Details for: EMC7

Gene ID: 56851

Symbol: EMC7

Ensembl ID: ENSG00000134153

Description: ER membrane protein complex subunit 7

Associated with

Other Information

Genular Protein ID: 1425785227

Symbol: EMC7_HUMAN

Name: ER membrane protein complex subunit 7

UniProtKB Accession Codes:

Q9NPA0 B2RC00 Q96ED5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873569

Title: Characterization of five novel human genes in the 11q13-q22 region.

PubMed ID: 10873569

DOI: 10.1006/bbrc.2000.2910

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22119785

Title: Defining human ERAD networks through an integrative mapping strategy.

PubMed ID: 22119785

DOI: 10.1038/ncb2383

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17825839

Title: Single MHC mutation eliminates enthalpy associated with T cell receptor binding.

PubMed ID: 17825839

DOI: 10.1016/j.jmb.2007.07.028

PubMed ID: 30415835

Title: EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

PubMed ID: 30415835

DOI: 10.1016/j.cell.2018.10.009

PubMed ID: 29809151

Title: The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

PubMed ID: 29809151

DOI: 10.7554/elife.37018

PubMed ID: 29242231

Title: The ER membrane protein complex is a transmembrane domain insertase.

PubMed ID: 29242231

DOI: 10.1126/science.aao3099

PubMed ID: 32459176

Title: The architecture of EMC reveals a path for membrane protein insertion.

PubMed ID: 32459176

DOI: 10.7554/elife.57887

PubMed ID: 32439656

Title: Structural basis for membrane insertion by the human ER membrane protein complex.

PubMed ID: 32439656

DOI: 10.1126/science.abb5008

Sequence Information:

  • Length: 242
  • Mass: 26471
  • Checksum: A71930B89A4C2458
  • Sequence:
    • MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD 
WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA 
RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP 
KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK 
RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.