B2M | ENSG00000166710 | NCBI 567

Details for: B2M

Gene ID: 567

Symbol: B2M

Ensembl ID: ENSG00000166710

Description: beta-2-microglobulin

Associated with

Adaptive immune system
(R-HSA-1280218)
Amyloid fiber formation
(R-HSA-977225)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Antigen processing-cross presentation
(R-HSA-1236975)
Bacterial infection pathways
(R-HSA-9824439)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Disease
(R-HSA-1643685)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Er-phagosome pathway
(R-HSA-1236974)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Modulation by mtb of host immune system
(R-HSA-9637628)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated downregulation of mhc class i complex cell surface expression
(R-HSA-164940)
Neutrophil degranulation
(R-HSA-6798695)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Viral infection pathways
(R-HSA-9824446)
Amyloid fibril formation
(GO:1990000)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Cellular response to iron(iii) ion
(GO:0071283)
Cellular response to iron ion
(GO:0071281)
Cellular response to nicotine
(GO:0071316)
Cytosol
(GO:0005829)
Early endosome lumen
(GO:0031905)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Er to golgi transport vesicle membrane
(GO:0012507)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion transport
(GO:0006826)
Late endosome membrane
(GO:0031902)
Learning or memory
(GO:0007611)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein complex
(GO:0042612)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of forebrain neuron differentiation
(GO:2000978)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of receptor binding
(GO:1900121)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide antigen binding
(GO:0042605)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of ferrous iron binding
(GO:1904434)
Positive regulation of immune response
(GO:0050778)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell cytokine production
(GO:0002726)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of transferrin receptor binding
(GO:1904437)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein refolding
(GO:0042026)
Recycling endosome membrane
(GO:0055038)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of iron ion transport
(GO:0034756)
Response to molecule of bacterial origin
(GO:0002237)
Sensory perception of smell
(GO:0007608)
Specific granule lumen
(GO:0035580)
Structural molecule activity
(GO:0005198)
T cell differentiation in thymus
(GO:0033077)
T cell mediated cytotoxicity
(GO:0001913)
Tertiary granule lumen
(GO:1904724)

Other Information

Proteins

Beta-2-microglobulin

Genular Protein ID: 2050760643

Symbol: B2MG_HUMAN

Name: Beta-2-microglobulin

UniProtKB Accession Codes:

P61769 P01884 Q540F8 Q6IAT8 Q9UCK0 Q9UD48 Q9UDF4

Database IDs:

Citations:

PubMed ID: 3312414

Title: The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

PubMed ID: 3312414

PubMed ID: 16108498

Title: Cloning of human beta-microglobulin gene and its high expression in Escherichia coli.

PubMed ID: 16108498

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11894933

Title: The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon.

PubMed ID: 11894933

DOI: 10.1002/j.1460-2075.1983.tb01412.x

PubMed ID: 6171820

Title: Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.

PubMed ID: 6171820

DOI: 10.1073/pnas.78.11.6613

PubMed ID: 4586824

Title: The complete amino acid sequence of beta 2-microglobulin.

PubMed ID: 4586824

DOI: 10.1021/bi00748a001

PubMed ID: 3532124

Title: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis.

PubMed ID: 3532124

DOI: 10.1073/pnas.83.20.7908

PubMed ID: 1336137

Title: Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients.

PubMed ID: 1336137

PubMed ID: 8084451

Title: Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin.

PubMed ID: 8084451

PubMed ID: 7554280

Title: Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood.

PubMed ID: 7554280

DOI: 10.1016/0009-8981(95)06039-g

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 25356553

Title: The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage.

PubMed ID: 25356553

DOI: 10.1371/journal.ppat.1004446

PubMed ID: 7918443

Title: Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites.

PubMed ID: 7918443

DOI: 10.1021/bi00206a026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22693999

Title: Hereditary systemic amyloidosis due to Asp76Asn variant beta2-microglobulin.

PubMed ID: 22693999

DOI: 10.1056/nejmoa1201356

PubMed ID: 3309677

Title: Structure of the human class I histocompatibility antigen, HLA-A2.

PubMed ID: 3309677

DOI: 10.1038/329506a0

PubMed ID: 2038058

Title: Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution.

PubMed ID: 2038058

DOI: 10.1016/0022-2836(91)90567-p

PubMed ID: 1390678

Title: 1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.

PubMed ID: 1390678

DOI: 10.1021/bi00152a030

PubMed ID: 7862664

Title: The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.

PubMed ID: 7862664

DOI: 10.1073/pnas.92.4.1218

PubMed ID: 8624812

Title: Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.

PubMed ID: 8624812

DOI: 10.1016/s1074-7613(00)80430-6

PubMed ID: 12119416

Title: Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.

PubMed ID: 12119416

DOI: 10.1073/pnas.152337399

PubMed ID: 12796775

Title: A structural basis for immunodominant human T cell receptor recognition.

PubMed ID: 12796775

DOI: 10.1038/ni942

PubMed ID: 16901902

Title: Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis.

PubMed ID: 16901902

DOI: 10.1074/jbc.m605358200

PubMed ID: 16491088

Title: A native to amyloidogenic transition regulated by a backbone trigger.

PubMed ID: 16491088

DOI: 10.1038/nsmb1068

PubMed ID: 17056715

Title: Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).

PubMed ID: 17056715

DOI: 10.1073/pnas.0605228103

PubMed ID: 17646174

Title: High-resolution crystal structure of beta2-microglobulin formed at pH 7.0.

PubMed ID: 17646174

DOI: 10.1093/jb/mvm148

PubMed ID: 18835253

Title: DE loop mutations affect beta2-microglobulin stability and amyloid aggregation.

PubMed ID: 18835253

DOI: 10.1016/j.bbrc.2008.09.108

PubMed ID: 18395224

Title: The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties.

PubMed ID: 18395224

DOI: 10.1016/j.jmb.2008.03.002

PubMed ID: 19284997

Title: Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation.

PubMed ID: 19284997

DOI: 10.1016/j.bbrc.2009.01.116

PubMed ID: 24695216

Title: T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

PubMed ID: 24695216

DOI: 10.1038/nature13160

PubMed ID: 16549777

Title: Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

PubMed ID: 16549777

DOI: 10.1073/pnas.0600548103

Sequence Information:

Length: 119
Mass: 13715
Checksum: AFD2DBEF07DCEF27
Sequence:

MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL 
KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: B2M

Associated with

Other Information

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. PubMed ID: 3312414

Cloning of human beta-microglobulin gene and its high expression in Escherichia coli. PubMed ID: 16108498

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon. PubMed ID: 11894933

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. PubMed ID: 6171820

The complete amino acid sequence of beta 2-microglobulin. PubMed ID: 4586824

Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. PubMed ID: 3532124

Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients. PubMed ID: 1336137

Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin. PubMed ID: 8084451

Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood. PubMed ID: 7554280

Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification. PubMed ID: 25946035

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. PubMed ID: 9427624

HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern. PubMed ID: 10605026

The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage. PubMed ID: 25356553

Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites. PubMed ID: 7918443

Initial characterization of the human central proteome. PubMed ID: 21269460

Hereditary systemic amyloidosis due to Asp76Asn variant beta2-microglobulin. PubMed ID: 22693999

Structure of the human class I histocompatibility antigen, HLA-A2. PubMed ID: 3309677

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution. PubMed ID: 2038058

1H NMR assignments and secondary structure of human beta 2-microglobulin in solution. PubMed ID: 1390678

The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain. PubMed ID: 7862664

Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. PubMed ID: 8624812

Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. PubMed ID: 12119416

A structural basis for immunodominant human T cell receptor recognition. PubMed ID: 12796775

Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis. PubMed ID: 16901902

A native to amyloidogenic transition regulated by a backbone trigger. PubMed ID: 16491088

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). PubMed ID: 17056715

High-resolution crystal structure of beta2-microglobulin formed at pH 7.0. PubMed ID: 17646174

DE loop mutations affect beta2-microglobulin stability and amyloid aggregation. PubMed ID: 18835253

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties. PubMed ID: 18395224

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation. PubMed ID: 19284997

T-cell activation by transitory neo-antigens derived from distinct microbial pathways. PubMed ID: 24695216

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. PubMed ID: 16549777