OTUD7B | ENSG00000264522 | NCBI 56957

Details for: OTUD7B

Gene ID: 56957

Symbol: OTUD7B

Ensembl ID: ENSG00000264522

Description: OTU deubiquitinase 7B

Associated with

Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Metabolism of proteins
(R-HSA-392499)
Ovarian tumor domain proteases
(R-HSA-5689896)
Post-translational protein modification
(R-HSA-597592)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Signal transduction
(R-HSA-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnf signaling
(R-HSA-75893)
Adaptive immune response
(GO:0002250)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
In utero embryonic development
(GO:0001701)
K48-linked deubiquitinase activity
(GO:1990380)
K63-linked polyubiquitin modification-dependent protein binding
(GO:0070530)
Mucosal immune response
(GO:0002385)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of protein localization to nucleus
(GO:1900181)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein deubiquitination involved in ubiquitin-dependent protein catabolic process
(GO:0071947)
Protein k11-linked deubiquitination
(GO:0035871)
Protein k48-linked deubiquitination
(GO:0071108)
Protein k63-linked deubiquitination
(GO:0070536)
Proteolysis
(GO:0006508)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

OTU domain-containing protein 7B

Genular Protein ID: 1537622455

Symbol: OTU7B_HUMAN

Name: OTU domain-containing protein 7B

UniProtKB Accession Codes:

Q6GQQ9 B7Z643 D3DUZ8 Q5SZ60 Q8WWA7 Q9NQ53 Q9UFF4

Database IDs:

Citations:

PubMed ID: 11463333

Title: Isolation and characterization of two novel A20-like proteins.

PubMed ID: 11463333

DOI: 10.1042/0264-6021:3570617

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12682062

Title: A novel type of deubiquitinating enzyme.

PubMed ID: 12682062

DOI: 10.1074/jbc.m301863200

PubMed ID: 14748687

Title: Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

PubMed ID: 14748687

DOI: 10.1042/bj20031377

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18178551

Title: NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.

PubMed ID: 18178551

DOI: 10.1074/jbc.m708690200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20622874

Title: Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

PubMed ID: 20622874

DOI: 10.1038/nsmb.1873

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21097510

Title: DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B.

PubMed ID: 21097510

DOI: 10.1074/jbc.m110.147371

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21888622

Title: A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.

PubMed ID: 21888622

DOI: 10.1042/bj20111300

PubMed ID: 22179831

Title: Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.

PubMed ID: 22179831

DOI: 10.1038/onc.2011.587

PubMed ID: 23827681

Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PubMed ID: 23827681

DOI: 10.1016/j.cell.2013.05.046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26903241

Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.

PubMed ID: 26903241

DOI: 10.1084/jem.20151426

PubMed ID: 27732584

Title: Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

PubMed ID: 27732584

DOI: 10.1038/nature19836

Sequence Information:

Length: 843
Mass: 92526
Checksum: 6D386C864B12EE57
Sequence:

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVNAALSD FEQLRQVHAG NLPPSFSEGS 
GGSRTPEKGF SDREPTRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 
GGSNEHPLEM PICAFQLPDL TVYNEDFRSF IERDLIEQSM LVALEQAGRL NWWVSVDPTS 
QRLLPLATTG DGNCLLHAAS LGMWGFHDRD LMLRKALYAL MEKGVEKEAL KRRWRWQQTQ 
QNKESGLVYT EDEWQKEWNE LIKLASSEPR MHLGTNGANC GGVESSEEPV YESLEEFHVF 
VLAHVLRRPI VVVADTMLRD SGGEAFAPIP FGGIYLPLEV PASQCHRSPL VLAYDQAHFS 
ALVSMEQKEN TKEQAVIPLT DSEYKLLPLH FAVDPGKGWE WGKDDSDNVR LASVILSLEV 
KLHLLHSYMN VKWIPLSSDA QAPLAQPESP TASAGDEPRS TPESGDSDKE SVGSSSTSNE 
GGRRKEKSKR DREKDKKRAD SVANKLGSFG KTLGSKLKKN MGGLMHSKGS KPGGVGTGLG 
GSSGTETLEK KKKNSLKSWK GGKEEAAGDG PVSEKPPAES VGNGGSKYSQ EVMQSLSILR 
TAMQGEGKFI FVGTLKMGHR HQYQEEMIQR YLSDAEERFL AEQKQKEAER KIMNGGIGGG 
PPPAKKPEPD AREEQPTGPP AESRAMAFST GYPGDFTIPR PSGGGVHCQE PRRQLAGGPC 
VGGLPPYATF PRQCPPGRPY PHQDSIPSLE PGSHSKDGLH RGALLPPPYR VADSYSNGYR 
EPPEPDGWAG GLRGLPPTQT KCKQPNCSFY GHPETNNFCS CCYREELRRR EREPDGELLV 
HRF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OTUD7B

Associated with

Other Information

Isolation and characterization of two novel A20-like proteins. PubMed ID: 11463333

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

A novel type of deubiquitinating enzyme. PubMed ID: 12682062

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. PubMed ID: 14748687

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. PubMed ID: 18178551

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. PubMed ID: 20622874

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. PubMed ID: 21097510

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. PubMed ID: 21888622

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. PubMed ID: 22179831

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. PubMed ID: 23827681

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. PubMed ID: 26903241

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. PubMed ID: 27732584