FAM20C | ENSG00000177706 | NCBI 56975

Details for: FAM20C

Gene ID: 56975

Symbol: FAM20C

Ensembl ID: ENSG00000177706

Description: FAM20C golgi associated secretory pathway kinase

Associated with

Metabolism of proteins
(R-HSA-392499)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Atp binding
(GO:0005524)
Biomineral tissue development
(GO:0031214)
Calcium ion binding
(GO:0005509)
Dentinogenesis
(GO:0097187)
Enamel mineralization
(GO:0070166)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Manganese ion binding
(GO:0030145)
Nucleoplasm
(GO:0005654)
Odontoblast differentiation
(GO:0071895)
Osteoclast maturation
(GO:0036179)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of osteoblast differentiation
(GO:0045669)
Post-translational protein modification
(GO:0043687)
Protease binding
(GO:0002020)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein metabolic process
(GO:0019538)
Protein phosphorylation
(GO:0006468)
Protein self-association
(GO:0043621)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of fibroblast growth factor receptor signaling pathway
(GO:0040036)
Regulation of phosphorus metabolic process
(GO:0051174)

Other Information

Proteins

FA20C_HUMAN

Genular Protein ID: 4103685242

Symbol: FA20C_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IXL6 A4D2Q5 L8B5W8 Q5I0W9 Q7Z4I0 Q9NPT2

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 34349020

Title: Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.

PubMed ID: 34349020

DOI: 10.1073/pnas.2100133118

PubMed ID: 15676076

Title: FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells.

PubMed ID: 15676076

DOI: 10.1186/1471-2164-6-11

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22582013

Title: Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

PubMed ID: 22582013

DOI: 10.1126/science.1217817

PubMed ID: 23754375

Title: Crystal structure of the Golgi casein kinase.

PubMed ID: 23754375

DOI: 10.1073/pnas.1309211110

PubMed ID: 25789606

Title: A secretory kinase complex regulates extracellular protein phosphorylation.

PubMed ID: 25789606

DOI: 10.7554/elife.06120

PubMed ID: 29858230

Title: Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha.

PubMed ID: 29858230

DOI: 10.15252/embj.201798699

PubMed ID: 32149426

Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PubMed ID: 32149426

DOI: 10.15252/embj.2019103841

PubMed ID: 17924334

Title: Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development.

PubMed ID: 17924334

DOI: 10.1086/522240

Sequence Information:

Length: 584
Mass: 66234
Checksum: ECD278B5EA681FEF
Sequence:

MKMMLVRRFR VLILMVFLVA CALHIALDLL PRLERRGARP SGEPGCSCAQ PAAEVAAPGW 
AQVRGRPGEP PAASSAAGDA GWPNKHTLRI LQDFSSDPSS NLSSHSLEKL PPAAEPAERA 
LRGRDPGALR PHDPAHRPLL RDPGPRRSES PPGPGGDASL LARLFEHPLY RVAVPPLTEE 
DVLFNVNSDT RLSPKAAENP DWPHAGAEGA EFLSPGEAAV DSYPNWLKFH IGINRYELYS 
RHNPAIEALL HDLSSQRITS VAMKSGGTQL KLIMTFQNYG QALFKPMKQT REQETPPDFF 
YFSDYERHNA EIAAFHLDRI LDFRRVPPVA GRMVNMTKEI RDVTRDKKLW RTFFISPANN 
ICFYGECSYY CSTEHALCGK PDQIEGSLAA FLPDLSLAKR KTWRNPWRRS YHKRKKAEWE 
VDPDYCEEVK QTPPYDSSHR ILDVMDMTIF DFLMGNMDRH HYETFEKFGN ETFIIHLDNG 
RGFGKYSHDE LSILVPLQQC CRIRKSTYLR LQLLAKEEYK LSLLMAESLR GDQVAPVLYQ 
PHLEALDRRL RVVLKAVRDC VERNGLHSVV DDDLDTEHRA ASAR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FAM20C

Associated with

Other Information

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization. PubMed ID: 34349020

FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. PubMed ID: 15676076

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. PubMed ID: 22582013

Crystal structure of the Golgi casein kinase. PubMed ID: 23754375

A secretory kinase complex regulates extracellular protein phosphorylation. PubMed ID: 25789606

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha. PubMed ID: 29858230

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. PubMed ID: 32149426

Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. PubMed ID: 17924334