Details for: DUSP22

Gene ID: 56940

Symbol: DUSP22

Ensembl ID: ENSG00000112679

Description: dual specificity phosphatase 22

Associated with

  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dephosphorylation
    (GO:0016311)
  • Filamentous actin
    (GO:0031941)
  • Leading edge of lamellipodium
    (GO:0061851)
  • Myosin phosphatase activity
    (GO:0017018)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of focal adhesion assembly
    (GO:0051895)
  • Negative regulation of non-membrane spanning protein tyrosine kinase activity
    (GO:1903996)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of t cell mediated immunity
    (GO:0002710)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Non-membrane spanning protein tyrosine phosphatase activity
    (GO:0004726)
  • Peptidyl-tyrosine dephosphorylation
    (GO:0035335)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Protein tyrosine/serine/threonine phosphatase activity
    (GO:0008138)
  • Protein tyrosine kinase binding
    (GO:1990782)
  • Protein tyrosine phosphatase activity
    (GO:0004725)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Signal transduction
    (GO:0007165)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)

Other Information

Genular Protein ID: 3943974867

Symbol: DUS22_HUMAN

Name: Dual specificity protein phosphatase 22

UniProtKB Accession Codes:

Q9NRW4 B4DK56 Q59GW2 Q5VWR2 Q96AR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 9 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11717427

Title: Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.

PubMed ID: 11717427

DOI: 10.1073/pnas.231499098

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20553486

Title: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis.

PubMed ID: 20553486

DOI: 10.1111/j.1742-4658.2010.07661.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17068812

Title: Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution.

PubMed ID: 17068812

DOI: 10.1002/prot.21152

Sequence Information:

  • Length: 184
  • Mass: 20910
  • Checksum: B3F962A087C2BA20
  • Sequence:
    • MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY LCIPAADSPS 
QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI AYIMTVTDFG WEDALHTVRA 
GRSCANPNVG FQRQLQEFEK HEVHQYRQWL KEEYGESPLQ DAEEAKNILA APGILKFWAF 
LRRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.