MEPE | ENSG00000152595 | NCBI 56955

Details for: MEPE

Gene ID: 56955

Symbol: MEPE

Ensembl ID: ENSG00000152595

Description: matrix extracellular phosphoglycoprotein

Associated with

Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Biomineral tissue development
(GO:0031214)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular matrix
(GO:0031012)
Extracellular matrix protein binding
(GO:1990430)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Protein binding
(GO:0005515)
Skeletal system development
(GO:0001501)

Other Information

Proteins

MEPE_HUMAN
Q8NC19_HUMAN

Genular Protein ID: 1801354843

Symbol: MEPE_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NQ76 A1A4X9 A8MTA3 D2CFR4 F5H5C5

Database IDs:

Citations:

PubMed ID: 10945470

Title: MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.

PubMed ID: 10945470

DOI: 10.1006/geno.2000.6235

PubMed ID: 11414762

Title: Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone.

PubMed ID: 11414762

DOI: 10.1006/geno.2001.6553

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12220505

Title: Inhibition of MEPE cleavage by Phex.

PubMed ID: 12220505

DOI: 10.1016/s0006-291x(02)02125-3

PubMed ID: 12489176

Title: MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.

PubMed ID: 12489176

DOI: 10.1080/03008200290000556

PubMed ID: 14962809

Title: MEPE has the properties of an osteoblastic phosphatonin and minhibin.

PubMed ID: 14962809

DOI: 10.1016/j.bone.2003.10.005

PubMed ID: 15108058

Title: Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone.

PubMed ID: 15108058

DOI: 10.1007/s00774-003-0468-9

PubMed ID: 15040834

Title: A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo.

PubMed ID: 15040834

DOI: 10.1359/jbmr.0301263

PubMed ID: 15153459

Title: Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation.

PubMed ID: 15153459

DOI: 10.1177/154405910408300612

PubMed ID: 15329369

Title: Expression of SIBLINGs and their partner MMPs in salivary glands.

PubMed ID: 15329369

DOI: 10.1177/154405910408300902

PubMed ID: 15664000

Title: Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).

PubMed ID: 15664000

DOI: 10.1016/j.bone.2004.09.015

PubMed ID: 18162525

Title: Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP.

PubMed ID: 18162525

DOI: 10.1210/en.2007-1205

PubMed ID: 18597632

Title: MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM.

PubMed ID: 18597632

DOI: 10.1359/jbmr.080601

PubMed ID: 18547474

Title: Changes in matrix extracellular phosphoglycoprotein expression before and during in vitro osteogenic differentiation of human dental papilla mesenchymal cells.

PubMed ID: 18547474

DOI: 10.1177/039463200802100207

PubMed ID: 19005008

Title: Matrix extracellular phosphoglycoprotein inhibits phosphate transport.

PubMed ID: 19005008

DOI: 10.1681/asn.2008030315

PubMed ID: 19998030

Title: MEPE's diverse effects on mineralization.

PubMed ID: 19998030

DOI: 10.1007/s00223-009-9313-z

PubMed ID: 20581062

Title: Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.

PubMed ID: 20581062

DOI: 10.2353/ajpath.2010.091231

PubMed ID: 22766095

Title: MEPE is a novel regulator of growth plate cartilage mineralization.

PubMed ID: 22766095

DOI: 10.1016/j.bone.2012.06.022

PubMed ID: 22341070

Title: The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells.

PubMed ID: 22341070

DOI: 10.1016/j.joen.2011.10.015

PubMed ID: 22582013

Title: Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

PubMed ID: 22582013

DOI: 10.1126/science.1217817

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

Length: 525
Mass: 58419
Checksum: 0977CA6E871CA9E5
Sequence:

MRVFCVGLLL FSVTWAAPTF QPQTEKTKQS CVEEQRQEEK NKDNIGFHHL GKRINQELSS 
KENIVQERKK DLSLSEASEN KGSSKSQNYF TNRQRLNKEY SISNKENTHN GLRMSIYPKS 
TGNKGFEDGD DAISKLHDQE EYGAALIRNN MQHIMGPVTA IKLLGEENKE NTPRNVLNII 
PASMNYAKAH SKDKKKPQRD SQAQKSPVKS KSTHRIQHNI DYLKHLSKVK KIPSDFEGSG 
YTDLQERGDN DISPFSGDGQ PFKDIPGKGE ATGPDLEGKD IQTGFAGPSE AESTHLDTKK 
PGYNEIPERE ENGGNTIGTR DETAKEADAV DVSLVEGSND IMGSTNFKEL PGREGNRVDA 
GSQNAHQGKV EFHYPPAPSK EKRKEGSSDA AESTNYNEIP KNGKGSTRKG VDHSNRNQAT 
LNEKQRFPSK GKSQGLPIPS RGLDNEIKNE MDSFNGPSHE NIITHGRKYH YVPHRQNNST 
RNKGMPQGKG SWGRQPHSNR RFSSRRRDDS SESSDSGSSS ESDGD

Genular Protein ID: 950629370

Symbol: Q8NC19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NC19

Database IDs:

Sequence Information:

Length: 275
Mass: 31358
Checksum: AF0B426A671B665C
Sequence:

MRVFCVGLLL FSVTWAAPTF QPQTEKTKQS CVEEQRQEEK NKDNIGFHHL GKRINQELSS 
KENIVQERKK DLSLSEASEN KGSSKSQNYF TNRQRLNKEY SISNKENTHN GLRMSIYPKS 
TGNKGFEDGD DAISKLHDQE EYGAALIRNN MQHIMGPVTA IKLLGEENKE NTPRNVLNII 
PASMNYAKAH SKDKKKPQRD SQAQKSPVKS KSTHRIQHNI DYLKHLSKVK KIPSDFEGSG 
YTDLQERGDN DISPFRGTAN LLRTFLVKEK LLVLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MEPE

Associated with

Other Information

MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. PubMed ID: 10945470

Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. PubMed ID: 11414762

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of MEPE cleavage by Phex. PubMed ID: 12220505

MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. PubMed ID: 12489176

MEPE has the properties of an osteoblastic phosphatonin and minhibin. PubMed ID: 14962809

Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. PubMed ID: 15108058

A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo. PubMed ID: 15040834

Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation. PubMed ID: 15153459

Expression of SIBLINGs and their partner MMPs in salivary glands. PubMed ID: 15329369

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). PubMed ID: 15664000

Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. PubMed ID: 18162525

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. PubMed ID: 18597632

Changes in matrix extracellular phosphoglycoprotein expression before and during in vitro osteogenic differentiation of human dental papilla mesenchymal cells. PubMed ID: 18547474

Matrix extracellular phosphoglycoprotein inhibits phosphate transport. PubMed ID: 19005008

MEPE's diverse effects on mineralization. PubMed ID: 19998030

Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin. PubMed ID: 20581062

MEPE is a novel regulator of growth plate cartilage mineralization. PubMed ID: 22766095

The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells. PubMed ID: 22341070

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. PubMed ID: 22582013

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics. PubMed ID: 37453717