Mtor | ENSMUSG00000028991 | NCBI 56717

Details for: Mtor

Gene ID: 56717

Symbol: Mtor

Ensembl ID: ENSMUSG00000028991

Description: mechanistic target of rapamycin kinase

Associated with

Adaptive immune system
(R-MMU-1280218)
Amino acids regulate mtorc1
(R-MMU-9639288)
Autophagy
(R-MMU-9612973)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Costimulation by the cd28 family
(R-MMU-388841)
Energy dependent regulation of mtor by lkb1-ampk
(R-MMU-380972)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hsf1-dependent transactivation
(R-MMU-3371571)
Immune system
(R-MMU-168256)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mtorc1-mediated signalling
(R-MMU-166208)
Mtor signalling
(R-MMU-165159)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten gene transcription
(R-MMU-8943724)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
'de novo' pyrimidine nucleobase biosynthetic process
(GO:0006207)
Atp binding
(GO:0005524)
Cellular response to starvation
(GO:0009267)
Cytoskeleton organization
(GO:0007010)
Dna damage response
(GO:0006974)
Energy reserve metabolic process
(GO:0006112)
Germ cell development
(GO:0007281)
Heart morphogenesis
(GO:0003007)
Heart valve morphogenesis
(GO:0003179)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Kinase activity
(GO:0016301)
Long-term memory
(GO:0007616)
Lysosome organization
(GO:0007040)
Macroautophagy
(GO:0016236)
Metal ion binding
(GO:0046872)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of macroautophagy
(GO:0016242)
Negative regulation of muscle atrophy
(GO:0014736)
Negative regulation of protein phosphorylation
(GO:0001933)
Neuronal action potential
(GO:0019228)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphoprotein binding
(GO:0051219)
Phosphorylation
(GO:0016310)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of myotube differentiation
(GO:0010831)
Positive regulation of neuron maturation
(GO:0014042)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein phosphorylation
(GO:0001934)
Post-embryonic development
(GO:0009791)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of autophagy
(GO:0010506)
Regulation of carbohydrate metabolic process
(GO:0006109)
Regulation of cell growth
(GO:0001558)
Regulation of cell size
(GO:0008361)
Regulation of glycogen biosynthetic process
(GO:0005979)
Regulation of protein phosphorylation
(GO:0001932)
Response to heat
(GO:0009408)
Response to nutrient
(GO:0007584)
Ribosome binding
(GO:0043022)
Rna polymerase iii type 1 promoter sequence-specific dna binding
(GO:0001002)
Rna polymerase iii type 2 promoter sequence-specific dna binding
(GO:0001003)
Rna polymerase iii type 3 promoter sequence-specific dna binding
(GO:0001006)
T-helper 1 cell lineage commitment
(GO:0002296)
Tfiiic-class transcription factor complex binding
(GO:0001156)
Transferase activity
(GO:0016740)
Visual learning
(GO:0008542)

Other Information

Proteins

FK506-binding protein 12-rapamycin complex-associated protein 1

Genular Protein ID: 207369941

Symbol: MTOR_MOUSE

Name: FK506-binding protein 12-rapamycin complex-associated protein 1

UniProtKB Accession Codes:

Q9JLN9 Q2KHT0 Q811J5 Q9CST1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7809080

Title: RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

PubMed ID: 7809080

DOI: 10.1073/pnas.91.26.12574

PubMed ID: 11792863

Title: Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.

PubMed ID: 11792863

DOI: 10.1073/pnas.022634399

PubMed ID: 11930000

Title: FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction.

PubMed ID: 11930000

DOI: 10.1073/pnas.261702698

PubMed ID: 15545625

Title: Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

PubMed ID: 15545625

DOI: 10.1101/gad.1256804

PubMed ID: 15485918

Title: Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.

PubMed ID: 15485918

DOI: 10.1128/mcb.24.21.9508-9516.2004

PubMed ID: 15467718

Title: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

PubMed ID: 15467718

DOI: 10.1038/ncb1183

PubMed ID: 16221682

Title: mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.

PubMed ID: 16221682

DOI: 10.1074/jbc.m508361200

PubMed ID: 16962653

Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

PubMed ID: 16962653

DOI: 10.1016/j.cell.2006.08.033

PubMed ID: 16915281

Title: PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.

PubMed ID: 16915281

DOI: 10.1038/nature05029

PubMed ID: 18046414

Title: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

PubMed ID: 18046414

DOI: 10.1038/nature06322

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19440205

Title: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.

PubMed ID: 19440205

DOI: 10.1038/emboj.2009.127

PubMed ID: 19346248

Title: Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

PubMed ID: 19346248

DOI: 10.1074/jbc.c109.002907

PubMed ID: 19487463

Title: Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

PubMed ID: 19487463

DOI: 10.1128/mcb.01665-08

PubMed ID: 19704009

Title: Regulation of myoblast differentiation by the nuclear envelope protein NET39.

PubMed ID: 19704009

DOI: 10.1128/mcb.00684-09

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 21258367

Title: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

PubMed ID: 21258367

DOI: 10.1038/ncb2152

PubMed ID: 21659604

Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

PubMed ID: 21659604

DOI: 10.1126/science.1199498

PubMed ID: 23027611

Title: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

PubMed ID: 23027611

DOI: 10.1002/emmm.201201410

PubMed ID: 24187137

Title: Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver.

PubMed ID: 24187137

DOI: 10.1074/jbc.m113.500736

PubMed ID: 26359501

Title: Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.

PubMed ID: 26359501

DOI: 10.1074/jbc.m115.678433

PubMed ID: 24011591

Title: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

PubMed ID: 24011591

DOI: 10.1016/j.molcel.2013.08.003

PubMed ID: 27913603

Title: The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

PubMed ID: 27913603

DOI: 10.1101/gad.287953.116

PubMed ID: 29750810

Title: mTOR signaling regulates central and peripheral circadian clock function.

PubMed ID: 29750810

DOI: 10.1371/journal.pgen.1007369

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

PubMed ID: 29150432

Title: The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

PubMed ID: 29150432

DOI: 10.15252/embj.201696164

PubMed ID: 34289345

Title: Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

PubMed ID: 34289345

DOI: 10.1016/j.cell.2021.06.028

Sequence Information:

Length: 2549
Mass: 288789
Checksum: 56302E5171FB6DBD
Sequence:

MLGTGPAVAT ASAATSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 
TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN STRIGRFANY LRNLLPSSDP 
VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP 
TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 
AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 
KDLMGFGTKP RHITPFTSFQ AVQPQQPNAL VGLLGYSSPQ GLMGFGTSPS PAKSTLVESR 
CCRDLMEEKF DQVCQWVLKC RSSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 
LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKTVQVDA 
TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 
KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVA SITLALRTLG SFEFEGHSLT 
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL 
VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 
MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 
LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA 
LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 
DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 
SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 
VFMHDNSQGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEVPLP SRKAALETVD 
RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV 
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSS QGDALASGPV ETGPMKKLHV 
STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 
AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 
VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAS GVLEYAMKHF 
GELEIQATWY EKLHEWEDAL VAYDKKMDTN KEDPELMLGR MRCLEALGEW GQLHQQCCEK 
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 
QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW 
ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD 
PSRQLDHPLP TAHPQVTYAY MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK 
QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA 
VLHYKHQNQA RDEKKKLRHA SGANITNATT AATTAASAAA ATSTEGSNSE SEAESNENSP 
TPSPLQKKVT EDLSKTLLLY TVPAVQGFFR SISLSRGNNL QDTLRVLTLW FDYGHWPDVN 
EALVEGVKAI QIDTWLQVIP QLIARIDTPR PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS 
KSTTTARHNA ANKILKNMCE HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG 
ERNVKGMFEV LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA 
WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI IRIQSIAPSL 
QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ LFGLVNTLLA NDPTSLRKNL 
SIQRYAVIPL STNSGLIGWV PHCDTLHALI RDYREKKKIL LNIEHRIMLR MAPDYDHLTL 
MQKVEVFEHA VNNTAGDDLA KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH 
PSNLMLDRLS GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRTTC 
HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYS AGQSVEILDG 
VELGEPAHKK AGTTVPESIH SFIGDGLVKP EALNKKAIQI INRVRDKLTG RDFSHDDTLD 
VPTQVELLIK QATSHENLCQ CYIGWCPFW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mtor

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. PubMed ID: 7809080

Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. PubMed ID: 11792863

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. PubMed ID: 11930000

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. PubMed ID: 15545625

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. PubMed ID: 15485918

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. PubMed ID: 15467718

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. PubMed ID: 16221682

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. PubMed ID: 16962653

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. PubMed ID: 16915281

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. PubMed ID: 18046414

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. PubMed ID: 19440205

Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. PubMed ID: 19346248

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. PubMed ID: 19487463

Regulation of myoblast differentiation by the nuclear envelope protein NET39. PubMed ID: 19704009

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. PubMed ID: 20801936

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. PubMed ID: 21258367

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. PubMed ID: 21659604

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. PubMed ID: 23027611

Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. PubMed ID: 24187137

Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. PubMed ID: 26359501

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. PubMed ID: 24011591

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. PubMed ID: 27913603

mTOR signaling regulates central and peripheral circadian clock function. PubMed ID: 29750810

Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens. PubMed ID: 31786107

The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists. PubMed ID: 29150432

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. PubMed ID: 34289345