Fold Change: 6.26
Marker Score: 11427
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 6.01
Marker Score: 15265.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.87
Marker Score: 4255
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.81
Marker Score: 12187
Cell Name: lymphocyte (CL0000542)
Fold Change: 5.79
Marker Score: 2922
Cell Name: naive T cell (CL0000898)
Fold Change: 5.67
Marker Score: 3652
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.64
Marker Score: 4800
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.62
Marker Score: 2887
Cell Name: malignant cell (CL0001064)
Fold Change: 5.6
Marker Score: 75187
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.55
Marker Score: 16200
Cell Name: mature T cell (CL0002419)
Fold Change: 5.38
Marker Score: 53323
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.26
Marker Score: 6856
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.2
Marker Score: 4165
Cell Name: endocardial cell (CL0002350)
Fold Change: 5.19
Marker Score: 2935
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.1
Marker Score: 173551
Cell Name: stromal cell (CL0000499)
Fold Change: 5.08
Marker Score: 5957
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 5.06
Marker Score: 3832.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.99
Marker Score: 7689
Cell Name: memory T cell (CL0000813)
Fold Change: 4.9
Marker Score: 2107
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.88
Marker Score: 15388
Cell Name: theca cell (CL0000503)
Fold Change: 4.84
Marker Score: 3468.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.83
Marker Score: 255276
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.76
Marker Score: 5877
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.71
Marker Score: 24774
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.66
Marker Score: 29761
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.66
Marker Score: 5180.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.66
Marker Score: 260524
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.63
Marker Score: 1107
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.6
Marker Score: 5545
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.56
Marker Score: 6601
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.56
Marker Score: 1481
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.55
Marker Score: 12187
Cell Name: endothelial cell (CL0000115)
Fold Change: 4.54
Marker Score: 4073
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 4.5
Marker Score: 6541
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.46
Marker Score: 7646
Cell Name: naive B cell (CL0000788)
Fold Change: 4.44
Marker Score: 3965
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 4.42
Marker Score: 3011
Cell Name: blood cell (CL0000081)
Fold Change: 4.42
Marker Score: 51370
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.36
Marker Score: 3101
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.36
Marker Score: 2653
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.34
Marker Score: 10954
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.34
Marker Score: 11994
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.29
Marker Score: 4149
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.28
Marker Score: 10451.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.27
Marker Score: 11968.5
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 4.24
Marker Score: 1099
Cell Name: fibroblast (CL0000057)
Fold Change: 4.21
Marker Score: 4065
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 4.2
Marker Score: 4009
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.2
Marker Score: 2462
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.18
Marker Score: 31103
Cell Name: neutrophil (CL0000775)
Fold Change: 4.16
Marker Score: 2536
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 4.15
Marker Score: 3572.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.13
Marker Score: 3238.5
Cell Name: myelocyte (CL0002193)
Fold Change: 4.12
Marker Score: 1780.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.12
Marker Score: 26826.5
Cell Name: mature microglial cell (CL0002629)
Fold Change: 4.11
Marker Score: 1486.5
Cell Name: platelet (CL0000233)
Fold Change: 4.1
Marker Score: 1855
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.1
Marker Score: 17567
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.1
Marker Score: 6030.5
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.09
Marker Score: 938
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 4.08
Marker Score: 4393
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.07
Marker Score: 3472.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.03
Marker Score: 4305
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 4.02
Marker Score: 3579
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.02
Marker Score: 53076
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.01
Marker Score: 3946
Cell Name: supporting cell (CL0000630)
Fold Change: 4
Marker Score: 7514
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.99
Marker Score: 14180
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.99
Marker Score: 1281.5
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 3.99
Marker Score: 868
Cell Name: paneth cell (CL0000510)
Fold Change: 3.99
Marker Score: 2777
Cell Name: club cell (CL0000158)
Fold Change: 3.98
Marker Score: 4650
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.98
Marker Score: 2195
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.97
Marker Score: 1052
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.97
Marker Score: 2441
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.92
Marker Score: 1114
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.92
Marker Score: 1104
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.89
Marker Score: 1025
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.89
Marker Score: 2013
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.89
Marker Score: 966
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.88
Marker Score: 33669
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.86
Marker Score: 3403
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.85
Marker Score: 3901
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.84
Marker Score: 3423
Cell Name: reticular cell (CL0000432)
Fold Change: 3.82
Marker Score: 1395.5
Cell Name: granulocyte (CL0000094)
Fold Change: 3.82
Marker Score: 1713
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.82
Marker Score: 3214
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.82
Marker Score: 1089
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.81
Marker Score: 1010
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.81
Marker Score: 4361
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 3.8
Marker Score: 8561
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 3.79
Marker Score: 1036
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.79
Marker Score: 3151
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.78
Marker Score: 1041
Cell Name: immature B cell (CL0000816)
Fold Change: 3.77
Marker Score: 2500
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.77
Marker Score: 4098.5
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 3.77
Marker Score: 1569.5
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.76
Marker Score: 1297
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.76
Marker Score: 3191
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.76
Marker Score: 2201.5

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**Key characteristics:** * B2M is a glycoprotein that is expressed on the surface of cells. * It is a member of the immunoglobulin superfamily. * It is involved in the regulation of inflammation and cell migration. * It is also involved in the processing and presentation of antigens. **Pathways and functions:** * B2M is involved in the adaptive immune system, where it helps to regulate the immune response to pathogens. * It is involved in the processing and presentation of antigens, which is essential for the adaptive immune system to recognize and respond to foreign pathogens. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance:** * Mutations in the B2M gene have been linked to a number of human diseases, including rheumatoid arthritis, Crohn's disease, and cancer. * B2M is a potential therapeutic target for these diseases, as it can be used to block the effects of the disease. **Additional information:** * B2M is a highly conserved protein, with a sequence that is found in mammals, birds, and fish. * It is a secreted protein, which means that it is not a transmembrane protein. * It is a multi-functional protein, with a variety of roles in the immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Beta-2-microglobulin

Genular Protein ID: 2050760643

Symbol: B2MG_HUMAN

Name: Beta-2-microglobulin

UniProtKB Accession Codes:

P61769 P01884 Q540F8 Q6IAT8 Q9UCK0 Q9UD48 Q9UDF4

Database IDs:

Citations:

PubMed ID: 3312414

Title: The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

PubMed ID: 3312414

PubMed ID: 16108498

Title: Cloning of human beta-microglobulin gene and its high expression in Escherichia coli.

PubMed ID: 16108498

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11894933

Title: The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon.

PubMed ID: 11894933

DOI: 10.1002/j.1460-2075.1983.tb01412.x

PubMed ID: 6171820

Title: Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.

PubMed ID: 6171820

DOI: 10.1073/pnas.78.11.6613

PubMed ID: 4586824

Title: The complete amino acid sequence of beta 2-microglobulin.

PubMed ID: 4586824

DOI: 10.1021/bi00748a001

PubMed ID: 3532124

Title: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis.

PubMed ID: 3532124

DOI: 10.1073/pnas.83.20.7908

PubMed ID: 1336137

Title: Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients.

PubMed ID: 1336137

PubMed ID: 8084451

Title: Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin.

PubMed ID: 8084451

PubMed ID: 7554280

Title: Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood.

PubMed ID: 7554280

DOI: 10.1016/0009-8981(95)06039-g

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 25356553

Title: The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage.

PubMed ID: 25356553

DOI: 10.1371/journal.ppat.1004446

PubMed ID: 7918443

Title: Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites.

PubMed ID: 7918443

DOI: 10.1021/bi00206a026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22693999

Title: Hereditary systemic amyloidosis due to Asp76Asn variant beta2-microglobulin.

PubMed ID: 22693999

DOI: 10.1056/nejmoa1201356

PubMed ID: 3309677

Title: Structure of the human class I histocompatibility antigen, HLA-A2.

PubMed ID: 3309677

DOI: 10.1038/329506a0

PubMed ID: 2038058

Title: Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution.

PubMed ID: 2038058

DOI: 10.1016/0022-2836(91)90567-p

PubMed ID: 1390678

Title: 1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.

PubMed ID: 1390678

DOI: 10.1021/bi00152a030

PubMed ID: 7862664

Title: The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.

PubMed ID: 7862664

DOI: 10.1073/pnas.92.4.1218

PubMed ID: 8624812

Title: Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.

PubMed ID: 8624812

DOI: 10.1016/s1074-7613(00)80430-6

PubMed ID: 12119416

Title: Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.

PubMed ID: 12119416

DOI: 10.1073/pnas.152337399

PubMed ID: 12796775

Title: A structural basis for immunodominant human T cell receptor recognition.

PubMed ID: 12796775

DOI: 10.1038/ni942

PubMed ID: 16901902

Title: Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis.

PubMed ID: 16901902

DOI: 10.1074/jbc.m605358200

PubMed ID: 16491088

Title: A native to amyloidogenic transition regulated by a backbone trigger.

PubMed ID: 16491088

DOI: 10.1038/nsmb1068

PubMed ID: 17056715

Title: Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).

PubMed ID: 17056715

DOI: 10.1073/pnas.0605228103

PubMed ID: 17646174

Title: High-resolution crystal structure of beta2-microglobulin formed at pH 7.0.

PubMed ID: 17646174

DOI: 10.1093/jb/mvm148

PubMed ID: 18835253

Title: DE loop mutations affect beta2-microglobulin stability and amyloid aggregation.

PubMed ID: 18835253

DOI: 10.1016/j.bbrc.2008.09.108

PubMed ID: 18395224

Title: The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties.

PubMed ID: 18395224

DOI: 10.1016/j.jmb.2008.03.002

PubMed ID: 19284997

Title: Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation.

PubMed ID: 19284997

DOI: 10.1016/j.bbrc.2009.01.116

PubMed ID: 24695216

Title: T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

PubMed ID: 24695216

DOI: 10.1038/nature13160

PubMed ID: 16549777

Title: Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

PubMed ID: 16549777

DOI: 10.1073/pnas.0600548103

Sequence Information:

Length: 119
Mass: 13715
Checksum: AFD2DBEF07DCEF27
Sequence:

MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL 
KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: B2M

Associated with

Cells (max top 100)

Other Information

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. PubMed ID: 3312414

Cloning of human beta-microglobulin gene and its high expression in Escherichia coli. PubMed ID: 16108498

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon. PubMed ID: 11894933

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. PubMed ID: 6171820

The complete amino acid sequence of beta 2-microglobulin. PubMed ID: 4586824

Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. PubMed ID: 3532124

Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients. PubMed ID: 1336137

Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin. PubMed ID: 8084451

Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood. PubMed ID: 7554280

Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification. PubMed ID: 25946035

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. PubMed ID: 9427624

HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern. PubMed ID: 10605026

The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage. PubMed ID: 25356553

Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites. PubMed ID: 7918443

Initial characterization of the human central proteome. PubMed ID: 21269460

Hereditary systemic amyloidosis due to Asp76Asn variant beta2-microglobulin. PubMed ID: 22693999

Structure of the human class I histocompatibility antigen, HLA-A2. PubMed ID: 3309677

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution. PubMed ID: 2038058

1H NMR assignments and secondary structure of human beta 2-microglobulin in solution. PubMed ID: 1390678

The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain. PubMed ID: 7862664

Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. PubMed ID: 8624812

Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. PubMed ID: 12119416

A structural basis for immunodominant human T cell receptor recognition. PubMed ID: 12796775

Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis. PubMed ID: 16901902

A native to amyloidogenic transition regulated by a backbone trigger. PubMed ID: 16491088

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). PubMed ID: 17056715

High-resolution crystal structure of beta2-microglobulin formed at pH 7.0. PubMed ID: 17646174

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation. PubMed ID: 18835253

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties. PubMed ID: 18395224

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation. PubMed ID: 19284997

T-cell activation by transitory neo-antigens derived from distinct microbial pathways. PubMed ID: 24695216

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. PubMed ID: 16549777