EXOSC5 | ENSG00000077348 | NCBI 56915

Details for: EXOSC5

Gene ID: 56915

Symbol: EXOSC5

Ensembl ID: ENSG00000077348

Description: exosome component 5

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Deadenylation-dependent mrna decay
(R-HSA-429914)
Ksrp (khsrp) binds and destabilizes mrna
(R-HSA-450604)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Mrna decay by 3' to 5' exoribonuclease
(R-HSA-429958)
Perk regulates gene expression
(R-HSA-381042)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
Unfolded protein response (upr)
(R-HSA-381119)
3'-5'-rna exonuclease activity
(GO:0000175)
Cytoplasm
(GO:0005737)
Cytoplasmic exosome (rnase complex)
(GO:0000177)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna binding
(GO:0003677)
Dna deamination
(GO:0045006)
Euchromatin
(GO:0000791)
Exonucleolytic catabolism of deadenylated mrna
(GO:0043928)
Exosome (rnase complex)
(GO:0000178)
Nuclear-transcribed mrna catabolic process, exonucleolytic, 3'-5'
(GO:0034427)
Nuclear exosome (rnase complex)
(GO:0000176)
Nuclear mrna surveillance
(GO:0071028)
Nucleolar exosome (rnase complex)
(GO:0101019)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Polyadenylation-dependent snorna 3'-end processing
(GO:0071051)
Protein binding
(GO:0005515)
Rna catabolic process
(GO:0006401)
Rna exonuclease activity
(GO:0004532)
Rna processing
(GO:0006396)
Rrna catabolic process
(GO:0016075)
Rrna processing
(GO:0006364)
U4 snrna 3'-end processing
(GO:0034475)

Other Information

Proteins

Exosome complex component RRP46

Genular Protein ID: 4115544395

Symbol: EXOS5_HUMAN

Name: Exosome complex component RRP46

UniProtKB Accession Codes:

Q9NQT4 Q32Q81 Q8NG16 Q96I89

Database IDs:

Citations:

PubMed ID: 11110791

Title: Three novel components of the human exosome.

PubMed ID: 11110791

DOI: 10.1074/jbc.m007603200

PubMed ID: 12359762

Title: CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells.

PubMed ID: 12359762

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10465791

Title: The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases.

PubMed ID: 10465791

DOI: 10.1101/gad.13.16.2148

PubMed ID: 11719186

Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

PubMed ID: 11719186

DOI: 10.1016/s0092-8674(01)00578-5

PubMed ID: 11782436

Title: The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.

PubMed ID: 11782436

DOI: 10.1093/emboj/21.1.165

PubMed ID: 11812149

Title: Protein-protein interactions of hCsl4p with other human exosome subunits.

PubMed ID: 11812149

DOI: 10.1006/jmbi.2001.5265

PubMed ID: 17185417

Title: The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA.

PubMed ID: 17185417

DOI: 10.1073/pnas.0607063104

PubMed ID: 18334637

Title: p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein.

PubMed ID: 18334637

DOI: 10.1073/pnas.0712276105

PubMed ID: 20531389

Title: Dis3-like 1: a novel exoribonuclease associated with the human exosome.

PubMed ID: 20531389

DOI: 10.1038/emboj.2010.122

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21255825

Title: The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

PubMed ID: 21255825

DOI: 10.1016/j.cell.2011.01.001

PubMed ID: 21515746

Title: Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs.

PubMed ID: 21515746

DOI: 10.1096/fj.10-178715

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17174896

Title: Reconstitution, activities, and structure of the eukaryotic RNA exosome.

PubMed ID: 17174896

DOI: 10.1016/j.cell.2006.10.037

PubMed ID: 20660080

Title: Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation.

PubMed ID: 20660080

DOI: 10.1261/rna.2180810

PubMed ID: 29906447

Title: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.

PubMed ID: 29906447

DOI: 10.1016/j.cell.2018.05.041

PubMed ID: 30950035

Title: Identification of disease-causing variants in the EXOSC gene family underlying autosomal recessive intellectual disability in Iranian families.

PubMed ID: 30950035

DOI: 10.1111/cge.13549

PubMed ID: 32504085

Title: Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness.

PubMed ID: 32504085

DOI: 10.1093/hmg/ddaa108

PubMed ID: 34089229

Title: Risk of sudden cardiac death in EXOSC5-related disease.

PubMed ID: 34089229

DOI: 10.1002/ajmg.a.62352

Sequence Information:

Length: 235
Mass: 25249
Checksum: C3C1FCB39D85B1EE
Sequence:

MEEETHTDAK IRAENGTGSS PRGPGCSLRH FACEQNLLSR PDGSASFLQG DTSVLAGVYG 
PAEVKVSKEI FNKATLEVIL RPKIGLPGVA EKSRERLIRN TCEAVVLGTL HPRTSITVVL 
QVVSDAGSLL ACCLNAACMA LVDAGVPMRA LFCGVACALD SDGTLVLDPT SKQEKEARAV 
LTFALDSVER KLLMSSTKGL YSDTELQQCL AAAQAASQHV FRFYRESLQR RYSKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EXOSC5

Associated with

Other Information

Three novel components of the human exosome. PubMed ID: 11110791

CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells. PubMed ID: 12359762

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The yeast exosome and human PM-Scl are related complexes of 3'--&gt;5' exonucleases. PubMed ID: 10465791

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. PubMed ID: 11719186

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. PubMed ID: 11782436

Protein-protein interactions of hCsl4p with other human exosome subunits. PubMed ID: 11812149

The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. PubMed ID: 17185417

p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. PubMed ID: 18334637

Dis3-like 1: a novel exoribonuclease associated with the human exosome. PubMed ID: 20531389

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. PubMed ID: 21255825

Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs. PubMed ID: 21515746

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Reconstitution, activities, and structure of the eukaryotic RNA exosome. PubMed ID: 17174896

Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation. PubMed ID: 20660080

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. PubMed ID: 29906447

Identification of disease-causing variants in the EXOSC gene family underlying autosomal recessive intellectual disability in Iranian families. PubMed ID: 30950035

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness. PubMed ID: 32504085

Risk of sudden cardiac death in EXOSC5-related disease. PubMed ID: 34089229