SMYD2 | ENSG00000143499 | NCBI 56950

Details for: SMYD2

Gene ID: 56950

Symbol: SMYD2

Ensembl ID: ENSG00000143499

Description: SET and MYND domain containing 2

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Pkmts methylate histone lysines
(R-HSA-3214841)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through methylation
(R-HSA-6804760)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by tp53
(R-HSA-3700989)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Heart development
(GO:0007507)
Histone h3 methyltransferase activity
(GO:0140938)
Histone h3k4 trimethyltransferase activity
(GO:0140999)
Histone h3k36 methyltransferase activity
(GO:0046975)
Lysine n-methyltransferase activity
(GO:0016278)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Peptidyl-lysine dimethylation
(GO:0018027)
Peptidyl-lysine monomethylation
(GO:0018026)
Protein-lysine n-methyltransferase activity
(GO:0016279)
Protein binding
(GO:0005515)
Regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043516)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Rna polymerase ii complex binding
(GO:0000993)

Other Information

Proteins

N-lysine methyltransferase SMYD2

Genular Protein ID: 1342294386

Symbol: SMYD2_HUMAN

Name: N-lysine methyltransferase SMYD2

UniProtKB Accession Codes:

Q9NRG4 B2R9P9 I6L9H7 Q4V765 Q5VSH9 Q96AI4

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17108971

Title: Repression of p53 activity by Smyd2-mediated methylation.

PubMed ID: 17108971

DOI: 10.1038/nature05287

PubMed ID: 17242690

Title: C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.

PubMed ID: 17242690

DOI: 10.1038/sj.cr.7310121

PubMed ID: 17805299

Title: p53 is regulated by the lysine demethylase LSD1.

PubMed ID: 17805299

DOI: 10.1038/nature06092

PubMed ID: 18065756

Title: The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase.

PubMed ID: 18065756

DOI: 10.1074/mcp.m700271-mcp200

PubMed ID: 20870719

Title: Methylation of the retinoblastoma tumor suppressor by SMYD2.

PubMed ID: 20870719

DOI: 10.1074/jbc.m110.137612

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21724641

Title: Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins.

PubMed ID: 21724641

DOI: 10.1093/jmcb/mjr015

PubMed ID: 21880715

Title: Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.

PubMed ID: 21880715

DOI: 10.1074/jbc.m111.262410

PubMed ID: 21782458

Title: Structural basis of substrate methylation and inhibition of SMYD2.

PubMed ID: 21782458

DOI: 10.1016/j.str.2011.06.011

Sequence Information:

Length: 433
Mass: 49688
Checksum: 3EEA5B8417870F5D
Sequence:

MRAEGLGGLE RFCSPGKGRG LRALQPFQVG DLLFSCPAYA YVLTVNERGN HCEYCFTRKE 
GLSKCGRCKQ AFYCNVECQK EDWPMHKLEC SPMVVFGENW NPSETVRLTA RILAKQKIHP 
ERTPSEKLLA VKEFESHLDK LDNEKKDLIQ SDIAALHHFY SKHLGFPDND SLVVLFAQVN 
CNGFTIEDEE LSHLGSAIFP DVALMNHSCC PNVIVTYKGT LAEVRAVQEI KPGEEVFTSY 
IDLLYPTEDR NDRLRDSYFF TCECQECTTK DKDKAKVEIR KLSDPPKAEA IRDMVRYARN 
VIEEFRRAKH YKSPSELLEI CELSQEKMSS VFEDSNVYML HMMYQAMGVC LYMQDWEGAL 
QYGQKIIKPY SKHYPLYSLN VASMWLKLGR LYMGLEHKAA GEKALKKAIA IMEVAHGKDH 
PYISEIKQEI ESH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SMYD2

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Repression of p53 activity by Smyd2-mediated methylation. PubMed ID: 17108971

C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42. PubMed ID: 17242690

p53 is regulated by the lysine demethylase LSD1. PubMed ID: 17805299

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. PubMed ID: 18065756

Methylation of the retinoblastoma tumor suppressor by SMYD2. PubMed ID: 20870719

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins. PubMed ID: 21724641

Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. PubMed ID: 21880715

Structural basis of substrate methylation and inhibition of SMYD2. PubMed ID: 21782458