PMEPA1 | ENSG00000124225 | NCBI 56937

Details for: PMEPA1

Gene ID: 56937

Symbol: PMEPA1

Ensembl ID: ENSG00000124225

Description: prostate transmembrane protein, androgen induced 1

Associated with

Downregulation of tgf-beta receptor signaling
(R-HSA-2173788)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Androgen receptor signaling pathway
(GO:0030521)
Early endosome membrane
(GO:0031901)
Endosome membrane
(GO:0010008)
Golgi membrane
(GO:0000139)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein sequestering activity
(GO:0140311)
R-smad binding
(GO:0070412)
Ww domain binding
(GO:0050699)

Other Information

Proteins

Protein TMEPAI
Q5JY37_HUMAN

Genular Protein ID: 1901894944

Symbol: PMEPA_HUMAN

Name: Protein TMEPAI

UniProtKB Accession Codes:

Q969W9 Q5TDR6 Q8NER4 Q96B72 Q9UJD3

Database IDs:

Citations:

PubMed ID: 10873380

Title: A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate.

PubMed ID: 10873380

DOI: 10.1006/geno.2000.6214

PubMed ID: 11568975

Title: Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors.

PubMed ID: 11568975

DOI: 10.1002/mc.1063

PubMed ID: 12670906

Title: PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer.

PubMed ID: 12670906

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12907594

Title: PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.

PubMed ID: 12907594

PubMed ID: 18703514

Title: A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells.

PubMed ID: 18703514

DOI: 10.1074/jbc.m710528200

PubMed ID: 20129061

Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.

PubMed ID: 20129061

DOI: 10.1016/j.molcel.2009.10.028

PubMed ID: 24627487

Title: C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.

PubMed ID: 24627487

DOI: 10.1074/jbc.m114.558981

Sequence Information:

Length: 287
Mass: 31609
Checksum: 6103473561AE08DA
Sequence:

MHRLMGVNST AAAAAGQPNV SCTCNCKRSL FQSMEITELE FVQIIIIVVV MMVMVVVITC 
LLSHYKLSAR SFISRHSQGR RREDALSSEG CLWPSESTVS GNGIPEPQVY APPRPTDRLA 
VPPFAQRERF HRFQPTYPYL QHEIDLPPTI SLSDGEEPPP YQGPCTLQLR DPEQQLELNR 
ESVRAPPNRT IFDSDLMDSA RLGGPCPPSS NSGISATCYG SGGRMEGPPP TYSEVIGHYP 
GSSFQHQQSS GPPSLLEGTR LHHTHIAPLE SAAIWSKEKD KQKGHPL

Genular Protein ID: 1181878468

Symbol: Q5JY37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JY37

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 252
Mass: 27900
Checksum: 0864B9DAB8A21959
Sequence:

MAELEFVQII IIVVVMMVMV VVITCLLSHY KLSARSFISR HSQGRRREDA LSSEGCLWPS 
ESTVSGNGIP EPQVYAPPRP TDRLAVPPFA QRERFHRFQP TYPYLQHEID LPPTISLSDG 
EEPPPYQGPC TLQLRDPEQQ LELNRESVRA PPNRTIFDSD LMDSARLGGP CPPSSNSGIS 
ATCYGSGGRM EGPPPTYSEV IGHYPGSSFQ HQQSSGPPSL LEGTRLHHTH IAPLESAAIW 
SKEKDKQKGH PL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PMEPA1

Associated with

Other Information

A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. PubMed ID: 10873380

Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. PubMed ID: 11568975

PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. PubMed ID: 12670906

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. PubMed ID: 12907594

A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. PubMed ID: 18703514

TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. PubMed ID: 20129061

C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling. PubMed ID: 24627487

The sequence of the human genome. PubMed ID: 11181995