Details for: SPHK2

Gene ID: 56848

Symbol: SPHK2

Ensembl ID: ENSG00000063176

Description: sphingosine kinase 2

Associated with

Other Information

Genular Protein ID: 3330957295

Symbol: SPHK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10751414

Title: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.

PubMed ID: 10751414

DOI: 10.1074/jbc.m002759200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12954646

Title: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis.

PubMed ID: 12954646

DOI: 10.1074/jbc.m306577200

PubMed ID: 16103110

Title: Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.

PubMed ID: 16103110

DOI: 10.1074/jbc.m504507200

PubMed ID: 16118219

Title: SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

PubMed ID: 16118219

DOI: 10.1074/jbc.m502207200

PubMed ID: 17311928

Title: Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.

PubMed ID: 17311928

DOI: 10.1074/jbc.m609559200

PubMed ID: 17635916

Title: Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

PubMed ID: 17635916

DOI: 10.1074/jbc.m701641200

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18263879

Title: Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

PubMed ID: 18263879

DOI: 10.1074/jbc.m708782200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168031

Title: A lipid binding domain in sphingosine kinase 2.

PubMed ID: 19168031

DOI: 10.1016/j.bbrc.2009.01.075

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 20197547

Title: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

PubMed ID: 20197547

DOI: 10.1182/blood-2009-10-243444

PubMed ID: 20959514

Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

PubMed ID: 20959514

DOI: 10.1096/fj.10-167502

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29615132

Title: Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.

PubMed ID: 29615132

DOI: 10.1186/s40478-018-0527-z

Sequence Information:

  • Length: 654
  • Mass: 69217
  • Checksum: F73FFCEC930DA50F
  • Sequence:
  • MNGHLEAEEQ QDQRPDQELT GSWGHGPRST LVRAKAMAPP PPPLAASTPL LHGEFGSYPA 
    RGPRFALTLT SQALHIQRLR PKPEARPRGG LVPLAEVSGC CTLRSRSPSD SAAYFCIYTY 
    PRGRRGARRR ATRTFRADGA ATYEENRAEA QRWATALTCL LRGLPLPGDG EITPDLLPRP 
    PRLLLLVNPF GGRGLAWQWC KNHVLPMISE AGLSFNLIQT ERQNHARELV QGLSLSEWDG 
    IVTVSGDGLL HEVLNGLLDR PDWEEAVKMP VGILPCGSGN ALAGAVNQHG GFEPALGLDL 
    LLNCSLLLCR GGGHPLDLLS VTLASGSRCF SFLSVAWGFV SDVDIQSERF RALGSARFTL 
    GTVLGLATLH TYRGRLSYLP ATVEPASPTP AHSLPRAKSE LTLTPDPAPP MAHSPLHRSV 
    SDLPLPLPQP ALASPGSPEP LPILSLNGGG PELAGDWGGA GDAPLSPDPL LSSPPGSPKA 
    ALHSPVSEGA PVIPPSSGLP LPTPDARVGA STCGPPDHLL PPLGTPLPPD WVTLEGDFVL 
    MLAISPSHLG ADLVAAPHAR FDDGLVHLCW VRSGISRAAL LRLFLAMERG SHFSLGCPQL 
    GYAAARAFRL EPLTPRGVLT VDGEQVEYGP LQAQMHPGIG TLLTGPPGCP GREP

Genular Protein ID: 873394092

Symbol: B3KV83_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 627
  • Mass: 66398
  • Checksum: E9B24E7034078F3A
  • Sequence:
  • MNGHLEAEEQ QDQRPDQELT GSWGHGPRST LVRAKAMAPP PPPLAASTPL LHGEFGSYPA 
    RGPRFALTLT SQALHIQRLR PSDSAAYFCI YTYPRGRRGA RRRATRTFRA DGAATYEENR 
    AEAQRWATAL TCLLRGLPLP GDGEITPDLL PRPPRLLLLV NPFGGRGLAW QWCKNHVLPM 
    ISEAGLSFNL IQTERQNHAR ELVQGLSLSE WDGIVTVSGD GLLHEVLNGL LDRPDWEEAV 
    KMPVGILPCG SGNALAGAVN QHGGFEPALG LDLLLNCSLL LCRGGGHPLD LLSVTLASGS 
    RCFSFLSVAW GFVSDVDIQS ERFRALGSAR FTLGTVLGLA TLHTYRGRLS YLPATVEPAS 
    PTPAHSLPRA KSELTLTPDP APPMAHSPLH RSVSDLPLPL PQPALASPGS PEPLPILSLN 
    GGGPELAGDW GGAGDAPLSP DPLLSSPPGS PKAALHSPVS EGAPVIPPSS GLPLPTPDAR 
    VGASTCGPPD HLLPPLGTPL PPDWVTLEGD FVLMLAISPS HLGADLVAAP HARFDDGLVH 
    LCWVRSGISR AALLRLFLAM ERGSHFSLGC PQLGYAAARA FRLEPLTPRG VLTVDGEQVE 
    YGPLQAQMHP GIGTLLTGPP GCPGREP

Genular Protein ID: 1968982660

Symbol: E9PCV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 448
  • Mass: 46563
  • Checksum: 9823B293362626FB
  • Sequence:
  • MISEAGLSFN LIQTERQNHA RELVQGLSLS EWDGIVTVSG DGLLHEVLNG LLDRPDWEEA 
    VKMPVGILPC GSGNALAGAV NQHGGFEPAL GLDLLLNCSL LLCRGGGHPL DLLSVTLASG 
    SRCFSFLSVA WGFVSDVDIQ SERFRALGSA RFTLGTVLGL ATLHTYRGRL SYLPATVEPA 
    SPTPAHSLPR AKSELTLTPD PAPPMAHSPL HRSVSDLPLP LPQPALASPG SPEPLPILSL 
    NGGGPELAGD WGGAGDAPLS PDPLLSSPPG SPKAALHSPV SEGAPVIPPS SGLPLPTPDA 
    RVGASTCGPP DHLLPPLGTP LPPDWVTLEG DFVLMLAISP SHLGADLVAA PHARFDDGLV 
    HLCWVRSGIS RAALLRLFLA MERGSHFSLG CPQLGYAAAR AFRLEPLTPR GVLTVDGEQV 
    EYGPLQAQMH PGIGTLLTGP PGCPGREP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.