Details for: HMCES

Gene ID: 56941

Symbol: HMCES

Ensembl ID: ENSG00000183624

Description: 5-hydroxymethylcytosine binding, ES cell specific

Associated with

Other Information

Genular Protein ID: 4210053923

Symbol: HMCES_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96FZ2 A6NJR9 Q96G34 Q9NRP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23945014

Title: Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems.

PubMed ID: 23945014

DOI: 10.1186/1745-6150-8-20

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30554877

Title: HMCES maintains genome integrity by shielding abasic sites in single-strand DNA.

PubMed ID: 30554877

DOI: 10.1016/j.cell.2018.10.055

PubMed ID: 31235915

Title: Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.

PubMed ID: 31235915

DOI: 10.1038/s41594-019-0255-5

PubMed ID: 31235913

Title: Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.

PubMed ID: 31235913

DOI: 10.1038/s41594-019-0246-6

PubMed ID: 31806351

Title: HMCES functions in the alternative end-joining pathway of the DNA DSB repair during class switch recombination in B cells.

PubMed ID: 31806351

DOI: 10.1016/j.molcel.2019.10.031

Sequence Information:

  • Length: 354
  • Mass: 40575
  • Checksum: 209496BB7E331785
  • Sequence:
    • MCGRTSCHLP RDVLTRACAY QDRRGQQRLP EWRDPDKYCP SYNKSPQSNS PVLLSRLHFE 
KDADSSERII APMRWGLVPS WFKESDPSKL QFNTTNCRSD TVMEKRSFKV PLGKGRRCVV 
LADGFYEWQR CQGTNQRQPY FIYFPQIKTE KSGSIGAADS PENWEKVWDN WRLLTMAGIF 
DCWEPPEGGD VLYSYTIITV DSCKGLSDIH HRMPAILDGE EAVSKWLDFG EVSTQEALKL 
IHPTENITFH AVSSVVNNSR NNTPECLAPV DLVVKKELRA SGSSQRMLQW LATKSPKKED 
SKTPQKEESD VPQWSSQFLQ KSPLPTKRGT AGLLEQWLKR EKEEEPVAKR PYSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.