Prkn | ENSRNOG00000055547 | NCBI 56816

Details for: Prkn

Gene ID: 56816

Symbol: Prkn

Ensembl ID: ENSRNOG00000055547

Description: parkin RBR E3 ubiquitin protein ligase

Associated with

Adaptive immune system
(R-RNO-1280218)
Aggrephagy
(R-RNO-9646399)
Antigen processing: ubiquitination & proteasome degradation
(R-RNO-983168)
Class i mhc mediated antigen processing & presentation
(R-RNO-983169)
Deubiquitination
(R-RNO-5688426)
Immune system
(R-RNO-168256)
Josephin domain dubs
(R-RNO-5689877)
Macroautophagy
(R-RNO-1632852)
Metabolism of proteins
(R-RNO-392499)
Pink1-prkn mediated mitophagy
(R-RNO-5205685)
Post-translational protein modification
(R-RNO-597592)
Programmed cell death
(R-RNO-5357801)
Regulated necrosis
(R-RNO-5218859)
Regulation of necroptotic cell death
(R-RNO-5675482)
Ripk1-mediated regulated necrosis
(R-RNO-5213460)
Selective autophagy
(R-RNO-9663891)
Actin binding
(GO:0003779)
Adult locomotory behavior
(GO:0008344)
Autophagy
(GO:0006914)
Autophagy of mitochondrion
(GO:0000422)
Beta-catenin binding
(GO:0008013)
Catabolic process
(GO:0009056)
Cellular response to oxidative stress
(GO:0034599)
Cullin family protein binding
(GO:0097602)
Dopamine metabolic process
(GO:0042417)
Enzyme binding
(GO:0019899)
F-box domain binding
(GO:1990444)
Free ubiquitin chain polymerization
(GO:0010994)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Histone deacetylase binding
(GO:0042826)
Hsp70 protein binding
(GO:0030544)
Identical protein binding
(GO:0042802)
Kinase binding
(GO:0019900)
Learning
(GO:0007612)
Locomotory behavior
(GO:0007626)
Mitochondrial fission
(GO:0000266)
Mitochondrion organization
(GO:0007005)
Mitophagy
(GO:0000423)
Negative regulation of actin filament bundle assembly
(GO:0032232)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of mitochondrial fusion
(GO:0010637)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Norepinephrine metabolic process
(GO:0042415)
Pdz domain binding
(GO:0030165)
Phospholipase binding
(GO:0043274)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of mitochondrial fusion
(GO:0010636)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Proteasomal protein catabolic process
(GO:0010498)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein destabilization
(GO:0031648)
Protein kinase binding
(GO:0019901)
Protein metabolic process
(GO:0019538)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Regulation of apoptotic process
(GO:0042981)
Regulation of autophagy
(GO:0010506)
Regulation of dopamine metabolic process
(GO:0042053)
Regulation of mitochondrion organization
(GO:0010821)
Regulation of protein stability
(GO:0031647)
Regulation of protein ubiquitination
(GO:0031396)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to muscle activity
(GO:0014850)
Response to oxidative stress
(GO:0006979)
Response to unfolded protein
(GO:0006986)
Response to xenobiotic stimulus
(GO:0009410)
Startle response
(GO:0001964)
Synaptic transmission, dopaminergic
(GO:0001963)
Synaptic transmission, glutamatergic
(GO:0035249)
Transcription corepressor activity
(GO:0003714)
Tubulin binding
(GO:0015631)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-specific protease binding
(GO:1990381)
Ubiquitin binding
(GO:0043130)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

PRKN_RAT

Genular Protein ID: 1331267978

Symbol: PRKN_RAT

Name: N/A

UniProtKB Accession Codes:

Q9JK66 Q8K5C3 Q8K5C4 Q8K5C5 Q8K5C6 Q8VHY6 Q9JLL1 Q9JM64

Database IDs:

Citations:

PubMed ID: 10686358

Title: Cloning and distribution of the rat parkin mRNA.

PubMed ID: 10686358

DOI: 10.1016/s0169-328x(99)00286-7

PubMed ID: 10737637

Title: Cloning of rat parkin cDNA and distribution of parkin in rat brain.

PubMed ID: 10737637

DOI: 10.1046/j.1471-4159.2000.0741773.x

PubMed ID: 12925569

Title: The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.

PubMed ID: 12925569

DOI: 10.1093/hmg/ddg269

PubMed ID: 16955485

Title: Functional modulation of parkin through physical interaction with SUMO-1.

PubMed ID: 16955485

DOI: 10.1002/jnr.21041

PubMed ID: 23661642

Title: Structure of parkin reveals mechanisms for ubiquitin ligase activation.

PubMed ID: 23661642

DOI: 10.1126/science.1237908

Sequence Information:

Length: 465
Mass: 51709
Checksum: E13CF170AD6D042B
Sequence:

MIVFVRFNSS YGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL QNHLTVQNCD 
LEQQSIVHIV QRPQRKSHET NASGGDKPQS TPEGSIWEPR SLTRVDLSSH ILPADSVGLA 
VILDTDSKSD SEAARGPEAK PTYHSFFVYC KGPCHKVQPG KLRVQCGTCR QATLTLAQGP 
SCWDDVLIPN RMSGECQSPD CPGTRAEFFF KCGAHPTSDK DTSVALNLIT NNSRSIPCIA 
CTDVRNPVLV FQCNHRHVIC LDCFHLYCVT RLNDRQFVHD AQLGYSLPCV AGCPNSLIKE 
LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEQGQKKV TCEGGNGLGC 
GFVFCRDCKE AYHEGECDSM FEASGATSQA YRVDQRAAEQ ARWEEASKET IKKTTKPCPR 
CNVPIEKNGG CMHMKCPQPQ CKLEWCWNCG CEWNRACMGD HWFDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkn

Associated with

Other Information

Cloning and distribution of the rat parkin mRNA. PubMed ID: 10686358

Cloning of rat parkin cDNA and distribution of parkin in rat brain. PubMed ID: 10737637

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. PubMed ID: 12925569