Details for: FEM1C

Gene ID: 56929

Symbol: FEM1C

Ensembl ID: ENSG00000145780

Description: fem-1 homolog C

Associated with

Other Information

Genular Protein ID: 446551078

Symbol: FEM1C_HUMAN

Name: FEM1-gamma

UniProtKB Accession Codes:

Q96JP0 B2RE47 Q8N3V8 Q9H704 Q9NPL6 Q9NPL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 9 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11733146

Title: Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene.

PubMed ID: 11733146

DOI: 10.1016/s0378-1119(01)00756-9

PubMed ID: 14527725

Title: The Fem1c genes: conserved members of the Fem1 gene family in vertebrates.

PubMed ID: 14527725

DOI: 10.1016/s0378-1119(03)00712-1

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

PubMed ID: 28118078

Title: FEM1 proteins are ancient regulators of SLBP degradation.

PubMed ID: 28118078

DOI: 10.1080/15384101.2017.1284715

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 29775578

Title: C-terminal end-directed protein elimination by CRL2 ubiquitin ligases.

PubMed ID: 29775578

DOI: 10.1016/j.molcel.2018.04.006

PubMed ID: 33398168

Title: Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase.

PubMed ID: 33398168

DOI: 10.1038/s41589-020-00704-3

PubMed ID: 33398170

Title: Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.

PubMed ID: 33398170

DOI: 10.1038/s41589-020-00703-4

PubMed ID: 36336956

Title: A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia.

PubMed ID: 36336956

DOI: 10.1093/hmg/ddac276

Sequence Information:

  • Length: 617
  • Mass: 68673
  • Checksum: 6218B3963C486369
  • Sequence:
    • MDLKTAVFNA ARDGKLRLLT KLLASKSKEE VSSLISEKTN GATPLLMAAR YGHLDMVEFL 
LEQCSASIEV GGSVNFDGET IEGAPPLWAA SAAGHLKVVQ SLLNHGASVN NTTLTNSTPL 
RAACFDGHLE IVKYLVEHKA DLEVSNRHGH TCLMISCYKG HKEIAQYLLE KGADVNRKSV 
KGNTALHDCA ESGSLDIMKM LLMYCAKMEK DGYGMTPLLS ASVTGHTNIV DFLTHHAQTS 
KTERINALEL LGATFVDKKR DLLGALKYWK KAMNMRYSDR TNIISKPVPQ TLIMAYDYAK 
EVNSAEELEG LIADPDEMRM QALLIRERIL GPSHPDTSYY IRYRGAVYAD SGNFKRCINL 
WKYALDMQQS NLDPLSPMTA SSLLSFAELF SFMLQDRAKG LLGTTVTFDD LMGILCKSVL 
EIERAIKQTQ CPADPLQLNK ALSIILHLIC LLEKVPCTLE QDHFKKQTIY RFLKLHPRGK 
NNFSPLHLAV DKNTTCVGRY PVCKFPSLQV TAILIECGAD VNVRDSDDNS PLHIAALNNH 
PDIMNLLIKS GAHFDATNLH KQTASDLLDE KEIAKNLIQP INHTTLQCLA ARVIVNHRIY 
YKGHIPEKLE TFVSLHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.